This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fields, W. S. Articles by Hardy, R. J. Search for Related Content PubMed PubMed Citation Articles by Fields, W. S. Articles by Hardy, R. J.

Stroke, Vol 9, 309-319, Copyright © 1978 by American Heart Association

ARTICLES

Controlled trial of aspirin in cerebral ischemia. Part II: surgical group

WS Fields, NA Lemak, RF Frankowski and RJ Hardy

Patients (125) who had carotid transient ischemic attacks (TIAs) and one or more accessible carotid lesions visualized angiographically had reconstructive operations of the carotid artery and were then randomly assigned to aspirin or placebo treatment. The were followed to determine the incidence of subsecquent TIAs, death, cerebral infarction, or retinal infarction. Life table analysis (for 24 months follow up) that eliminated deaths which were not stroke-related revealed a significant difference in favor of aspirin. Because of the small number of patients and the short period of follow up, these results should be interpreted only as consistent with those reported in the initial publication but not conclusive of an aspirin effect in preventing cerebral infarction.

This article has been cited by other articles:

				M. Sobel and R. Verhaeghe Antithrombotic Therapy for Peripheral Artery Occlusive Disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest, June 1, 2008; 133(6_suppl): 815S - 843S. [Abstract] [Full Text] [PDF]

				P. B. Gorelick and S. M. Weisman Risk of Hemorrhagic Stroke With Aspirin Use: An Update Stroke, August 1, 2005; 36(8): 1801 - 1807. [Abstract] [Full Text] [PDF]

				G. P. Clagett, M. Sobel, M. R. Jackson, G. Y. H. Lip, M. Tangelder, and R. Verhaeghe Antithrombotic Therapy in Peripheral Arterial Occlusive Disease: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy Chest, September 1, 2004; 126(3_suppl): 609S - 626S. [Abstract] [Full Text] [PDF]

				J. L. Stork, C. R. Levi, B. R. Chambers, A. L. Abbott, and G. A. Donnan Possible Determinants of Early Microembolism After Carotid Endarterectomy Stroke, August 1, 2002; 33(8): 2082 - 2085. [Abstract] [Full Text] [PDF]

				M. R. Jackson and G. P. Clagett Antithrombotic Therapy in Peripheral Arterial Occlusive Disease Chest, January 1, 2001; 119(1_suppl): 283S - 299S. [Full Text] [PDF]

				K. A. SEVARINO, A. OLIVETO, and T. R. KOSTEN Neurobiological Adaptations to Psychostimulants and Opiates as a Basis of Treatment Development Ann. N.Y. Acad. Sci., January 1, 2000; 909(1): 51 - 87. [Abstract] [Full Text] [PDF]

				E. S. Johnson, S. F. Lanes, C. E. Wentworth III, M. H. Satterfield, B. L. Abebe, and L. W. Dicker A Metaregression Analysis of the Dose-Response Effect of Aspirin on Stroke Arch Intern Med, June 14, 1999; 159(11): 1248 - 1253. [Abstract] [Full Text] [PDF]

				A. G Thrift, J. J McNeil, A. Forbes, and G. A Donnan Risk of primary intracerebral haemorrhage associated with aspirin and non-steroidal anti-inflammatory drugs: case-control study BMJ, March 20, 1999; 318(7186): 759 - 764. [Abstract] [Full Text]

				J. He, P. K. Whelton, B. Vu, and M. J. Klag Aspirin and Risk of Hemorrhagic Stroke: A Meta-analysis of Randomized Controlled Trials JAMA, December 9, 1998; 280(22): 1930 - 1935. [Abstract] [Full Text] [PDF]

				M. Eccles, N. Freemantle, J. Mason, and t. N. o. E. A. G. D. Group North of England evidence based guideline development project: guideline on the use of aspirin as secondary prophylaxis for vascular disease in primary care BMJ, April 25, 1998; 316(7140): 1303 - 1309. [Full Text]

				J. Biller, W. M. Feinberg, J. E. Castaldo, A. D. Whittemore, R. E. Harbaugh, R. J. Dempsey, L. R. Caplan, T. F. Kresowik, D. B. Matchar, J. F. Toole, et al. Guidelines for Carotid Endarterectomy : A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association Circulation, February 10, 1998; 97(5): 501 - 509. [Full Text] [PDF]

				J. Biller, W. M. Feinberg, J. E. Castaldo, A. D. Whittemore, R. E. Harbaugh, R. J. Dempsey, L. R. Caplan, T. F. Kresowik, D. B. Matchar, J. F. Toole, et al. Guidelines for Carotid Endarterectomy : A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association Stroke, February 1, 1998; 29(2): 554 - 562. [Full Text] [PDF]

				H. Nishimura, H. Naritomi, Y. Iwamoto, H. Tachibana, and M. Sugita In Vivo Evaluation of Antiplatelet Agents in Gerbil Model of Carotid Artery Thrombosis Stroke, June 1, 1996; 27(6): 1099 - 1104. [Abstract] [Full Text]

				B. Aspey and M. Harrison Sex differences in the antithrombotic effectiveness of aspirin Vascular Medicine, September 1, 1990; 1(2): 113 - 119. [PDF]

				W. R. Slade JR, S. Enker, R. Borras, and Jia Rhon Chen The Underlying Problems Resulting in Controversies in the Clinical Management of Transient Ischemic Attacks: An Overview Angiology, October 1, 1983; 34(10): 639 - 645. [Abstract] [PDF]