This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by SYMON, L. Articles by CROCKARD, H. A. Search for Related Content PubMed PubMed Citation Articles by SYMON, L. Articles by CROCKARD, H. A.

(Stroke. 1975;6:476.)
© 1975 American Heart Association, Inc.

---

The Production and Clinical Features of a Chronic Stroke Model in Experimental Primates

LINDSAY SYMON F.R.C.S.¹; N. W. C.DORSCH F.R.C.S.¹; H. A. CROCKARD F.R.C.S.¹

¹ Department of Neurosurgical Studies, Institute of Neurology, The National Hospital Queen Square, London, England

The characteristics of stroke in baboons produced by transcranial occlusion of the middle cerebral artery were studied by clinical examination and serial cinematographic studies, the animals being maintained for three years following the stroke. The characteristic deficit in all animals was an initial, fairly dense faciobrachial weakness with, in a few instances, some accompanying leg weakness for a few days, rapidly improving over the first few months. Some animals retained very evident arm weakness; most animals retained weakness of the face; the majority showed recovery of reaching and placing reactions and some movement in all joints ofthe upper limb, although fine movements of the fingers remained invariably impaired. Homonymous hemianopia, at least to attention, also appeared to be characteristic, but all of the animals recovered a normal gait and leaping was regained. The close correlation between this and human stroke appears to confirm that middle cerebral artery occlusion in the baboon is a reliable, repeatable and acceptable stroke model.

Key Words: baboon • middle cerebral artery occlusion • serial cinematographic studies • homonymous hemianopia

This article has been cited by other articles:

				L. M. Hamberg, G. J. Hunter, K. I. Maynard, C. Owen, P. P. Morris, C. M. Putman, C. Ogilvy, and R. G. Gonzalez Functional CT Perfusion Imaging in Predicting the Extent of Cerebral Infarction from a 3-Hour Middle Cerebral Arterial Occlusion in a Primate Stroke Model AJNR Am. J. Neuroradiol., June 1, 2002; 23(6): 1013 - 1021. [Abstract] [Full Text] [PDF]