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(Stroke. 2009;40:S61.)
© 2009 American Heart Association, Inc.

Prevention 1: Genetics

Whole Genome Approaches in Ischemic Stroke

From the Department of Neurology, Mayo Clinic, Jacksonville, Fla.

Correspondence to James F. Meschia, MD, Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224. E-mail meschia.james{at}mayo.edu

Background and Purpose— The field of ischemic stroke genetics is moving beyond candidate gene studies into the realm of genomewide association studies. Such studies have resulted in discoveries in diverse, complex disorders.

Methods— The author conducted an informal qualitative review of peer-reviewed medical literature.

Results— The power of genomewide association studies to confirm prior associations and establish new ones is illustrated by recent work focusing on type 2 diabetes mellitus. A pilot genomewide association study of ischemic stroke failed to identify a single gene of major effect.

Conclusions— Follow-up studies with substantially greater statistical power are essential and are being planned by the Wellcome Trust and others.

Key Words: ischemia • whole genome • consesus data elements