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Stroke. 1975;6:199-205

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(Stroke. 1975;6:199.)
© 1975 American Heart Association, Inc.

Characterization of Malignant Gliomas and Cerebrovascular Disease by Cerebral Dynamic Studies

LYNN R. WITHERSPOON M.D.1; R. S. PREISSIG M.D.2; M. S. MAHALEY JR. M.D.2; J. WENDELL TYSON M.D.3; C. CRAIG HARRIS 2; JOHN R. LEONARD M.D.2; JACK K. GOODRICH M.D.2

1 Department of Nuclear Medicine, Ochsner Foundation Hospital, New Orleans, Louisiana 70121
2 Duke University Medical Center and the Veterans Administration Hospital, Durham, North Carolina
3 Division of Nuclear Medicine, Louisville General Hospital, Louisville, Kentucky 40202

Jack K. Goodrich, Division of Nuclear Medicine, Duke University Medical Center, Durham, North Carolina 27710

A technique for analysis of dynamic radionuclide studies of the cerebral circulation is described. This technique permits objective classification of observed radionuclide distribution patterns. Variation in the time-to-peak activity, and in the maximum attained activity as determined by region-of-interest analysis of cerebral hemispheric activity, was defined for a normal population. Application of these normal values permits classification of observed hemispheric radionuclide distribution patterns in anaplastic gliomas and in occlusive cerebrovascular disease. Radionuclide activity in gliomas may be normal, decreased, or increased in the region of the tumor. In cerebrovascular occlusion, decreased activity, associated with a delay in time-to-peak activity, is frequently demonstrated in the affected hemisphere.


Key Words: brain scanning • anaplastic glioma • hemispheric activity






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