This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by LITTLE, J. R. Articles by SUNDT, T. M. Search for Related Content PubMed Articles by LITTLE, J. R. Articles by SUNDT, T. M., JR.

(Stroke. 1976;7:25.)
© 1976 American Heart Association, Inc.

---

Microcirculatory Obstruction in Focal Cerebral Ischemia: An Electron Microscopic Investigation in Monkeys

JOHN R. LITTLE M.D.¹; FREDERICK W. L. KERR M.D.¹; THORALF M. SUNDT JR. M.D.¹

¹ Cerebrovascular Clinical Research Center and the Department of Neurologic Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901

The fine structure of the microvasculature in areas of focal cerebral ischemia was studied in squirrel monkeys and the changes in areas of impaired and unimpaired microvascular filling, as defined by carbon perfusion, were compared. Microcirculatory obstruction became evident three hours following middle cerebral artery (MCA) occlusion and appeared to be partly the result of compression of capillaries by perivascular glial swelling and developing cerebral edema. Slight endothelial swelling was a common finding. Intraluminal membrane-bound bodies were occasionally identified but they did not appear to be producing significant obstruction. The tight endothelial junctions remained intact and there was no evidence of accelerated micropinocytosis. Severe neuronal injury frequently preceded the development of the microvascular obstruction and was more widespread than the zones of impaired perfusion.

This article has been cited by other articles:

				G. J DEL ZOPPO, R. VON KUMMER, and G. F HAMANN Ischaemic damage of brain microvessels: inherent risks for thrombolytic treatment in stroke J. Neurol. Neurosurg. Psychiatry, July 1, 1998; 65(1): 1 - 9. [Full Text]

				G. Rordorf, S. C. Cramer, J. T. Efird, L. H. Schwamm, F. Buonanno, and W. J. Koroshetz Pharmacological Elevation of Blood Pressure in Acute Stroke : Clinical Effects and Safety Stroke, November 1, 1997; 28(11): 2133 - 2138. [Abstract] [Full Text]