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(Stroke. 2008;39:2421.)
© 2008 American Heart Association, Inc.

Editorials

Stroke-Induced Sudden-Autonomic Death

Areas of Fatality Beyond the Insula

Max J. Hilz, MD, PhD Stefan Schwab, MD, PhD

From the Department of Neurology (M.J.H., S.S.), University Erlangen-Nuremberg, Erlangen, Germany; and the Departments of Neurology, Medicine, Psychiatry (M.J.H.), New York University, New York, NY, USA.

Correspondence to Max J. Hilz, MD, PhD, Departments of Neurology, Medicine, and Psychiatry, New York University, 550 First Ave, NB 7W11, New York, NY 10016, USA. E-mail max.hilz@med.nyu.edu

Key Words: acute stroke • cerebral infarct

An extract of the first 250 words of the full text is provided, because this article has no abstract.

See related article, pages 2425–2431.

Stroke is the third leading cause of death.^1,2 Fatal outcome has been primarily related to acute or chronic complications of stroke-induced executive deficits, such as muscle weakness, swallowing disorders, respiratory dysfunction with pneumonia, or cardiac complications.^3,4

Only during the last 10 or 15 years has there been an increasing interest in and knowledge of associations between cerebral lesions and altered influences of the central autonomic nervous system on cardiovascular and respiratory function.^5–7 Oppenheimer et al^8–10 suggested a role of the insular cortex in the pathophysiology of sudden death. The group extensively assessed topographically distinct interactions of the left and the right insular cortex with heart rate and blood pressure control.¹¹ There was agreement that insular cortex lesions essentially contribute to clinically relevant alterations of cardiovascular control.⁸

In this issue of Stroke, Rincon and coworkers present an analysis of associations between ischemic stroke location and fatal cardiac outcome, based on the epidemiological data of the Northern Manhattan Stroke study (NOMAS).^12,13 Considering neurological syndromes and neuroimaging findings, the authors analyzed outcome during a 5-year follow-up period. Mortality rates or nonfatal myocardial infarctions, and particularly sudden unexpected or unwitnessed death, were associated with the location of brain infarctions. Apart from age, male gender, the National Institutes of Health Stroke Scale (NIHSS), and a history of coronary artery disease, the authors identified infarct locations in the frontal, parietal, temporal lobe, and the insula as predictors of cardiac death as well as composite outcome of cardiac death or . . . [Full Text of this Article]

Related Article:

Stroke Location and Association With Fatal Cardiac Outcomes: Northern Manhattan Study (NOMAS)

Fred Rincon, Mandip Dhamoon, Yeseon Moon, Myunghee C. Paik, Bernadette Boden-Albala, Shunichi Homma, Marco R. Di Tullio, Ralph L. Sacco, and Mitchell S.V. Elkind
Stroke 2008 39: 2425-2431. [Abstract] [Full Text] [PDF]