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(Stroke. 1975;6:149.)
© 1975 American Heart Association, Inc.

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Estimating Total Cerebral Blood Flow From the Initial Slope of Hydrogen Washout Curves

T. F. DOYLE B.S.¹; A. N. MARTINS M.D.¹; A. I. KOBRINE M.D.¹

¹ Neurobiology Division, Armed Forces Radiobiology Research Institute, Defense Nuclear Agency, Bethesda, Maryland 20014; Neurosurgery Service, Walter Reed General Hospital, Washington, D.C. 20012

An initial slope index of total cerebral blood flow, measured by the hydrogen clearance technique, shows a high correlation with flows calculated by bicompartmental analysis. In 247 flow measurements done on 41 rhesus monkeys, a linear regression analysis between these two methods of calculating flow shows a correlation coefficient of 0.928 with a standard error about y values of ± 7.63. The initial slope index is not only faster but does not require that a steady state be maintained for ten minutes.

Key Words: bicompartmental analysis • hydrogen washout technique • normocapnia • hypocapnia • hypercapnia

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