From the Unit of Neuroepidemiology and Health Services Research, Division
of Neurology, Karolinska Institute, Huddinge University Hospital (L.W.H., L.
von K., V.K., K.J., J. de P.-C.), the Department of Physical Therapy,
Karolinska Institute (L.W.H., L. von K.), and Departments of Physical Therapy
(M.H.), Occupational Therapy (G.W.), Geriatric Medicine, Huddinge University
Hospital (H.T.), Stockholm, Sweden, and the Department of Applied
Epidemiology, National Centre for Epidemiology, Carlos III Institute of Health
(J.A., J. de P.-C.), Madrid, Spain.
Correspondence to Lotta Widén Holmqvist, Unit of Neuroepidemiology and Health Services Research, Division of Neurology, Karolinska Institute, Huddinge University Hospital, S-141 86 Huddinge, Sweden. E-mail lotwid{at}ki.se
MethodsThe patients were eligible if they were continent,
independent in feeding, had mental function within normal limits, and
had impaired motor function and/or aphasia 1 week after stroke.
Patients were randomized either to early supported discharge with
continuity of rehabilitation at home for 3 to 4 months or to routine
rehabilitation service in a hospital, day care, and/or outpatient care.
The home rehabilitation team consisted of two physical therapists, two
occupational therapists, and one speech therapist; one of the
therapists was assigned as case manager for the patient. The
rehabilitation program at home emphasized a task- and context-oriented
approach. The activities were chosen on the basis of the patient's
personal interests. Spouses were offered education and individual
counseling. A total of 81 patients were followed up for a minimum of 3
months. Patient outcome was assessed by the Frenchay Social Activity
Index, Extended Katz Index, Barthel Index, Lindmark Motor Capacity
Assessment, Nine-Hole Peg Test, walking speed over 10 m, reported
falls, and subjective dysfunction according to the Sickness Impact
Profile. Patient use of hospital and home rehabilitation service and
patient satisfaction with care were studied.
ResultsOverall there were no statistical significant
differences in outcome. Multivariate logistic
regression analysis suggested a systematic positive effect for
the home rehabilitation group in social activity, activities of daily
living, motor capacity, manual dexterity, and walking. A considerable
difference in resource use during such a 3-month period was seen. A
52% reduction in hospitalization was observed: from 29 days in the
routine rehabilitation group to 14 days in the home rehabilitation
group. Patient satisfaction was in favor of the latter group.
ConclusionsEarly supported discharge with continuity of
home rehabilitation services for the majority of moderately disabled
stroke patients during the first 3-month period after acute stroke is
not less beneficial than routine rehabilitation and can be a
rehabilitation service of choice if follow-up at 6 and 12 months
confirms the suggested effectiveness and considerable reduction in use
of health care.
In randomized controlled studies,3 4 specialized
rehabilitation units have been shown to achieve faster and better
functional outcome than general medical wards. Several
authors5 6 have suggested that there should be
more emphasis on home rehabilitation. However, the rationale of this
proposal is still unclear. In the United Kingdom, the Domino Study
Group7 reported no difference in outcome but
cheaper hospital-based outpatient rehabilitation, and the Bradford
cost-effectiveness study8 suggested that home
physiotherapy is more effective and cheaper.
The optimum combination of inpatient, outpatient, and/or home
rehabilitation is not known. The development of cost-effective
strategies in the area of stroke rehabilitation together with targeting
of patients will likely benefit from different organizational forms of
rehabilitation. A stroke service based on short-term admission to a
hospital, followed (where appropriate) by early supported discharge
with continuity of rehabilitation in the community, seems to have
several advantages, as it guarantees continuity both in time and
personnel and is possibly less expensive, as shown by our pilot
study.9 10 In a recent randomized controlled
study in Newcastle upon Tyne,11 where a total of
80 patients were followed up for 1 year after stroke, a similar scheme
was found to be feasible, yielding a saving in bed-days. To our
knowledge, no study has reported on the benefit of early discharge and
continuity of rehabilitation maintained in the community.
