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Published Online
on September 27, 2007

Stroke. 2007
Published online before print September 27, 2007, doi: 10.1161/STROKEAHA.107.490581
A more recent version of this article appeared on November 1, 2007
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Submitted on April 12, 2007
Accepted on May 1, 2007

Analysis of Calcium in Carotid Plaques With Agatston Scores for Appropriate Selection of Surgical Intervention

Hiroyuki Katano MD, PhD* and Kazuo Yamada MD, PhD

From the Departments of Neurosurgery, and Medical Informatics and Integrative Medicine, Nagoya City University Graduate School of Medical Sciences, Japan.

* To whom correspondence should be addressed. E-mail: katano{at}med.nagoya-cu.ac.jp.

Background and Purpose—The aim of the study was to determine whether the Agatston calcium score might be applied as a useful tool for evaluation of carotid stenosis.

Methods—A total of 124 carotid bifurcations were examined with multidetector row CT. Calcium scores were determined according to the method described by Agatston et al.

Results—Agatston scores generally appear appropriate for evaluation of calcified plaques. Calcified lesions with bigger differences between mean and peak Hounsfield unit (HU) in single cases accounted for only 34.3% of those with volume scores under 500 mm3, whereas 81.3% (P<0.001) for those sized >500 mm3.

Conclusions—The Agatston calcium score is useful in evaluating carotid plaques with calcium. We recommend, however, individual analyses for quality (hardness) and quantity (volume) of each large calcified focus (>500 mm3) by multidetector row CT lesions in order to provide indications for surgical treatment of carotid stenosis, carotid endarterectomy or carotid artery stenting.
Key words: Agatston calcium score • atherosclerosis • carotid artery stenting • carotid endarterectomy • carotid plaque • carotid stenosis






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