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Stroke. 2009;40:S24-S27
Published online before print December 8, 2008, doi: 10.1161/STROKEAHA.108.526814
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(Stroke. 2009;40:S24.)
© 2009 American Heart Association, Inc.

Imaging and Biomarkers

MR and CT Monitoring of Recanalization, Reperfusion, and Penumbra Salvage

Everything That Recanalizes Does Not Necessarily Reperfuse!

Bruno P. Soares, MD; Jeffrey D. Chien, BA Max Wintermark, MD

From the Department of Radiology, Neuroradiology Section, University of California, San Francisco.

Correspondence to Max Wintermark, MD, University of California, San Francisco, Department of Radiology, Neuroradiology Section, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143-0628. E-mail Max.Wintermark{at}radiology.ucsf.edu

Revascularization therapies for acute stroke patients aim to rescue the ischemic penumbra by restoring the patency of the occluded artery ("recanalization") and the downstream capillary blood flow ("reperfusion"). This article reviews the definition of recanalization and reperfusion used in stroke clinical trials and their limitations and proposes a study design to determine the relative importance of recanalization, reperfusion, and collateral flow in evaluating the efficacy of revascularization therapies for acute ischemic stroke.


Key Words: brain infarction • brain ischemia • cerebral infarct • CT • magnetic resonance • neuroradiology • reprefusion • tPA




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J. L. Saver, G. W. Albers, B. Dunn, K. C. Johnston, M. Fisher, and for the STAIR VI Consortium
Stroke Therapy Academic Industry Roundtable (STAIR) Recommendations for Extended Window Acute Stroke Therapy Trials
Stroke, July 1, 2009; 40(7): 2594 - 2600.
[Abstract] [Full Text] [PDF]


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