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(Stroke. 2009;40:2973.)
© 2009 American Heart Association, Inc.

Original Contributions

The 1425G/A SNP in PRKCH Is Associated With Ischemic Stroke and Cerebral Hemorrhage in a Chinese Population

Lijun Wu, PhD; Yue Shen, MS; Xin Liu, PhD; Xu Ma, MD, PhD; Bo Xi, MS; Jie Mi, MD; Klaus Lindpaintner, MD; Xuerui Tan, MD, PhD Xingyu Wang, PhD

From the First Affiliated Hospital (L.W., X.L., X.T.), Medical College of Shantou University, Shantou, China; the Laboratory of Human Genetics (Y.S., X.L., X.W.), Beijing Hypertension League Institute, Beijing, China; the National Research Institute for Family Planning (X.M.), Beijing, China; the Department of Epidemiology (B.X., J.M.), Capital Institute of Pediatrics, Beijing, China; and the Roche Center for Medical Genomics (K.L.), F. Hoffmann-La Roche Ltd, Basel, Switzerland.

Correspondence to Xingyu Wang, PhD, Laboratory of Human Genetics, Beijing Hypertension League Institute, 24 Shijingshan Road, Beijing, China, 100043. E-mail xingyuw{at}yahoo.com; or to Xuerui Tan, MD, PhD, the First Affiliated Hospital, Medical College of Shantou University, No. 57, Changping Road, Shantou, Guangdong, China 515041. E-mail tanxuerui@vip.sina.com

Background and Purpose— PRKCH (the gene encoding protein kinase C ) has a role in the pathogenesis of ischemic stroke. The 1425G/A SNP in PRKCH (rs2230500) is significantly associated with ischemic stroke in Japanese. The aim of the present study is to investigate the associations in ischemic stroke and other types of stroke in the Chinese population.

Methods— A total of 1209 patients with stroke and 1174 controls were examined using a case–control methodology. The 1425G/A SNP in PRKCH was genotyped by allele-specific real-time PCR assay.

Results— The 1425G/A SNP in PRKCH was significantly associated with both ischemic stroke (odds ratio [OR]=1.31; 95% confidence interval [CI], 1.08 to 1.60; P=0.0058) and cerebral hemorrhage (OR=1.94; 95% CI, 1.21 to 3.10; P=0.0054) under a dominant model. Even after age- and sex-adjustment, the significant associations remained (in ischemic stroke, for AA+AG versus GG, OR=1.37, 95% CI, 1.12 to 1.67, P=0.0019; in cerebral hemorrhage, for AA+AG versus GG, OR=1.96, 95% CI, 1.21 to 3.19, P=0.0064).

Conclusions— The 1425G/A SNP in PRKCH increases the risk of both ischemic stroke and cerebral hemorrhage in the Chinese population.

Key Words: ischemic stroke • cerebral hemorrhage • PRKCH