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Stroke, Vol 7, 291-295, Copyright © 1976 by American Heart Association

ARTICLES

Effect of beta-adrenergic blockade with propranolol on cerebral blood flow, autoregulation and CO2 responsiveness

M Aqyagi, VD Deshmukh, JS Meyer, Y Kawamura and Y Tagashira

Cerebral autoregulation and vasomotor responsiveness to carbon dioxide were measured quantitatively in normal baboons and after intravertebral or intravenous of the beta-adrenergic blocking agent, propranolol hydrochloride (Inderal). Continuous measurements were made of cerebral blood flow (CBF: measured as bilateral internal jugular venous outflow using an electromagnetic flowmeter), cerebral perfusion pressure (CPP), arterial Po2 and Pco2 and venous Po2, cerebral arteriovenous oxygen difference and endotracheal Pco2. The autoregulation index (A.I. = deltaCBF/deltaCPP) and the chemical index (C.I.= deltaCBF/deltaPaco2), were used as quantitative measures.

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				O. Z. Chi, X. Liu, and H. R. Weiss The Effects of Propranolol on Heterogeneity of Rat Cerebral Small Vein Oxygen Saturation Anesth. Analg., September 1, 1999; 89(3): 690 - 690. [Abstract] [Full Text] [PDF]