At the Department of Neurology at Huddinge Hospital in southwest
Stockholm, we have estimated the population-based need for late therapy
intervention after stroke12 and developed an
organizational model of home rehabilitation for moderately disabled
stroke patients hospitalized at the Department of Neurology, Huddinge
Hospital, which implied early supported discharge with continuity of
rehabilitation at home based on task-specific activities, during a 3-
to 4-month period with a team that included physical, occupational, and
speech therapists.9 10
We conducted a population-based, randomized controlled trial to
determine whether the home rehabilitation model as developed at the
Department of Neurology was more effective and/or resource efficient
than current, organizationally diverse rehabilitation in a hospital or
day care or through outpatient care. In this article, methodological
aspects and patient outcome at 3 months, together with patient
satisfaction and initial hospitalization and use of home rehabilitation
services, are reported.
Eligible patients with first as well as recurrent stroke were screened
for inclusion in the study and had their baseline assessment performed
5 to 7 days after stroke onset. Inclusion/exclusion criteria used are
shown in Table 1
Randomization
Rehabilitation at Home
The intervention strategy was based on prior
experience.9 The home rehabilitation program
emphasized a task- and context-oriented approach, which implies that
the patient performs guided, supervised, or self-directed activities in
a functional and familiar context. The choice of activities was based
on patients' personal interests, and adherence to structured training
between therapy sessions was promoted. The spouse, when available, was
encouraged to be an active participant in the rehabilitation process.
Individual counseling, which focused on education, applying information
learned in practical situations, and solving problems occurring in the
home, was offered to the spouse if needed. The duration and type of
therapy were recorded in a protocol by the therapists. Patients
were asked to keep diaries between therapy sessions on time and type of
training.
Routine Rehabilitation
Follow-up
The different outcome measures17 18 19 20 21 22 23 26 27
spanned the domains of impairment, disability, handicap, and subjective
health-related quality of life. Resource use for different
health-related cost items for patients was collected by consulting the
computerized register at the Stockholm County Council for hospital
inpatient and outpatient care, rehabilitation at home, primary care,
day care, rehabilitation at home and visits to private caregivers, and
as a complementary tool, by interviewing both patients and caregivers.
The frequency of individual therapy (including home visits) and group
therapy contacts per patient during hospitalization was collected from
the patients' therapy records at the Department of Neurology and
other hospital facilities to which the patients had been referred and
by identifying visits to day care facilities and therapists in primary
care from the previously mentioned computerized register. Information
on use of home service and other help (eg, transportation service,
technical aids, installation of supporting handles and other structural
alterations to the patients' homes) was collected by interviewing the
patients and spouses.
The spouses' subjective health-related quality of
life27 was measured: time spent by spouses in
helping patients with personal and instrumental
ADL20 after discharge and at the time of
follow-up, or regular help from other family caregivers and/or other
persons were recorded.
Differences in patient satisfaction with care in the HRG and the RRG
were recorded with use of a questionnaire. The
questionnaires,10 presented at the
follow-up visit 3 months after stroke, were to be completed and
returned to the Department of Neurology at Huddinge Hospital by mail.
In addition, the patients' self-reported frequency of falls and
possible complications was studied.
Study Size and Power
Statistical Analysis
Through use of logistic regression, an attempt was made to quantify the
contribution of different factors to patient functional outcome.
Thirteen variables deemed to constitute determinants of outcome and
potential confounders and others representing outcomes (all
listed in "Results") were categorized arbitrarily from professional
experience or median values. An interim data analysis was
performed when the first 50 patients had been assessed at 3
months.13
The baseline characteristics of the HRG and RRG patients followed up 3
months after stroke onset are summarized in Table 2
Almost half of the patients were independent in personal ADL
according to the Katz index, and the average score for cognitive
function of patients able to cooperate with the Mini-Mental State
Examination was 27. The assessment of the patients revealed that most
dysfunction was in the motor capacity of the upper extremity and in
manual dexterity and least dysfunction was in motor capacity of the
lower extremity and walking; even so, mean gait velocity was reduced.
The aphasia quotient for all the dysphasic patients averaged 32,
indicating that 32% of the reference sample of aphasic patients
perform worse and 80% perform better. In the HRG, there were more
patients with better upper extremity function on the affected side, and
more had aphasia with more severe symptoms, but the differences were
not statistically significant.
