This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by PANNIER, J. L. Articles by LEUSEN, I. Search for Related Content PubMed PubMed Citation Articles by PANNIER, J. L. Articles by LEUSEN, I.

(Stroke. 1975;6:188.)
© 1975 American Heart Association, Inc.

---

Cerebral Blood Flow in Cats After an Acute Hypertensive Insult With Damage to the Blood-Brain Barrier

J. L. PANNIER M.D.¹ I. LEUSEN M.D.¹

¹ Laboratory of Normal and Pathological Physiology, University of Ghent, De Pintelaan 135, B-9000 Ghent, Belgium

Cerebral blood flow was measured with the ¹³³Xenon clearance method in anesthetized cats under controlled ventilation. An acute pressure increase in the carotid system increases the cerebrovascular permeability to Evans blue, indicating damage to the blood-brain barrier. In these conditions the reactivity of cerebral blood vessels toward changes in the acid-base balance is altered: the CO₂ reactivity is less pronounced, while the effect of increasing the plasma [HCO^-₃] is more pronounced than in normal cats. Autoregulatory capacity toward moderate alterations in arterial blood pressure or in intracranial pressure is well maintained in these conditions.

Key Words: hypertension • intracranial pressure • pH • autoregulation