(Stroke. 2000;31:1509.)
© 2000 American Heart Association, Inc.
Original Contributions |
Memory Impairment in Out-of-Hospital Cardiac Arrest Survivors Is Associated With Global Reduction in Brain Volume, Not Focal Hippocampal Injury
From Cardiovascular Research (N.R.G., K.A.A.F.), University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK; the Psychology Department (K.S.), University of Stirling, Stirling, UK; the Department of Medical and Radiological Sciences (J.B., A.B.) and the Department of Psychiatry (K.P.E., M.F.G.), University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK; and the School of Psychology (R.E.O.), University of St Andrews, St Andrews, Fife, UK.
Correspondence to Dr Neil R Grubb, MRCP, Cardiovascular Research, University of Edinburgh, Royal Infirmary of Edinburgh, 1 Lauriston Pl, Edinburgh, EH3 9YW, UK. E-mail N.Grubb{at}ed.ac.uk
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Abstract |
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Background and Purpose—More than 30% of out-of-hospital cardiac arrest (OHCA) survivors suffer significant memory impairment. The hippocampus may be vulnerable to hypoxic injury during cardiac arrest. The purpose of this study was to determine whether selective hippocampal injury is the substrate for this memory impairment.
Methods—Seventeen OHCA survivors and 12 patients with uncomplicated myocardial infarction were studied. OHCA survivors were divided into those with impaired and intact memory. Memory was assessed by use of the Rivermead Behavioural Memory Test and Doors and People Test. MRI was used to determine intracranial, whole-brain, amygdala-hippocampal complex, and temporal lobe volumes. Brain structure was also examined by statistical parametric mapping.
Results—Left amygdala-hippocampal volume was reduced in memory-impaired OHCA victims compared with control subjects (mean 3.93 cm3 and 95% CI 3.50 to 4.36 cm3 versus mean 4.65 cm3 and 95% CI 4.37 to 4.93 cm3; P=0.002). Left temporal lobe and whole-brain volumes were also reduced. There were no differences in amygdala-hippocampal volume indexed against ipsilateral temporal lobe volume. Significant correlations were observed between total brain volume and Rivermead Behavioural Memory Test (r=0.56, P<0.05) and Doors and People Test (r=0.67, P<0.01) scores in OHCA survivors. Both recall and recognition were compromised in memory-impaired subjects. Statistical parametric mapping did not detect focal brain abnormalities in these subjects. Global cerebral atrophy was confirmed by qualitative assessment.
Conclusions—Memory impairment in OHCA survivors is associated with global cerebral atrophy, not selective hippocampal damage. Rehabilitation protocols need to account for the global nature of the brain injury.
Key Words: atrophy • heart arrest • magnetic resonance imaging • memory
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Introduction |
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TopAbstractIntroductionSubjects and MethodsResultsDiscussionReferences |
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As a result of the defibrillation initiatives of the emergency medical services and increased public awareness of cardiopulmonary resuscitation techniques, there has been a substantial increase in the number of individuals surviving out-of-hospital cardiac arrest (OHCA) in many urban areas.1 2 3 In Edinburgh, Scotland, a 4-fold increase in the rate of survival to discharge was reported after the introduction of semiautomated ambulance defibrillators.4 Although these and other centers have achieved impressive improvements in mortality figures, comparatively little attention has been focused on the sequelae of the cardiac arrest itself. Neuropsychological deficits can result from cerebral hypoxia during cardiac arrest and have the potential to interfere with recovery and to affect the patients’ daily functioning after discharge home. Despite this, only a small number of studies have systematically examined cognitive function in OHCA survivors. Clinically important cognitive impairment has been reported for 20% to 50% of the cases.5 6 7
In a previous study, our group investigated the prevalence of chronic memory impairment among OHCA survivors. Moderate or severe impairment, assessed by the Rivermead Behavioural Memory Test (RBMT), was noted in almost 40% of the individuals assessed 6 months after cardiac arrest.7 These deficits were not present in comparable subjects with previous myocardial infarction (MI) who had not had a cardiac arrest. Examination of the individual subtests in that study indicated that recall function was impaired and that recognition function was preserved in cardiac arrest survivors. This pattern of cognitive impairment has been previously observed in individuals with memory impairment associated with localized hippocampal damage, including patients with the classic amnestic syndrome.8 The CA1 field of the hippocampus is especially vulnerable to