Independence in ADL after discharge and outcome at 3 months for
patients in the HRG and RRG are shown in Table 3
Subjective dysfunction as assessed by SIP of HRG and RRG patients at 3
months is presented in Table 4
Shown in Table 5
Mean total time for initial hospitalization was 14 days in the HRG and
29 days in the RRG, which implies a considerable reduction (52%;
P=.0008) in duration of hospital stay. After discharge, HRG
patients received a mean of 10 home visits per patient by therapists.
Reported patient satisfaction with different dimensions of care was
66% to 98% for all patients. The only statistically significant
difference was for active participation in treatment program planning
(P=.0209), and this was in favor of the HRG.
The applicability of logistic regression as a complementary tool for
assessing the intervention effect can be questioned. First, it is
possible that considerable collinearity, the association of independent
variables, may be present: eg, coping capacity with civil
status, comorbidity with social activity,31 or
ADL capacity with motor function. Second, loss of information in the
dichotomization procedure is an important consideration.
Patient selection induced by the criteria and inefficient randomization
may have caused the uneven distribution of some confounders. For
instance, it is likely that exclusion of patients with severe
perceptual deficits and the small study size resulted in exclusion of
severe right posterior (parietal or occipital) lesions, with an ensuing
high frequency of aphasics and anterior (eg, frontal) lesions in the
HRG.
It is difficult to evaluate possible bias introduced by imbalance in
the Sense of Coherence Scale scores, which implied a higher coping
ability in the RRG. The fact that this score has been found to be
associated with health variables31 may
explain the overrepresentation in the HRG of patients with a
higher burden of cardiovascular comorbidity and more
severe lesions, and it may in part explain the higher SIP scores in the
HRG, modestly improved by the multivariate
analysis.
Compared with recurrent falls, the health status relevance of
nonrecurrent falls has been deemed low, yet the similar, albeit quite
sparse, frequency of such falls in the HRG and RRG remains as a
possible negative effect of home rehabilitation. The fact that falls
were generally infrequent can be explained by selection criteria that
excluded patients with low cognitive function, a factor associated with
falls.32
Our patient selection criteria corroborate the suggestions by
Duncan33 that early staging of patients by good
cognition, continence of bowel and bladder, and mild to moderate
hemiplegia guides expected patient outcome, as measured by moderate to
complete neurological recovery and independence in most activities. The
generalizability of our results to other stroke populations might be
affected by the selection of patients with moderate disabilities and
exclusion of those with severe perceptual deficits. The SIP profile
seen in our group was similar to that observed in the study by de Haan
et al,34 with the highest impact in the area of
Household activities, followed by Recreation and Pastime, Ambulation,
and Mobility. This may suggest that as regards the effect of
rehabilitation at home, the result could be extrapolated to other
populations.
Some functional aspects of our study sample were not studied
before stroke and have a remarkable profile, eg, besides a good
neurological recovery, as seen from the motor and walking capacity,
walking speed was slowonly 60% of patients reached the usual gait
velocity for their age.35 This may suggest that
the potential impact of concomitant cardiac
disease36 on certain outcomes was important and
that it is therefore important for rehabilitation of such
nonstroke-related aspects to be included in the program under
discussion. Similarly, aphasia rehabilitation was not addressed here
and should be.
Despite reported limitations in measuring patient
satisfaction,37 overall HRG patients were more
satisfied with care, especially with active participation in the
planning of their rehabilitation program.
Since the 3-month period after stroke encompasses the majority of the
time of the home rehabilitation program and functional recovery of
patients, it is logical to assume that patient outcome and resource
utilization results at 3 months would be crucial for the evaluation of
the total cost-benefit ratio at 12 months of the program of early
discharge with continuity rehabilitation at
home.9 10
From the results of this study, we tentatively conclude that this type
of intervention is comparatively beneficial and, taking into account
the important differences of hospital and rehabilitation services,
could be routinely implemented for selected patients in southwest
Stockholm if further experimental evaluation of the midterm effects of
the HRG does not dramatically modify differences in patient health
status or cost. The pooling of our data with those of ongoing
trials11 would allow for more accurate
estimations of the effects of home rehabilitation programs on stroke
patients.
Received September 19, 1997;
revision received December 9, 1997;
accepted December 9, 1997.
2.
Terént A, Marké L-Å, Asplund K, Norrving
B, Johnsson E, Wester P-O. Cost of stroke in Sweden. Stroke. 1994;25:23632369.[Abstract]
3.
