This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Olesen, J. Search for Related Content PubMed PubMed Citation Articles by Olesen, J.

Stroke, Vol 7, 566-569, Copyright © 1976 by American Heart Association

ARTICLES

Effect of intracarotid prostaglandin E1 on regional cerebral blood flow in man

J Olesen

The effect of prostaglandin E1 on regional cerebral blood flow (rCBF) was studied with the intra-arterial 133Xe method in ten awake patients under local anesthesia. Measurements were taken from 16 areas of a hemisphere in seven patients, from 35 areas of a hemisphere in two patients and from 256 areas of a hemisphere in one patient. The prostaglandin was dissolved from the crystalline state without the aid of alcohol. It was given intracarotidly as a constant infusion at a rate of 5 ng per kilogram per minute for five minutes before the measurement and continued during the measurement. In every patient a mild increase in blood flow during the prostaglandin infusion was seen. The flow increase took place in all parts of the hemisphere. It averaged 11.2% (p less than 0.01). During the infusion, the skin supplied by the internal carotid artery and the conjunctiva on the infused side became red and sometimes swollen. A slight pressure was noted by most patients, but none had pain. No side effects of the infusion were noted.

This article has been cited by other articles:

				M. Takenaka, H. Iida, M. Iida, M. Uchida, and S. Dohi The Comparative Effects of Prostaglandin E1 and Nicardipine on Cerebral Microcirculation in Rabbits Anesth. Analg., April 1, 2003; 96(4): 1139 - 1144. [Abstract] [Full Text] [PDF]