This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Symon, L. Articles by Strong, A. J. Search for Related Content PubMed PubMed Citation Articles by Symon, L. Articles by Strong, A. J.

Stroke, Vol 7, 547-554, Copyright © 1976 by American Heart Association

ARTICLES

Autoregulation in acute focal ischemia. An experimental study

L Symon, NM Branston and AJ Strong

The autoregulatory capacity of areas of the cerebral circulation subjected to ischemia by acute middle cerebral occlusion has been assessed in experimental primates. Autoregulation was tested to a rise in blood pressure induced by aramine, and to a fall in blood pressure induced by exsanguination. Whole hemisphere autoregulation was substantially disturbed due to both increased blood pressure and lowered blood pressure, but fractionation of this response indicated that autoregulation to increased blood pressure was preserved in the parasagittal and intermediate zones of the hemisphere, and totally lost in the region of the sylvian opercula where middle cerebral occlusion had produced the most dense ischemia. In relation to reduced perfusion pressure, autoregulation was again widely impaired and assessment of the degree of impairment by areas indicated no significant difference between the areas of the sylvian opercula and the remainder of the lateral aspect of the hemisphere studied. Where the degree of ischemia in each individual electrode was assessed, however, it appeared that the degree of auto-regulatory loss to decreased perfusion pressure was dependent upon the intensity of ischemia, and autoregulation was partially preserved in electrodes whose immediate post-occulsion flow values were greater than 40% of basal flow. Retransfusion following exsanguination in animals with acute middle cerebral occlusion indicated that there was a linear relationship between the degreee of reperfusion achieved by retransfusion and the intensity of ischemia induced by exsanguination following middle cerebral occlusion. Thus there was some support for the no-reflow phenomenon in intensely ischemic areas.

This article has been cited by other articles:

				H. K. Shin, M. Nishimura, P. B. Jones, H. Ay, D. A. Boas, M. A. Moskowitz, and C. Ayata Mild Induced Hypertension Improves Blood Flow and Oxygen Metabolism in Transient Focal Cerebral Ischemia Stroke, May 1, 2008; 39(5): 1548 - 1555. [Abstract] [Full Text] [PDF]

				C. Dohmen, B. Bosche, R. Graf, T. Reithmeier, R.-I. Ernestus, G. Brinker, J. Sobesky, and W.-D. Heiss Identification and Clinical Impact of Impaired Cerebrovascular Autoregulation in Patients With Malignant Middle Cerebral Artery Infarction Stroke, January 1, 2007; 38(1): 56 - 61. [Abstract] [Full Text] [PDF]

				H S Markus Cerebral perfusion and stroke J. Neurol. Neurosurg. Psychiatry, March 1, 2004; 75(3): 353 - 361. [Abstract] [Full Text] [PDF]

				L. M. Hamberg, G. J. Hunter, K. I. Maynard, C. Owen, P. P. Morris, C. M. Putman, C. Ogilvy, and R. G. Gonzalez Functional CT Perfusion Imaging in Predicting the Extent of Cerebral Infarction from a 3-Hour Middle Cerebral Arterial Occlusion in a Primate Stroke Model AJNR Am. J. Neuroradiol., June 1, 2002; 23(6): 1013 - 1021. [Abstract] [Full Text] [PDF]

				A. Rebel, C. Lenz, H. Krieter, K. F. Waschke, K. Van Ackern, and W. Kuschinsky Oxygen delivery at high blood viscosity and decreased arterial oxygen content to brains of conscious rats Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2591 - H2597. [Abstract] [Full Text] [PDF]

				F. Bari, T. M. Louis, D. W. Busija, and W. J. Pearce Effects of Ischemia on Cerebral Arteriolar Dilation to Arterial Hypoxia in Piglets • Editorial Comment Stroke, January 1, 1998; 29(1): 222 - 228. [Abstract] [Full Text] [PDF]