Indredavik B, Bakke F, Solberg R, Rokseth R, Lund
Haaheim L, Holme I. Benefit of a stroke unit: a randomized controlled
trial. Stroke. 1991;22:10261031.
4.
Kalra L. The influence of stroke unit rehabilitation
on functional recovery from stroke. Stroke. 1994;25:821825.[Abstract]
5.
Wade DT, Langton Hewer R, Skilbeck C, Bainton D,
Burns-Cox C. Controlled trial of home care service for acute stroke
patients. Lancet. 1985;1:323326.[Medline]
[Order article via Infotrieve]
6.
Brocklehurst JC, Morris P, Andrews K, Richards B,
Laycock P. Social effects after stroke. Soc Sci Med.
1981;15A:3539.
7.
Gladman J, Whynes D, Lincoln N, for the Domino Study
Group. Cost comparison of domiciliary and hospital-based stroke
rehabilitation. Age Ageing. 1994;23:241245.
8.
Young J, Forster A. Day hospital and home
physiotherapy for stroke patients: a comparative cost-effectiveness
study. J R Coll Physicians Lond. 1993;27:3:252258.
9.
Widén Holmqvist L, de Pedro-Cuesta J, Holm M,
Kostulas V. Intervention design for rehabilitation at home after
stroke. A pilot feasibility study. Scand J Rehabil Med. 1995;27:4350.[Medline]
[Order article via Infotrieve]
10.
Widén Holmqvist L, de Pedro-Cuesta J,
Möller G, Holm M, Sidén Å. A pilot study of rehabilitation
at home after stroke: a health economic appraisal. Scand J
Rehabil Med. 1996;28:912.[Medline]
[Order article via Infotrieve]
11.
Rodgers H. Development of on Early Supported
Discharge Policy Following Acute Stroke: An Evaluation [final
report]. Newcastle upon Tyne, UK: University of Newcastle; 1997.
12.
de Pedro-Cuesta J, Sandström B, Holm M, Stawiarz
L, Widén Holmqvist L, Bach-y-Rita P. Stroke rehabilitation:
identification of target group and planning data. Scand J Rehabil
Med. 1993;25:107116.[Medline]
[Order article via Infotrieve]
13.
Widén Holmqvist L, de Pedro-Cuesta J, Sidén
Å. A research model for stroke services development. In: Proceedings
of WHO-Europe 3rd International Conference of Health Promoting
Hospitals; June 12, 1995; Linköping, Sweden.
14.
Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW.
The index of ADL: a standardized measure of biological and psychosocial
function. JAMA. 1963;185:914919.
15.
WHO Special Report. Stroke1989: recommendation on
stroke prevention, diagnosis, and therapy. Stroke. 1989;20:14071431.
16.
Folstein MF, Folstein SF, Mc Hugh PR. Mini-Mental
State: a practical method for grading cognitive state of patients for
clinicians. J Psychiatr Res. 1975;12:189198.[Medline]
[Order article via Infotrieve]
17.
Lindmark B, Hamrin E. Evaluation of functional
capacity after stroke as a basis for active intervention:
presentation of a modified chart of motor capacity
assessment and reliability. Scand J Rehabil Med. 1988;20:103109.[Medline]
[Order article via Infotrieve]
18.
Lindmark B, Hamrin E. Evaluation of functional capacity
after stroke as a basis for active intervention: validation of a
modified chart for motor capacity assessment. Scand J Rehabil
Med. 1988;20:111115.[Medline]
[Order article via Infotrieve]
19.
Reinvang I, Engvik H. Håndbok. Norsk Grunntest
for Afasi. Oslo, Norway: Universitetsförlaget;
1980.
20.
Hulter Åsberg K, Sonn U. The cumulative structure of
personal and instrumental ADL. Scand J Rehabil Med. 1989;21:171177.[Medline]
[Order article via Infotrieve]
21.
Wade D. Leigh-Smith J, Langton Hewer R. Social
activities after stroke: measurement and natural history using Frenchay
Activities Index. Int Rehabil Med. 1985;7:176181.[Medline]
[Order article via Infotrieve]
22.
Wade DT, Wood WA, Heller A, Maggs J, Langton Hewer R.
