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(Stroke. 1997;28:1650-1656.)
© 1997 American Heart Association, Inc.

Articles

Abstracts of Literature

Askiel Bruno Linda S. Williams

	Cerebral Aneurysms

 
AB-13838-97
Intraarterial Infusion of Papaverine in Experimental Cerebral Vasospasm—Fujiwara N (1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-07, Japan), Honjo Y, Ohkawa M, Tanabe M, Irie K, Nagao S, Takashima H, Satoh K, Kojima K—Am J Neuroradiol. 1997;18:255-262.

Purpose: To determine the effectiveness of intraarterial infusion of papaverine hydrochloride (PPV) in an experimental model of cerebral vasospasm and to measure the mean blood flow velocity of the middle cerebral artery (MCA). Methods: Seven Japanese monkeys were divided into three groups: those studied 3 days after surgery (the third-day group, n=3); those studied 7 days after surgery (the seventh-day group, n=3); and a control group (n=1). Vasospasm was induced in the experimental groups by placing a blood clot in the subarachnoid space around the top of the internal carotid siphon. PPV (5 mg/kg) was infused (over 60 minutes) into the internal carotid artery (ICA). The vascular diameters of the ICA and MCA were measured on angiograms before and after infusion. The mean blood flow velocity in the MCA was measured on transcranial Doppler sonograms before and 24 hours after infusion. After fixation, the MCA was dissected out, stained, and examined microscopically. Results: After vasospasm induction, both arteries were narrowed more than 30% in the third-day group and more than 50% in the seventh-day group. After PPV infusion in both groups, vascular dilatation of about 20% was seen. The mean increase in blood flow velocity in the third-day group (30%) was smaller than in the seventh-day group (70%). The mean blood flow velocity . . . [Full Text of this Article]