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(Stroke. 1975;6:402.)
© 1975 American Heart Association, Inc.

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A Paradoxical Cerebral Hemodynamic Effect of Hydralazine

JRN OVERGAARD M.D.¹ ERIK SKINHJ M.D.²

¹ Department of Neurosurgery, The University Hospital, Odense, Denmark
² Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark

Hydralazine is shown to have a very complex cerebral hemodynamic effect. It raises the intracranial pressure which, together with its effect upon systemic blood pressure, reduces the cerebral perfusion pressure. In spite of this and a concomitantly induced hyperventilation by hydralazine, CBF increases with some delay. The conclusion is that hydralazine is a cerebral vasodilator acting immediately upon cerebral capacitance vessels but later upon the resistance vessels as well.

Key Words: regional cerebral blood flow • intracranial pressure • cerebral capacitance vessels • cerebral resistance vessels

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