Walking after stroke: measurement and recovery over first 3 months.
Scand J Rehabil Med. 1987;19:2530.[Medline]
[Order article via Infotrieve]
23.
Wade DT. Nine hole peg test. In:
Measurement in Neurological Rehabilitation. Oxford, UK:
Oxford Medical Publications; 1992:171.
24.
Scandinavian Stroke Study Group. Multicenter
Trial of Hemodilution in Ischemic Stroke: background and study
protocol. Stroke. 1985;16:885890.
25.
Antonovsky A. Unraveling the Mystery of
Health. San Francisco, Calif: Jossey-Bass; 1987.
26.
Collin C, Wade DT, Davis S, Horne V. The Barthel ADL
index: a reliability study. Int Disabil Stud.. 1988;10:6163.[Medline]
[Order article via Infotrieve]
27.
Sullivan M, Ahlmen M, Archenholtz B, Svensson G.
Measuring health in rheumatic disorders by means of a Swedish version
of Sickness Impact Profile: results from a population study.
Scand J Rheumatol. 1986;15:193200.[Medline]
[Order article via Infotrieve]
28.
Sunderland A, Fletcher D, Bradley L, Tinson D, Langton
Hewer R, Wade DT. Enhanced physical therapy after stroke: a one year
follow up study. J Neurol Neurosurg Psychiatry. 1994;57:856858.
29.
Jeffery DR, Good DC. Rehabilitation of the stroke
patient. Curr Opin Neurol. 1995:8:6268.
30.
Ottenbacher KJ, Janell S. The result of clinical trials
in stroke rehabilitation research. Arch Neurol. 1993;50:3744.
31.
Winqvist M. "Att simma i förgiftat vatten."
Om hälsa och ohälsa bland de allra äldsta. Stockholm,
Sweden. Rapporter/Stiftelsen Stockholms läns äldrecentrum;
1995.
32.
Nyberg L, Gustavsson Y. Patient falls in stroke
rehabilitation: a challenge to rehabilitation strategies.
Stroke. 1995;26:838842.
33.
Duncan P. Stroke disability. Phys Ther. 1994;74:399407.
34.
de Haan RJ, Limburg M, van der Meulen JHP, Jacobs HM,
Aaronson NK. Quality of life after stroke: impact of stroke type and
lesion location. Stroke. 1995;26:402408.
35.
Aniansson A, Rundgren A, Sperling L. Evaluation of
functional capacity in activities of daily living in 70-year-old men
and women. Scand J Rehabil Med. 1980;12:145154.[Medline]
[Order article via Infotrieve]
36.
Roth EJ. Heart disease in patients with stroke,
part II: impact and implications for rehabilitation. Arch Phys
Med Rehabil. 1994;75:94101.[Medline]
[Order article via Infotrieve]
37.
Larsson G, Wilde B. Är patienten nöjd?
Läkartidningen.. 1995;92:15871590.[Medline]
[Order article via Infotrieve]
© 1998 American Heart Association, Inc.
Original Contributions
A Randomized Controlled Trial of Rehabilitation at Home After Stroke in Southwest Stockholm
![]()
Abstract
Top
Abstract
Introduction
Subjects and Methods
Results
Discussion
References
Background and PurposeThis
study describes the methodology, patient outcome, and use of hospital
and rehabilitation services at 3 months of a population-based
randomized controlled trial. The purpose was to evaluate rehabilitation
at home after early supported discharge from the Department of
Neurology, Huddinge Hospital, for moderately disabled stroke patients
in southwest Stockholm.
