Stroke, Vol 8, 358-360, Copyright © 1977 by American Heart Association
HA Kontos, AJ Raper and JL Patterson
The mechanism by which the local effect of CO2ON pial arterioles is exerted
was examined in anesthetized cats equipped with a cranial window for the
direct observation of the microcirculation of the parietal cortex. The
dilation of pial arterioles in response to application of artificial
cerebrospinal fluid with low pH was the same whether or not the PCO2 of the
solution was maintained in the normal range or markedly increased. The
constriction of pial arterioles in response to application of artificial
cerebrospinal fluid with high pH was the same whether or not the PCO2 of
the solution was maintained in the normal range or markedly decreased.
Finally, pial arterioles did not change their caliber in response to
application of cerebrospinal fluid with unchanged pH but markedly increased
or decreased Pco, or bicarbonate ion concentration. These results show that
the action of CO2 on cerebral vessels is exerted via changes in
extracellular fluid pH and that molecular CO2 and bicarbonate ions do not
have independent vasoactivity on these vessels.
ARTICLES
Analysis of vasoactivity of local pH, PCO2 and bicarbonate on pial vessels
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