on November 5, 2009
Published online before print November 5, 2009, doi: 10.1161/STROKEAHA.109.568469
Submitted on September 21, 2009
From the Stroke Research Group (S.M.G., M.M.B., H.R.J., T.A.Y., D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK; and the Medical Statistics Unit (CK), London School of Hygiene and Tropical Medicine, London, UK. * To whom correspondence should be addressed. E-mail: d.werring{at}ion.ucl.ac.uk.
Background and Purpose—Little is known about the development of cerebral microbleeds in patients with ischemic stroke. We studied the incidence of new microbleeds in a cohort of patients with ischemic stroke or transient ischemic attack screened for microbleeds at baseline. Methods—Twenty-one surviving patients with ischemic stroke or transient ischemic attack were followed up after a mean interval of 5.5 years with repeat MRI and clinical assessment. Predictors of new microbleeds were tested in logistic regression. Results—Of patients with microbleeds at baseline, 50% had new microbleeds at follow-up compared with 8% of those without baseline microbleeds (P=0.047). The presence of microbleeds at baseline predicted new microbleeds (OR, 12; 95% CI, 1.02 to 141.34; P=0.048), as did mean systolic blood pressure (OR, 1.28 per unit increase; 95% CI, 1.23 to 1.33; P<0.001). One patient had a stroke (intracerebral hemorrhage) during follow-up. Conclusions—Patients with ischemic stroke or transient ischemic attack are at risk of developing new microbleeds over 5.5 years, despite most surviving patients remaining clinically stable. Systolic blood pressure is the strongest predictor of microbleed development; better control of hypertension may help prevent new microbleed formation.
Accepted on October 1, 2009
MRI Detection of New Microbleeds in Patients With Ischemic Stroke. Five-Year Cohort Follow-Up Study
Simone M. Gregoire MD;
Key words: gradient echo MRI • intracerebral hemorrhage • microbleeds • small vessel disease • stroke