This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ellis, E. F. Articles by Oates, J. A. Search for Related Content PubMed PubMed Citation Articles by Ellis, E. F. Articles by Oates, J. A.

Stroke, Vol 8, 480-483, Copyright © 1977 by American Heart Association

ARTICLES

Cerebral arterial smooth muscle contraction by thromboxane A2

EF Ellis, AS Nies and JA Oates

The contractile effects of thromboxane A2 (TxA2), a labile arachidonic acid metabolite, were studied in arterial smooth muscle strips. TxA2 was generated upon the addition of 255 nM prostaglandin cyclic endoperoxide H2 to human platelet particles in the muscle bath. Using the isometric contaction produced by 40 mM K+ in isotonic saline as the reference contraction, bovine middle cerebral artery strips contracted to 153 +/- 14% of the reference response while bovine coronary and porcine coronary, renal and common carotid strips contracted to 47 +/- 3, 26 +/- 5, 43 +/- 2 and 2 +/- 1% of reference, respectively. The cerebral artery response to the TxA2 generating system was as great as the maximum response to prostaglandin F2alpha and two times the maximum response to 5-hydroxytryptamine. Because TxA2 is formed by brain tissue and released from aggregating platelets, it may be important in the pathogenesis of spasm associated with injured brain tissue or pathologic changes leading to platelet aggregation.

This article has been cited by other articles:

				T. Kato, Y. Goto, S. Yoneda, K. Yamamoto, and O. Aochi Effects of Prostaglandin I2 and a Selective Thromboxane Synthetase Inhibitor on the Arteriolar Constriction Caused by Norepinephrine Angiology, August 1, 1990; 41(8): 589 - 594. [Abstract] [PDF]

				T. Motomiya, O. Matsuba, and H. Yamazaki Constriction and Damage of the Pulmonary Artery by Induced Intravascular Aggregation of Platelets Vascular and Endovascular Surgery, September 1, 1979; 13(5): 303 - 312. [PDF]