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(Stroke. 1975;6:715.)
© 1975 American Heart Association, Inc.

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Lactate and Pyruvate Concentrations, and Acid-Base Balance of Cerebrospinal Fluid in Experimentally Induced Intracerebral and Subarachnoid Hemorrhage in Dogs

TOMEI SUGI M.D.¹; MASATOSHI FUJISHIMA M.D.¹; TERUO OMAE M.D.¹

¹ Department of Internal Medicine, The Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka City 812, Japan

The effect of blood injected into either subarachnoid space or subcortical brain tissue upon lactate and pyruvate concentrations as well as acid-base balance of cerebrospinal fluid (CSF) was studied in the anesthetized dog.

CSF lactate and lactate/pyruvate ratio (L/P ratio) increased progressively following the intracranial injection of blood and reached the maximum level at six hours after injection. These changes were significantly greater in animals with intracerebral hematoma than in those with subarachnoid hemorrhagic (SAH). An increase in CSF lactate and L/P ratio in hemorrhagic CSF seems to be caused by two different factors. Shed blood cells per se produce lactate and pyruvate, and blood in the subarachnoid space and intracerebral hematomas cause secondary changes in brain tissue metabolism by a probable reduction of cerebral blood flow. Therefore, an increase in CSF lactate with a concomitant rise in CSF L/P ratio is a useful indicator for brain tissue hypoxia, even when CSF is hemorrhagic.

The association of an increase in CSF lactate to a disproportionate decrease in CSF HCO₃^- was also observed in these animals.

Key Words: lactate/pyruvate ratio • anaerobic glycolysis • cerebral hypoxia