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(Stroke. 2007;38:2025.)
© 2007 American Heart Association, Inc.

Editorials

Do Women Have Worse Outcome After Stroke Caused by Intracranial Arterial Stenosis?

Tatjana Rundek, MD, PhD

From Division of Stroke, Department of Neurology, Columbia University, New York, NY.

Correspondence to Tatjana Rundek, MD, PhD, Neurological Institute, NI-6, Department of Neurology, Columbia University, 710 West 168th Street, New York, NY 10032. E-mail tr89@columbia.edu

Key Words: minorities • outcome • women

An extract of the first 250 words of the full text is provided, because this article has no abstract.

See related article, pages 2055–2062.

Stroke affects both women and men, but it is the leading cause of mortality in women.¹ Although many aspects of the disease are similar in women and men, there is a growing body of evidence to support sex (a biologic status determined by sex chromosomes and sex hormones) and gender (sex determined by social, cultural, and educational context) differences in the epidemiology of stroke. Numerous reports have demonstrated sex-specific differences in the prevalence, clinical presentation, management, recanalization rate of intracranial artery stenosis after intravenous or intra-arterial thrombolysis in acute ischemic stroke, and clinical outcomes of stroke of all subtypes.^2–6 The results are, however, often conflicting and there is a paucity of randomized controlled trial support regarding sex-related stroke care delivery. The recent gender-specific analysis from the Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) study⁷ provided very important evidence that women with symptomatic intracranial arterial stenosis have considerable increased risk for stroke and vascular death than men. These data contrast a common perception that men have greater risk of recurrent stroke then women.

The WASID study had a good representation of women (38%), similar to the NINDS Stroke TPA study (42%),⁸ and the recent SPARCL study (40%),⁹ but in comparison to these studies showed a considerate gender-specific difference in stroke outcome. Women in the WASID study had more comorbidities (except coronary artery disease), higher body mass index and total cholesterol, were more sedentary but consumed less alcohol and cigarettes, had positive family history of stroke, and had . . . [Full Text of this Article]

Related Article:

Gender Differences in Outcomes Among Patients With Symptomatic Intracranial Arterial Stenosis

Janice E. Williams, Marc I. Chimowitz, George A. Cotsonis, Michael J. Lynn, Salina P. Waddy for the WASID Investigators
Stroke 2007 38: 2055-2062. [Abstract] [Full Text] [PDF]

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