Stroke, Vol 7, 618-625, Copyright © 1976 by American Heart Association
A Schettini and WW Furniss
The influence of papaverine on the intracranial system of the dog was
studied by measuring the pressure-depth-time response for the intact
intracranial system, i.e., for the subarachnoid and subpial compartments.
This was accomplished by a measurement system which provided an accurate
pressure-depth determination and a uniform rate of transducer insertion.
Distinct regions of the intracranial system (subarachnoid, transitional,
and subpial) were identified from inflections in the pressure response
curve. The test parameter, brain relative stiffness (BRS), was obtained by
determining the slope of the pressure response values within the subpial
region. This parameter is a measure of the "stiffness" or elasticity of
bring tissue within the test configuration. A bolus injection of papaverine
(1 mg per kilogram, i.v.) caused an increase in the transitional region, a
compensatory reduction in the subarachnoid space, and an increase in BRS.
It is postulated that at normotensive arterial blood pressure,
cerebrovascular expansion caused by papaverine resulted in increased brain
tissue elasticity, i.e., an increase in the pressure-depth response for the
subpial region. Possible implications for this increase are discussed.
Experiments should be conducted in which local blood flow studies are
coupled with measurements of brain elastic response.
ARTICLES
Dynamic response of the intracranial system in the conscious dog to papaverine hydrochloride