Stroke, Vol 7, 46-53, Copyright © 1976 by American Heart Association
Y Yamori, R Horie, H Handa, M Sato and M Fukase
The predilection sites of cerebrovascular lesions (cerebral hemorrhage
and/or softening) were studied in 1,278 stroke-prone spontaneously
hypertensive rats (SHRSP). The precise supply to the main cerebral arteries
was determined by trypan blue injections and microangiography. The three
major territories were the anteromedial cortex, the occipital cortex, and
the basal ganglia. A common angioarchitectural characteristic of these
three areas was the blood supply through "recurrent branching" from the
main stream. In the basal ganglia, where there is a preponderance of
lesions, the arteries responsible for these lesions belonged to the lateral
group of lenticulostriate arteries. The primary pre-stroke arterial lesions
were further studied microangiographically in SHRSP killed at the time the
initial symptoms of stroke were detected. These points were located at the
"boundary zone" of the main cerebral arteries. Our findings indicated the
importance of these two angioarchitectural minor loci as the basis for
functional or organic circulatory disturbances that may cause stroke. Since
these local factors of stroke are common in the cortex and basal ganglia of
rats and basal ganglia of humans, these SHRSP are regarded as good
pathogenetic models for studies on stroke in humans.
ARTICLES
Pathogenetic similarity of strokes in stroke-prone spontaneously hypertensive rats and humans
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