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(Stroke. 1974;5:557.)
© 1974 American Heart Association, Inc.

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COOPERATIVE STUDY OF INTRACRANIAL ANEURYSMS AND SUBARACHNOID HEMORRHAGE Report on a Randomized Treatment Study

III. Intracranial Surgery

CARL J. GRAF M.D.¹ DONALD W. NIBBELINK M.D.²

¹ Department of Neurosurgery, University Hospitals, Iowa City, Iowa 52242
² Department of Neurology, University Hospitals, Iowa City, Iowa 52242

Reprint requests: Aneurysm Registry, Department of Neurology. Iowa City, Iowa 52242.

A group of 274 patients with a single intracranial aneurysm was randomly allocated to intracranial surgery. Forty patients had no surgical procedure. Only six had a vertebral-basilar aneurysm. The remaining 228 patients had an aneurysm on the anterior portion of the circle of Willis. Mortality during the six and one-half-year interval was 36.8%. When the operation was performed within 14 days following the last bleed, mortality was 44.5%; for those operated upon after the 14-day interval mortality was 23.2%. Postoperative complications occurred in 47.8%.

Key Words: cooperative aneurysm study • intracranial aneurysm • intracranial aneurysm surgery • ruptured intracranial aneurysm

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