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(Stroke. 1974;5:550.)
© 1974 American Heart Association, Inc.

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Cooperative Study of Intracranial Aneurysms and Subarachnoid Hemorrhage. Report on a Randomized Treatment Study

I. Introduction

ADOLPH L. SAHS M.D.¹

¹ Department of Neurology, University Hospitals, Iowa City, Iowa 52242

Reprint requests should be forwarded to: Aneurysm Registry, Department of Neurology, University of Iowa, Iowa City, Iowa 52242

Fifteen institutions participated in a cooperative study for treatment of single ruptured intracranial aneurysms. Between June, 1963, and February, 1970, 1,005 protocols were submitted to the Central Registry. All patients had a single ruptured aneurysm on the internal carotid, middle cerebral, anterior cerebral-anterior communicating or vertebral-basilar arteries. The four treatments allocated randomly were regulated bed rest, drug-induced hypotension, carotid ligation, and intracranial surgery. This study was an attempt to provide the relative merits of these several modes of therapy.

Key Words: randomized study • cooperative aneurysm study • treatment of intracranial aneurysms