Key Words: clinical trials stroke management stroke outcome stroke rehabilitation
![]()
Introduction
Top
Abstract
Introduction
Subjects and Methods
Results
Discussion
References
In Sweden, because
95% of patients with acute stroke are admitted to a
hospital,1 most of the initial rehabilitation is
centered around a time spent in the hospital. The cost of hospital and
outpatient care and social service accounts for 76% of the overall
Swedish stroke cost.2 There is a rapidly growing
body of data from randomized controlled trials on the effect of various
aspects of stroke prevention and management. Although in recent years
there has been an increasing emphasis on the importance of
organizational aspects of stroke rehabilitation, as yet few cost
analyses have been run with regard to gains in stroke
rehabilitation.2
![]()
Subjects and Methods
Top
Abstract
Introduction
Subjects and Methods
Results
Discussion
References
Patient Selection and Baseline Assessment
A graph (depicted in Fig 1
) of the
flow chart and caring chain for patients hospitalized at the Department
of Neurology with a diagnosis of transient ischemic attack or
stroke over a 1-year period was drawn up on the basis of data from our
previous studies in southwest Stockholm.13 The
patients in this study were recruited during the period from September
1993 through March 1996, from the group of patients who, according to
the Katz ADL index (grades A-E),14 were continent
and independent in feeding 1 week after a first or recurrent acute
stroke and had an expected average hospitalization time of 4 weeks in
routine care.9 During the study period, residents
in the Huddinge Hospital catchment area with suspected transient
ischemic attack or acute stroke were admitted to the Emergency
Department at Huddinge Hospital and, in general, transferred that same
day or the following day to the stroke unit at the Department of
Neurology. In cases where the stroke unit was filled to capacity,
patients were admitted to two adjacent neurological wards. Diagnosis of
stroke was based on the medical history and clinical examination of the
patient and defined according to World Health Organization
criteria.15 All patients routinely underwent a CT
scan.

View larger version (25K):
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Figure 1. Flow chart and caring chain of patients hospitalized at the
Huddinge Hospital Department of Neurology with a diagnosis of transient
ischemic attack (TIA) or stroke during a 1-year period. ADL
indicates activities of daily living.
. Regarding baseline
assessment, the research physical therapist administered the
Mini-Mental State Examination16 and assessed the
motor capacity.17 18 Patients with clinical signs
of dysphasia were evaluated19 by the research
therapist on the basis of how they performed in comparison with a
reference sample of aphasia patients. The speech therapist also
estimated whether mental functions were within normal limits for the
dysphasic patients who were unable to perform the examination.
Information regarding demographic characteristics, independence in
personal and instrumental ADL,20 and frequency of
activities21 before stroke were obtained by
interviewing the patients. Medical history, investigations performed,
and clinical diagnoses were identified from patients' medical
records at the Department of Neurology. Walking
capacity22 and manual
dexterity23 were tested by the research physical
therapist. Neurological function24 was rated by
the senior neurologist responsible for the patient in question. Coping
capacities of the patients and their spouses were tested with use of
the shortened version of the Sense of Coherence
Scale25 at 6 and 12 months after stroke. Before
randomization, the patients were managed in the wards according to
existing practice. The trial was approved by the Huddinge Hospital
Ethical Committee.
View this table:
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Table 1. Entry Criteria for the Patients to the Study
Immediately after informed consent was obtained, the patients
were randomized 1:1, either to the HRG or to the RRG blocks of two or
four individuals, by a computerized random procedure and sealed
numbered envelopes. The same person (J.P.C.) designed and carried the
randomization procedure, which remained unknown by the evaluators until
the last patient at 1-year follow-up was examined.
Two physical therapists, two occupational therapists, and one
speech therapist associated with the stroke unit formed the team of the
home rehabilitation outreach service. A social worker was attached to
the team on a consulting basis. One of the therapists was assigned as a
case manager for the patient, which implied that she coped with a wider
domain of function than is currently in vogue and that she constituted
the link between hospital and outpatient care. In each case, the case
manager was responsible for coordination of the discharge procedure,
most of the at-home therapy, coordination between therapists in the
home rehabilitation team, and contact with the neurologist responsible.
A program approximately 3 to 4 months in duration was tailored for each
patient. The frequency of therapy contacts for the patients receiving
rehabilitation at home was decided by the providing therapist in
consultation with the patient and his or her family. The frequency of
home visits was gradually reduced until the therapist discharged the
patient. Two half-hour meetings per week were scheduled for
coordination purposes by the home rehabilitation team. If continued
rehabilitation was required after such a period, the patient was
referred to routine outpatient rehabilitation.
The control group consisted of the stroke patients who received
routine rehabilitation service. All patients in this group were also
admitted to the Department of Neurology. If required (and after
evaluation by specialists from geriatric or rehabilitation clinics) the
patients were transferred for continued inpatient rehabilitation and/or
day care. In this context, routine rehabilitation denotes a
heterogeneous set of interventions ranging from the best
established in the hospital, day care, and/or outpatient care, to
others introduced during the study period, such as daily afferent
sensory stimulation by low-frequency transcutaneous electrical nerve
stimulation and home-based rehabilitation initiated by the Department
of Geriatrics.
