Stroke, Vol 8, 301-314, Copyright © 1977 by American Heart Association
WS Fields, NA Lemak, RF Frankowski and RJ Hardy
Adouble-blind trial of aspirin for the treatment of cerebral ischemia was
begun in 1972 and continued for 37 months. This was accomplished despite
difficulties in controlling a long-term study of a drug which has
widespread availability and consumption. The study design, criteria for
selection of patients, follow-up surveillance, and methods of data analysis
are presented. We report only subjects without carotid surgery before
randomization. Patients (178) who had carotid transient ischemic attacks
(TIAs) were randomly allocated to aspirin or placebo and followed to
determine the incidence of subsequent TIAs,death, cerebral infarction or
retinal infarction. Analysis of the first six months of follow-up revealed
a statistically significant differential in favar of aspirin when death or
cerebral or retinal infarction and the occurrence of TIAs were grouped and
considered together as end points. Significance in favor of aspirin
treatment was mainly revealed in patients with a history of multiple TIAs
and was most evident in those individuals having carotid lesions
appropriate to the TIA symptoms. It cannot be inferred from this study that
aspirin prevents stroke because when end points were restriced to death or
cerebral or retinal infarction, there was no statistically significant
differential between the aspirin and placebo treatments.
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Controlled trial of aspirin in cerebral ischemia
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