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(Stroke. 1974;5:155.)
© 1974 American Heart Association, Inc.

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The Effects of lodinated Contrast Agents on Autoregulation of Cerebral Blood Flow

ROBERT L. GRUBB JR. M.D.¹; MILTON J. HERNANDEZ-PERIZ PH.D.²; MARCUS E. RAICHLE M.D.³; MICHAEL E. PHELPS PH.D.⁴

¹ Division of Neurosurgery, Washington University School of Medicine, St. Louis, Missouri 63110
² Division of Neurology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033
³ Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110
⁴ Division of Radiation Sciences, The Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110

The effects of an iodinated contrast agent, Renografin-76® upon cerebral autoregulation was studied in rhesus monkeys. This was done by measuring the effects of an intravenous injection of Renografin-76 upon: (1) the response of baseline CBF as measured by the washout of a carotid bolus of H₂¹⁵O during and after the injection of Renografin-76, (2) the response of CBF monitored continuously by a Doppler flow probe technique to changes in the mean arterial blood pressure (MABP) before and after an injection of Renografin-76, and (3) the response of the regional cerebral blood volume (rCBV) as measured by stimulated x-ray fluorescence. An intravenous injection of Renografin-76 can disturb cerebral autoregulation in the rhesus monkey for as long as 15 minutes after the beginning of the injection. After the intravenous in jection of Renografin-76, transient rises in both CBF and MABP lasting from 2 to 12 minutes occurred on an average of 23% and 16%, respectively, over control values.

Key Words: cerebral blood volume • cerebral autoregulation • x-ray fluorescence • Doppler flow probe

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