Follow-up visits were scheduled at 3, 6, and 12 months after
stroke. All the patients and the spouses were interviewed and/or
evaluated at home by an external assessor, a research physical
therapist (L. von K.). In addition, the patients with dysphasia were
assessed by a research speech therapist (K.J.). The assessors were
blinded with respect to group assignment and were not involved with
randomization or organization of treatment, nor did they have contact
with any of the participating rehabilitation staff during patient
treatment periods. The same assessor conducted all subsequent
assessments. The feasibility of administering all the tests except the
aphasia test in a single home visit was verified in the pilot
study.9 10
The power requirements for demonstrating differences in cost
were considerably lower than those for showing statistically
significant differences in effect. We concluded that a study size of
130 patients would allow for indication of possible moderate positive
effects and demonstrate important differences in secondary effects
(odds ratio of >3), as well as savings of a magnitude that could
motivate changes in health care policy and so yield an acceptable
balance of results. Because of financial and manpower restrictions, for
speech therapists in particular, we were able to include only 83
patients, yielding a lower proportion of aphasics than expected.
Statistical significance for intergroup differences in outcome
was assessed by the Fisher exact test,
2 test,
and Mann-Whitney test.
![]()
Results
Top
Abstract
Introduction
Subjects and Methods
Results
Discussion
References
In total, 220 patients were screened for inclusion. Eighty-six
patients fulfilled the inclusion criteria; of those, 83 gave their
informed consent for participation. Since 1 patient in the HRG withdrew
for personal reasons the day after discharge from the hospital and
another in the RRG was diagnosed with a hepatic carcinoma after
inclusion in the study and died 2 months after his acute stroke, the
final number of patients recruited to the HRG and RRG and followed up 3
months after stroke totaled 41 and 40, respectively.
. The socioeconomic situation of the
patients in the HRG and the RRG were very similar. Mean age was 72
years, 54% were male, and almost one third of the patients lived
alone. The great majority of patients were born in Sweden, had only a
basic education, and were retired by the time of stroke onset. Most of
the patients were already restricted in their activities before stroke.
Almost one fourth were dependent in ADL, and the average level of
frequency of activities reached 62%. The health status of the majority
of the patients was affected before stroke: according to medical
records, the mean number of associated diseases per patient was
1.8. Uneven distributions by several patient characteristics were
found. HRG patients had a 10% lower coping capacity; a higher
frequency of associated diseases (P=.0535), especially
transient ischemic attack and diabetes; and higher frequencies
of abnormal CT scan results on admission and left hemisphere
lesions.
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Table 2. Baseline Characteristics of Patients in the HRG and
RRG
. One patient in the RRG was still
hospitalized at 3 months after stroke. After discharge from the
hospital, most patients were still dependent in instrumental ADL, to an
even higher degree in the HRG than the RRG. At 3 months, the patients
generally showed moderate to almost complete recovery vis-à-vis
personal ADL, total motor capacity, manual dexterity, walking, and
linguistic ability; however, independence in higher ADL functions was
attained by only 35% of the group, and gait velocity remained lower.
With regard to frequency of activities, there was an 18% decrease
compared with the situation before stroke. In general and save for the
aphasia score, better outcomes were found in the HRG in the
above-mentioned measures, but differences between the groups were not
statistically significant. Thirty-one per cent of the patients reported
first or recurrent falls. An almost twofold higher, statistically
nonsignificant frequency of nonrecurrent falls was observed in the HRG.
In the case of 2 patients in the RRG, the falls resulted in
fractures.
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Table 3. Outcome of Patients in the HRG and the RRG at 3
Months
.
The median score of total SIP (range, 0 to 100) for all patients in the
study was 16.0, with greater disability observed in physical than in
psychosocial functioning. Patients reported particularly high levels of
dysfunction in Household Management, followed by Recreation and Pastime
and Ambulation. No significant differences in subjective dysfunction
were found between the HRG and RRG patients, except for Communication
and Emotional Behavior, where those in the HRG perceived significantly
more dysfunction.