hypoxic damage. This zone is rich in N-methyl-D-aspartate receptors, which have been implicated in the mechanism of hippocampal cell death during hypoxia through the glutamate-mediated entry of calcium into hippocampal cells.9 Studies in primates and in rats have shown that hypoxia causes specific CA1 field hippocampal damage, leading to anterograde amnesia.10 Amnesia after human cardiac arrest has also been reported to be associated with specific degeneration of hippocampal CA1 neurons.11 12 Although it is likely that hypoxia during cardiac arrest results in a generalized brain insult, it is possible that the hippocampus could be selectively damaged.13 14 If so, N-methyl-D-aspartate receptor antagonism could form a target for neuroprotective treatment during prolonged cardiac arrest.9
High-resolution MRI can be used to measure absolute hippocampal volume relative to the volumes of other brain structures. A specific reduction in hippocampal volume has previously been demonstrated in patients with the amnestic syndrome, but this has not been specifically examined in cardiac arrest survivors.15 Although cerebral atrophy has previously been reported in a population of cardiac arrest survivors, regional indices of brain volume and cognitive indices were not measured.16 The present study addressed the hypothesis that selective hippocampal injury is the neuroanatomic substrate of memory impairment in OHCA survivors. Two key methods were used to test this hypothesis: (1) examination of brain structure by use of MRI and (2) further examination of recall and recognition memory function by use of a purpose-designed neuropsychological test.17
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Subjects and Methods |
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TopAbstractIntroductionSubjects and MethodsResultsDiscussionReferences |
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We attempted to contact all adult OHCA survivors, with a presumed cardiac etiology for their arrest, who had been successfully discharged from the Royal Infirmary of Edinburgh between July 1997 and November 1998. Control subjects were enrolled from contemporaneous patients who had survived acute MI and who had not suffered a cardiac arrest. Approval for the present study was granted by the Lothian Research Ethics Committee (Medicine and Oncology subcommittee) and the Royal Infirmary of Edinburgh NHS Trust. General exclusion criteria were as follows: major preexisting psychiatric illness, use of psychotropic drugs, previous cardiac arrest, previously diagnosed organic brain disease or stroke, geographic remoteness (residence outside Lothian region). Exclusion criteria for MRI examinations included the following: cardiac pacemakers and automatic implantable cardioverter-defibrillators, metallic prosthetic heart valves, cochlear implants, aneurysm clips, and intraocular foreign bodies. We noted the use of ß-adrenoceptor antagonists, which could potentially affect performance in cognitive tests,18 and angiotensin-converting enzyme inhibitors.
On the basis of the results of a previous study in this patient
population, we expected that 
40% of OHCA victims would have
clinically significant memory impairment. By prespecified
analysis, this group was subdivided into subjects with intact
and with impaired memory function. Impaired memory function was defined
as a score 
1 SD below the age-scaled mean total score of the Doors
and People Test (DPT; see below). This allowed comparison of MRI
indices in memory-impaired cardiac arrest survivors with those of both
memory-preserved cardiac arrest survivors and the main control
group.
Assessment of Cognitive Function
Cognitive testing was performed in a single 1-hour session by a
trained graduate psychologist, who was blinded to the patient’s
medical history. Premorbid intellectual function was estimated by using
the revised version of the National Adult Reading Test
(NART).19 This test is relatively ineffectual in patients
with dementia and has been previously used as an index of premorbid
intellectual function.20 Memory function was assessed by
the use of 2 tests. The RBMT examines episodic long-term memory (the
ability to abstract information from short-term memory to true
long-term memory) and consists of 12 subtests designed to identify
memory deficits that might be encountered during daily
living.21 These include the following: remembering a name,
an appointment, the location of a hidden item, objects and faces from
picture cards, a short route, and a news story. In addition,
orientation is also tested. This test allocates a score of 0 to 2
points for each subtest, giving a maximum total score 24 points. Recall
and recognition memory function were assessed by the recently developed
DPT.17 This test provides separate indices of recall,
recognition, and verbal and visual memory that are matched for
difficulty. The test spans a wide range of abilities, avoiding problems
of "floor" and "ceiling" effects.
