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(Stroke. 2009;40:S28.)
© 2009 American Heart Association, Inc.

Imaging and Biomarkers

Use of Imaging in Restorative Stroke Trials

From the Departments of Neurology and Anatomy & Neurobiology, University of California, Irvine.

Correspondence to Steven C. Cramer, MD, University of California, Irvine Medical Center, 101 The City Drive South, Building 53 Room 203, Orange, CA 92868-4280. E-mail scramer{at}uci.edu

Restorative therapies aim to improve behavioral outcome after stroke by promoting repair and restoration. Measures of CNS injury and function might be useful to evaluate such therapies in a clinical trial, for example, by optimizing patient selection or treatment dose. These issues are considered in this review, with specific examples provided.

Key Words: stroke • plasticity • recovery • brain mapping