This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Mendelow, A. D. Articles by Rosendorff, C. Search for Related Content PubMed PubMed Citation Articles by Mendelow, A. D. Articles by Rosendorff, C.

Stroke, Vol 8, 326-328, Copyright © 1977 by American Heart Association

ARTICLES

Cerebrovascular response to infused 5-hydroxytryptamine in the baboon. Part 2. 5 Hydroxytryptamine infusion in estrogen and progesterone treated animals

AD Mendelow, BH Eidelman, TA McCalden and C Rosendorff

The effect of intracarotid infusion of 5-hydroxytryptamine (5-HT) on cerebral blood flow was studied in five female baboons 7 days after intramuscular injection of slow release estrogen and progesterone. The control values for total cerebral blood flow, grey matter flow, and white matter flow were 38.9, 57.5, and 11.0 ml/min/100 gm of tissue respectively. There was a statistically significant decrease in total, grey and white matter blood flow during infusion of 5-HT at dosages ranging from 0.5 to 10.0 microng/kg/min. The study indicates that in female baboons pretreated with estrogen and progesterone, intracarotid infusion of 5-HT produces a dose dependent decrease in cerebral blood flow, which did not occur in control animals.