MRI Scans and Analysis
MRI scans were performed by using a 1-T SPE Magnetom scanner
(Siemens) after, but on the same day as, memory testing. After midline
localization, 3 scan sequences were used for whole-brain imaging. The
first was a double spin-echo sequence, giving simultaneous
proton-density and T2-weighted images (relaxation time 3565 ms,
excitation time 20 and 90 ms, 31 contiguous 5-mm slices acquired in the
Talairach Plane, field of view 250 mm). These data were
used to calculate intracranial and cerebrospinal fluid (CSF) volumes
with the use of ANALYZE (Mayo Foundation). A threshold was set on the
slice above the lateral ventricles to remove extracranial tissues.
Other areas were edited manually. Total intracranial volume was summed
by use of ANALYZE. The CSF was measured by drawing from around the
lateral ventricles and loading the data into the multispectral option
of ANALYZE, and the volumes calculated by using the unsupervised
"chain" method. The second scan sequence, for the regional
volumetric analysis and whole-brain volume, was a 3D
magnetization–prepared, rapid-acquisition, gradient echo sequence
consisting of an 180° inversion pulse followed by a fast low-angle
shot collection (flip angle 12°, relaxation time 10 ms, excitation
time 4 ms, inversion time 200 ms, relaxation time delay time 500
ms, and field of view 250 mm), giving 128 contiguous 1.88-mm-thick
slices in the coronal plane orthogonal to the Talairach plane.
Inhomogeneity corrections were performed on the images by using flood
phantom data. Image analysis was performed on Sun Microsystem
workstations with the use of ANALYZE by a single radiographer
performing intrarater studies at intervals during analysis to
ensure consistency of technique. Whole-brain volume was
measured by using manually assisted automatic editing that used a
threshold calculated by taking the mean of 2 regions of gray matter and
2 regions of CSF. The temporal lobe and amygdala-hippocampal complexes
were identified, the areas were outlined, and volumes were calculated
by summing voxels in the regions of interest.22 A third
fluid-attenuated inversion recovery (FLAIR) scan sequence was used to
detect lesions in the central white matter and lesions next to CSF in
the cortex and periventricular regions.23
MRI data were also spatially transformed into stereotactic space, segmented, and analyzed voxel by voxel to identify any differences in gray matter density.24 Statistical parametric mapping (SPM) was used to identify overall differences in gray matter density between groups.25 SPM uses a computerized transformation algorithm to create an "average brain image" for each group under study, allowing voxel-by-voxel analysis of regional differences in gray matter signal. This provides an additional method of identifying regions of the brain in which consistent structural differences occur between groups.
MRI scans were also examined qualitatively by an experienced radiologist, who was blinded to the subjects’ medical histories. This allowed identification of the frequency of specific abnormalities such as leukoaraiosis and discrete cerebral infarct zones. Cerebral atrophy was assessed on the basis of ventricular size and sulcal width from the proton density–weighted sequence. High-intensity signal was assessed from the T2-weighted and FLAIR sequences. The extent and density of leukoaraiosis was assessed from the FLAIR sequence. Lacunae, central white matter, and basal ganglia were assessed on T1-weighted images. Cortical infarcts were assessed on all sequences.
Statistical Analysis
A 3-group analysis comparing baseline variables
(age, sex, and estimated premorbid intelligence) of the control group
and of the memory-impaired and memory-preserved cardiac arrest groups
was performed. Intergroup differences in sex ratio were tested by use
of the 
2 statistic. Times from index event to
assessment were compared by the Mann-Whitney test. Variables for
which significant intergroup differences existed were entered as
covariates in the analysis of MRI volumetric
parameters with the use of ANCOVA. For intergroup
comparisons of amygdala-hippocampal volumes, these variables were
expressed as absolute values and also as a proportion of whole-brain
and ipsilateral temporal lobe volumes. Intergroup comparisons of brain
volume indices were examined by ANCOVA. Potential associations between
brain volume indices and memory test scores were analyzed by
the Pearson correlation coefficient.
