This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Santambrogio, S. Articles by Randazzo, A. Search for Related Content PubMed PubMed Citation Articles by Santambrogio, S. Articles by Randazzo, A.

Stroke, Vol 9, 130-132, Copyright © 1978 by American Heart Association

ARTICLES

Is there a real treatment for stroke? Clinical and statistical comparison of different treatments in 300 patients

S Santambrogio, R Martinotti, F Sardella, F Porro and A Randazzo

In the absence of universally accepted criteria for the medical treatment of stroke, we made a rigorously randomized comparative study of different treatments in 300 patients. One group of patients received only a general supportive treatment designed to ensure adequate supplies of water, electrolytes and calories, plus whatever was needed to prevent infection and correct extant associated pathology. Three other groups of patients were treated in the same way but were also given, respectively, one of the following medications: Hydergine (Sandoz) (a mixture of three ergot alkaloids), dexamethasone, and mannitol. No statistically significant difference emerged among any of the treatment groups and the reference group in terms of objective therapeutic results. The authors concluded that, at least with the dosage used in this study, none of the treatments proved more useful than conventional supportive therapy in the first 10 days after a stroke.

This article has been cited by other articles:

				J. Bardutzky and S. Schwab Antiedema Therapy in Ischemic Stroke Stroke, November 1, 2007; 38(11): 3084 - 3094. [Abstract] [Full Text] [PDF]

				D. Bereczki, L. Mihalka, S. Szatmari, K. Fekete, D. Di Cesar, B. Fulesdi, L. Csiba, and I. Fekete Mannitol Use in Acute Stroke: Case Fatality at 30 Days and 1 Year Stroke, July 1, 2003; 34(7): 1730 - 1735. [Abstract] [Full Text] [PDF]

				D. Bereczki, M. Liu, G. F. d. Prado, and I. Fekete Cochrane Report : A Systematic Review of Mannitol Therapy for Acute Ischemic Stroke and Cerebral Parenchymal Hemorrhage Stroke, November 1, 2000; 31(11): 2719 - 2722. [Abstract] [Full Text] [PDF]

				P DESAI and K PRASAD Dexamethasone is not necessarily unsafe in primary supratentorial intracerebral haemorrhage J. Neurol. Neurosurg. Psychiatry, November 1, 1998; 65(5): 799a - 801. [Full Text]

				G.G. Nenci, P. Gresele, M. Taramelli, G. Agnelli, and E. Signorini Thrombolytic Therapy for Thromboembolism of Vertebrobasilar Artery Angiology, September 1, 1983; 34(9): 561 - 571. [Abstract] [PDF]