This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shinohara, Y. Articles by Takagi, S. Search for Related Content PubMed PubMed Citation Articles by Shinohara, Y. Articles by Takagi, S.

Stroke, Vol 9, 504-508, Copyright © 1978 by American Heart Association

ARTICLES

Cerebral hemodynamics in Shy-Drager syndrome: variability of cerebral blood flow dysautoregulation and the compensatory role of chemical control in dysautoregulation

Y Shinohara, F Gotoh and S Takagi

Cerebrovascular autoregulation and CO2 reactivity were measured repeatedly in 3 patients with the multiple system atrophy type of autonomic insufficiency (Shy-Drager syndrome) by means of the 133Xe injection method. The degree of cerebral blood flow (CBF) dysautoregulation showed day-to-day variations in 2 of the 3 patients. The CO2 reactivity was normal or supernormal in the supine position in patients with impaired autoregulation. In the head-up position the response to CO2 was slightly suppressed in 2 of the patients, suggesting that chemical control may have tended to compensate for CBF dysautoregulation. It is concluded that the mechanism of chemical control of the cerebrovasculature is different from that which controls autoregulation and may have partially compensated for CBF dysautoregulation.

This article has been cited by other articles:

				J. M. Serrador, F. A. Sorond, M. Vyas, M. Gagnon, I. D. Iloputaife, and L. A. Lipsitz Cerebral pressure-flow relations in hypertensive elderly humans: transfer gain in different frequency domains J Appl Physiol, January 1, 2005; 98(1): 151 - 159. [Abstract] [Full Text] [PDF]

				R. L. Bondar, P. T. Dunphy, P. Moradshahi, M. S. Kassam, A. P. Blaber, F. Stein, and R. Freeman Cerebrovascular and Cardiovascular Responses to Graded Tilt in Patients With Autonomic Failure Stroke, September 1, 1997; 28(9): 1677 - 1685. [Abstract] [Full Text]