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Results |
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TopAbstractIntroductionSubjects and MethodsResultsDiscussionReferences |
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General Characteristics
For general characteristics of cardiac arrest and control subjects, see Table 1
. There were
no significant intergroup differences in age, sex, or use of
ß-adrenoceptor antagonists or
angiotensin-converting enzyme
inhibitors. A significant intergroup difference was
found for NART-estimated premorbid intelligence scores. Post hoc
analysis (Scheffé test) showed that this difference was
significant between MI controls and memory-intact OHCA subjects
(P<0.05). In subsequent analyses of memory and MRI
data, the NART-derived IQ score was entered as a covariate.
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Memory Function
Intergroup comparisons of memory test scores are shown in Table 2. Collectively, patients in the cardiac
arrest groups achieved lower total scores than did controls in the DPT,
which was subsequently used to identify memory-impaired subjects (mean
7.4 points and 95% CI 5.2 to 9.6 points versus mean 11.6 points and
95% CI 9.4 to 13.7 points; P=0.015). The DPT age-scaled
score was used to define the memory-impaired OHCA group; this group
exhibited marked impairment of all subtest indices compared with
control and memory-intact OHCA subjects. The criterion used to define
this group also identified subjects with significant deficits measured
by the RBMT. Significantly, both recall and recognition memory function
were impaired in this group, in contrast with earlier results with use
of the RBMT. There were no significant differences in any of the memory
indices between the MI control and memory-intact OHCA groups.
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Anatomic Data
Results of regional and total brain volume analyses are
shown in Table 3. There were no
intergroup differences in intracranial volume. Several intergroup
differences were identified in brain volume parameters.
Memory-impaired OHCA subjects had smaller left temporal lobe and left
amygdala-hippocampal complex volumes than did control subjects.
Memory-impaired OHCA subjects also had smaller total brain volume and
left and right temporal lobe volumes than did memory-preserved OHCA
subjects. Memory-impaired OHCA subjects also had significantly
increased lateral ventricle volume than did either memory-preserved
OHCA subjects or control subjects.
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When amygdala-hippocampal volumes were expressed relative to
whole-brain and ipsilateral temporal lobe volumes, no significant
differences were found between memory-impaired cardiac arrest subjects
and the other 2 groups. Results of correlation analysis of
MRI-derived volume indices and summary memory test scores for the
combined cardiac arrest groups are shown in Table 4. Moderate correlations were found
between RBMT and DPT test scores and total brain, left temporal, and
right amygdala-hippocampal volumes. SPM analysis did not show
any significant focal intergroup differences in brain structure. The
qualitative ratings of the MRI scans are summarized in Table 5. The memory-impaired OHCA group was
rated as having the greatest degree of atrophy, high-intensity signal,
and leukoaraiosis. Representative MRI scans of
memory-impaired and memory-intact OHCA patients are shown in the
Figure.
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Discussion |
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TopAbstractIntroductionSubjects and MethodsResultsDiscussionReferences |
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In the present study, we tested the hypothesis that the anatomic substrate for chronic memory impairment occurring after OHCA is selective hippocampal damage. This hypothesis was based on the known susceptibility of the hippocampus to hypoxic injury, possibly mediated by the N-methyl-D-aspartate receptor–dependent entry of calcium into CA1 field hippocampal neurons. The hypothesis was neither supported by the results of MRI scanning nor by more detailed testing of recall and recognition memory function.
Compared with control subjects who had not had a cardiac arrest, memory-impaired OHCA survivors did have significantly reduced left amygdala-hippocampal volume. However, reference left temporal lobe and total brain volumes were similarly reduced. Furthermore, total brain volume was significantly reduced in memory-impaired compared with memory-preserved OHCA subjects, and significant correlations were found between memory test scores and total brain volume but not left amygdala-hippocampal volume. Taken together, these findings suggest that global brain atrophy rather than selective hippocampal damage is responsible for the deficits seen in the memory-impaired subjects. The finding of a global brain injury, derived from volumetric analysis, is also confirmed by the failure of SPM analysis to identify a regional difference in brain volume when the 3 groups were compared. The groups were too small to draw conclusions on the time course of development of cerebral atrophy.
