Stroke, Vol 7, 599-607, Copyright © 1976 by American Heart Association
H Okada, H Horibe, O Yoshiyuki, N Hayakawa and N Aoki
An epidemiological study of cerebrovascular disease in Akabane and Asahi,
Japan, was made. (These cities are located near Nagoy, Japan.) The study
population included 4,737 men and women aged 40 to 79 at the time of entry
into the study. There were 4,186 persons who were examined and, of these,
264 cases of cerebrovascular attacks were observed between 1964 and 1970.
The incidence rate of stroke in those persons not responding to the survey
was 15.9 times higher than in those persons examined according to
person-year observation in Akabane. The risk factors for cerebral
hemorrhage and thrombosis were evaluated by age-adjusted and sex-adjusted
relative risks. The predisposing factors to cerebral hemorrhage appeared to
be high blood pressure, high left R wave, ST depression, T abnormality,
capillary fragility counts, previous medical history of stroke and
albuminuria. For cerebral thrombosis, the predisposing factors appeared to
be high blood pressure, ST depression and funduscopic sclerotic findings,
and those factors assumed to be significant were glycosuria and smoking
habits. Ocular funduscopic abnormality was the most prominent risk factor
for cerebral thrombosis, while high blood pressure and ECG abnormalities
were highly related to cerebral hemorrhage. It was suggested that those
subjects with a relatively higher blood pressure may have a higher relative
risk of cerebral hemorrhage than those with a lower (normal range) blood
pressure. A previous or family history of stroke also appeared
significantly related to cerebral hemorrhage.
ARTICLES
A prospective study of cerebrovascular disease in Japanese rural communities, Akabane and Asahi. Part 1: evaluation of risk factors in the occurrence of cerebral hemorrhage and thrombosis
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