View this table:
[in a new window]
Table 4. Median, and Range Scores for Subjective Dysfunction
As Assessed by SIP in Patients in the HRG and the RRG at 3 Months
are the comparative
effects of rehabilitation at home as seen for different patient outcome
variables from the crude and multivariate
analyses. Although no statistically significant effects of home
rehabilitation were found, a pattern of associations was seen in both
analyses: (1) for patient outcomes tested by the therapist for
total motor capacity, manual dexterity, and walking, a systematic,
positive, modest effect (from a mean OR of 1.76 in crude to a mean OR
of 1.12 in multivariate analysis) was seen; (2)
in patient-reported outcomes for frequency of lifestyle activities and
ADL, a systematic, positive, modest effect (from a mean OR of 1.28 in
crude to a mean OR of 1.70 in multivariate
analysis) was also observed; and (3) for SIP Total and selected
SIP Communication and SIP Emotional Behavior, systematic negative
effects (ranging from an OR of 0.45 to an OR of 0.84) were seen.
View this table:
[in a new window]
Table 5. Comparative Effects of Rehabilitation at Home and
Other Factors for Different Patients Outcome from Logistic Regression
Analysis
![]()
Discussion
Top
Abstract
Introduction
Subjects and Methods
Results
Discussion
References
This study focuses on moderately disabled stroke patients
who, in line with prior experience, are those who might benefit most
from specific interventions.28 29 Difficulties
inherent in the use of randomized controlled techniques to evaluate
poststroke rehabilitation, such as sample size and/or
blindness,30 may have limited the validity of the
result of this study. Nevertheless, the study demonstrated that early
supported discharge following acute stroke, with continuity of
rehabilitation at home by a team associated with the Department of
Neurology, implied a considerable reduction in bed-days and showed that
early supported discharge with continuity of rehabilitation at home of
moderately disabled stroke patients in southwest Stockholm did not
account for large differences in patient outcome, as seen from tested
functions of total motor capacity, manual dexterity, and walking, or
self-reported independence in ADL, frequency of activities, and
health-related quality of life. Minor differences suggested that higher
effectiveness in the HRG versus the RRG might be present for total
motor capacity, manual dexterity, walking, and independence in ADL as
well as in frequency of activities. The suggested negative comparative
impact of the home rehabilitation program on SIP Total, and
particularly on SIP Communication and SIP Emotion, are more difficult
to interpret. The small difference in SIP Total scores between the HRG
and RRG, which translated as a considerable difference on
categorization in the logistic regression analysis, may thereby
have been artifact generated and negligible, since most patients
aggregated around the cut-off value.
![]()
Selected Abbreviations and Acronyms
ADL
=
activities of daily living
HRG
=
home rehabilitation group
OR
=
odds ratio
RRG
=
routine rehabilitation group
SIP
=
Sickness Impact Profile
![]()
Acknowledgments
This study was supported by the Swedish Medical Research
Council (K9127Ä-0976402); by grants from The Swedish Society
for Multiple Sclerosis (NHR), 1987-Foundation for Stroke Research, The
Swedish Stroke Association, Clas Groschinsky's Foundation, National
Board of Health and Welfare, and Foundation Solstickan; and by funds
from the Karolinska Institute and the Carlos III Institute of Health in
Madrid. We should like to thank Paul Bach-y-Rita, Department of
Rehabilitation Medicine, University of Wisconsin-Madison Medical
School, for his contribution in developing the stroke rehabilitation
project in Southwest Stockholm County; A. Fyrby (Department of
Physical Therapy), M. Linde (Department of Occupational Therapy), and
I. Öhlund (Department of Geriatric Medicine) for training the
patients at home; P. Diener, B. Höjeberg, and licensed and
practical nurses (Department of Neurology, Huddinge Hospital) for
assistance in recruitment and baseline evaluation of the
patients; and K. Jansson-Halme for home evaluation of patients and
spouses at 3 months.
![]()
References
Top
Abstract
Introduction
Subjects and Methods
Results
Discussion
References
1.
Stegmayr B, Asplund K. Measuring Stroke in
the population: quality of routine statistics in comparison with a
population-based stroke registry. Neuroepidemiology. 1992;11:204213.[Medline]
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