The prevalence and severity of memory impairment was similar to that observed in our previous study, which used the RBMT.7 The mean memory index scores in the memory-impaired OHCA group indicate that these individuals have severe memory impairment that is sufficient to compromise everyday activities. In the present study, the DPT was also used to obtain additional information about recall and recognition memory. Overall, cardiac arrest survivors had significantly reduced recall and recognition memory function compared with function in control subjects. This also suggests a global cerebral insult rather than specific hippocampal substrate for the observed memory impairment. However, it is not universally agreed that hippocampal injury affects recall memory in isolation while preserving recognition memory.8 26 27
The results of the structural and functional studies suggest that in patients who suffer from memory impairment after cardiac arrest, hypoxic injury results in generalized cerebral atrophy. In cognitive neuroscience, survivors of cardiac arrest have previously been used as models of selective hippocampal damage, on the assumption that hypoxic insult was confined to the hippocampal complex neurons.11 12 The results of the present study do not support that premise and imply that aspects of cognitive function other than memory are also likely to be affected by cardiac arrest. Markowitsch et al28 recently examined brain function in cardiac arrest victims by using positron emission tomography and concluded that these patients may not be valid models for pure hippocampal or even medial temporal lobe pathology because they suffer much more widespread brain damage.
Practical Implications of the Present Study
Memory impairment is common among OHCA survivors. From the
present study, it is clear that both recall and recognition memory
function are significantly impaired in these individuals. Although
hippocampal injury may account for some of these patients’ memory
deficits, it is only one component of a more widespread, global,
hypoxic cerebral insult. From this, it is likely that other aspects of
cognitive function will also be compromised and that further studies of
cognition in cardiac arrest survivors are now warranted. It is of note
that Wilson,13 in a study of 18 patients who had suffered
cerebral hypoxia, including 4 who suffered hypoxia
during cardiac arrest, reported widespread cognitive impairment
affecting memory, visuospatial, and executive function. Before a
comprehensive rehabilitation strategy can be devised for this growing
population of patients, it will be important to characterize these and
other aspects of cognitive function more fully. Behavioral strategies
that are used in patients with the classic amnestic syndrome, a
condition usually associated with isolated hippocampal pathology, are
unlikely to alleviate all of the neuropsychological deficits from which
OHCA survivors suffer.29 However, novel cognitive
strategies, such as errorless learning, which eliminates
trial-and-error approaches to learning, have proved useful in other
groups of memory-impaired patients and will be the subject of further
evaluation.30 Further evaluation of cognitive deficits is
required to provide the platform on which to base a cognitive
rehabilitation program.
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Acknowledgments |
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This work was supported by a project grant provided by the British Heart Foundation. The authors thank the subjects who participated in this study and Norma Brearley for the careful preparation of the manuscript.
Received November 2, 1999; revision received March 23, 2000; accepted March 23, 2000.
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References |
|---|
|
TopAbstractIntroductionSubjects and MethodsResultsDiscussionReferences |
|---|
1. de Vreede-Swagemakers JJ, Gorgels APM, Dubois-Arbuow WI, van Ree JW, Daeman M, Houben LG, Wellens HJ. Out-of-hospital cardiac arrest in the 1990s: a population-based study in the Maastricht area on incidence, characteristics and survival. J Am Coll Cardiol. 1997;30:1500–1505.[Abstract]
2. Gaul GB, Gruska M, Titscher G, Blazek G, Havelec L, Marktl W, Muellner W, Kaff A. Prediction of survival after out-of-hospital cardiac arrest: results of a community-based study in Vienna. Resuscitation. 1996;32:169–176.[Medline] [Order article via Infotrieve]
3.
Kuisma M, Määttä T. Out-of-hospital
cardiac arrests in Helsinki: Utstein style reporting. Heart. 1996;76:18–23.
4. Hamer DW, Gordon MWG, Cusack S, Robertson CE. Survival from cardiac arrest in an accident and emergency department: the impact of out-of-hospital advisory defibrillation. Resuscitation. 1993;26:31–36.[Medline] [Order article via Infotrieve]
5. Beuret P, Feihl F, Vogt P, Perret A, Romand JA, Perret C. Cardiac arrest: prognostic factors and outcome at one year. Resuscitation. 1993;25:171–179.[Medline] [Order article via Infotrieve]
6.
Earnest MP, Yarnell PR, Merrill SL, Knapp GL.
Long-term survival and neurologic status after resuscitation from
out-of-hospital cardiac arrest. Neurology. 1980;30:1298–1302.
