This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by JACKSON, R. T. Articles by POLLOCK, R. A. Search for Related Content PubMed PubMed Citation Articles by JACKSON, R. T. Articles by POLLOCK, R. A.

(Stroke. 1974;5:344.)
© 1974 American Heart Association, Inc.

---

The Effect of Carbon Dioxide Inhalation on Cerebral Blood Flow: A Two-Hour Duration Study in Dogs With Microspheres

RICHARD T. JACKSON PH.D.¹; ALBERT A. CLAIRMONT M.D.¹; RICHARD A. POLLOCK M.D.¹

¹ Division of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322

Dogs breathed one of four gas mixtures (5% CO₂-95% O₂, 5% CO₂-95% air, 10% CO₂-90% O₂, and 10% CO₂-90% air) for as long as two hours. Regional cerebral blood flow as well as flow in nasal, otic, pituitary and skin tissue were measured by means of 15 ± 5 µ radioactively labeled microspheres. The normal values for cerebral blood flow and arterial blood gases were very similar to those of other investigators. Inhalation of CO₂ induced an increase in cerebral blood flow that was significantly higher than is usually reported. Increases varied from 100% (with 5% CO₂-95% air) to 250% (with 10% CO₂-90% O₂). Blood flow in the temporal bone behaved much like that of brain in response to CO₂. In most instances, the pituitary gland blood flow did not increase with inhalation of CO₂.

Key Words: circulation • vasodilation hypercapnia • radioactive tracer • pituitary circulation