on June 11, 2009
Published online before print June 11, 2009, doi: 10.1161/STROKEAHA.109.551747
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Submitted on March 11, 2009
From the First Affiliated Hospital (L.W., X.L., X.T.), Medical College of Shantou University, Shantou, China; the Laboratory of Human Genetics (Y.S., X.L., X.W.), Beijing Hypertension League Institute, Beijing, China; the National Research Institute for Family Planning (X.M.), Beijing, China; the Department of Epidemiology (B.X., J.M.), Capital Institute of Pediatrics, Beijing, China; and the Roche Center for Medical Genomics (K.L.), F. Hoffmann-La Roche Ltd, Basel, Switzerland. * To whom correspondence should be addressed. E-mail: tanxuerui{at}vip.sina.com
or xingyuw{at}yahoo.com.
Background and Purpose—PRKCH (the gene encoding protein kinase C Methods—A total of 1209 patients with stroke and 1174 controls were examined using a case–control methodology. The 1425G/A SNP in PRKCH was genotyped by allele-specific real-time PCR assay. Results—The 1425G/A SNP in PRKCH was significantly associated with both ischemic stroke (odds ratio [OR]=1.31; 95% confidence interval [CI], 1.08 to 1.60; P=0.0058) and cerebral hemorrhage (OR=1.94; 95% CI, 1.21 to 3.10; P=0.0054) under a dominant model. Even after age- and sex-adjustment, the significant associations remained (in ischemic stroke, for AA+AG versus GG, OR=1.37, 95% CI, 1.12 to 1.67, P=0.0019; in cerebral hemorrhage, for AA+AG versus GG, OR=1.96, 95% CI, 1.21 to 3.19, P=0.0064). Conclusions—The 1425G/A SNP in PRKCH increases the risk of both ischemic stroke and cerebral hemorrhage in the Chinese population.
Revised on May 3, 2009
Accepted on May 8, 2009
The 1425G/A SNP in PRKCH Is Associated With Ischemic Stroke and Cerebral Hemorrhage in a Chinese Population
Lijun Wu PhD;
) has a role in the pathogenesis of ischemic stroke. The 1425G/A SNP in PRKCH (rs2230500) is significantly associated with ischemic stroke in Japanese. The aim of the present study is to investigate the associations in ischemic stroke and other types of stroke in the Chinese population.
Key words: ischemic stroke • cerebral hemorrhage • PRKCH