This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by YATSU, F. M. Articles by LIAO, C-L Search for Related Content PubMed PubMed Citation Articles by YATSU, F. M. Articles by LIAO, C-L

(Stroke. 1975;6:678.)
© 1975 American Heart Association, Inc.

---

Energy Metabolism During Brain Ischemia

Stability During Reversible And Irreversible Damage

FRANK M. YATSU M.D.¹; L-W LEE PH.D.²; C-L LIAO PH.D.²

¹ Department of Neurology, University of Oregon School of Medicine, Portland, Oregon 97201
² Department of Neurology, University of California School of Medicine, San Francisco, California 94143

The permissible duration of brain ischemia without sustaining damage is short. Less clear are the mechanisms accounting for the vulnerability of brain to ischemic insults. Neurochemical factors implicated include impairment of energy synthesis by mitochondria and of energy-dependent processes such as synaptic transmission, ATPase activity, membrane conductance and altered protein and lipid synthesis. To clarify the vulnerability of energy metabolism, we investigated energy availability and synthesis in our model of global cerebral ischemia. Our studies evaluated in vitro mitochondrial ATP synthesis and the in vivo quantitation of the cortical adenylate pool. Results of our investigations support a growing body of evidence showing the energy state to be relatively stable to ischemia. We conclude that an energy-dependent process of brain is primarily vulnerable to ischemia.

Key Words: ATPase activity • anoxia-ischemia • oxidative phosphorylation • energy charge • ATP • global ischemia • AMP • ADP

This article has been cited by other articles:

				L. Fechter and Z Annau Toxicity of mild prenatal carbon monoxide exposure Science, August 12, 1977; 197(4304): 680 - 682. [Abstract] [PDF]