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Stroke, Vol 9, 10-12, Copyright © 1978 by American Heart Association

ARTICLES

Dose dependency of the post-insult protective effect of pentobarbital in the canine experimental stroke model

G Corkill, S Sivalingam, JA Reitan, BA Gilroy and MG Helphrey

In a canine stroke model, dose dependent protection by postocclusion pentobarbital was suggested from 10--40 mg/kg. In 28 dogs investigated (10 from a previous study) a distinct, significant reduction in right cerebral hemisphere infarction occurred in animals given 15--20 mg/kg pentobarbital intramuscularly 1 hour postocclusion. Increased dosages did not alter statistically the infarct size and 2 dogs at the 50 mg/kg and 80 mg/kg levels died of barbiturate-induced respiratory failure.

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