7.
Grubb NR, O’Carroll R, Cobbe SM, Sirel J, Fox KAA.
Chronic memory impairment after cardiac arrest outside hospital.
Br Med J. 1996;313:143–146.
8. Aggleton JP, Shaw C. Amnesia and recognition memory: a re-analysis of psychometric data. Neuropsychologia. 1996;34:51–62.[Medline] [Order article via Infotrieve]
9. Rothman SM, Olney JW. Excitotoxicity and the NMDA receptor. Trends Neurosci. 1987;10:299–302.
10. Auer RN, Jensen ML, Whishaw IQ. Neurobehavioral deficit due to ischaemic brain damage limited to half of the CA1 section of the hippocampus. J Neurosci. 1989;9:1641–1647.[Abstract]
11. Victor M, Agamanolis J. Amnesia due to lesions confined to the hippocampus: a clinical-pathological study. J Cogn Neurosci. 1990;2:246–257.
12. Zola-Morgan S, Squire LR, Amaral DG. Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. J Neurosci. 1986;6:2950–2967.[Abstract]
13. Wilson BA. Cognitive functioning of adult survivors of cerebral hypoxia. Brain Inj. 1996;10:863–874.[Medline] [Order article via Infotrieve]
14. Parkin AJ, Miller J, Vincent R. Multiple neuropsychological deficits due to anoxic encephalopathy: a case study. Cortex. 1987;23:655–665.[Medline] [Order article via Infotrieve]
15. Squire LR, Amaral DG, Press GA. Magnetic resonance imaging of the hippocampal formation and mammillary nuclei distinguish medial temporal lobe and diencephalic amnesia. J Neurosci. 1990;10:3106–3117.[Abstract]
16.
Roine RO, Raininko R, Erkinjuntti T, Ylikoski A, Kaste
M. Magnetic resonance imaging findings associated with cardiac arrest.
Stroke. 1993;24:1005–1014.
17. Baddeley A, Emslie H, Nimmo-Smith I. Doors and People: Test Manual. Bury St Edmunds, UK: Thames Valley Test Company; 1994.
18. Powell J, Pickering A. The effect of antihypertensive medication on learning and memory. Br J Clin Pharmacol. 1993;35:105–113.[Medline] [Order article via Infotrieve]
19. Nelson HE, O’Connell A. Dementia: the estimation of premorbid intelligence. Cortex.. 1978;14:1234–1244.
20. O’Carroll R. The assessment of premorbid ability: a critical review. Neurocase. 1995;1:83–89.
21. Wilson B, Cockburn J, Baddeley AD. Rivermead Behavioural Memory Test. Titchfield, Fareham: Thames Valley Test Company; 1985.
22. Lawrie SM, Whalley H, Kestelman JN, Abukmeil SS, Byrne M, Hodges A, Rimmington JE, Best JJK, Owens DGC, Johnstone EC. Magnetic resonance imaging of brain in people at high risk of developing schizophrenia. Lancet. 1999;353:30–33.[Medline] [Order article via Infotrieve]
23. Hajnal JV, De Coene B, Lewis PD, Baudin CJ, Cowan FM, Pennock JM, Young IR, Bydder GM. High signal regions in normal white matter shown by heavily T2 weighted CSF nulled IR sequences. J Comput Assist Tomogr. 1992;16:506–513.[Medline] [Order article via Infotrieve]
24.
Shah PJ, Ebmeier KP, Glabus MF, Goodwin GM. Cortical
grey matter reductions associated with treatment-resistant
chronic unipolar depression: controlled magnetic resonance imaging
study. Br J Psychiatry. 1998;172:527–532.
25. Friston RJ. Statistical parametric mapping. In: Thatcher RW, Hallet M, Zeffiro T, John ER, Huerta M, eds. Functional Neuroimaging. New York, NY: Academic Press; 1994.
26. Reed JM, Squire LR. Impaired recognition memory in patients with lesions limited to the hippocampal formation. Behav Neurosci. 1997;111:667–675.[Medline] [Order article via Infotrieve]
27.
Vargha-Khadem F, Gadian DG, Watkins KE, Connelly A, Van
Paesschen W, Mishkin M. Differential effects of early hippocampal
pathology on episodic and semantic memory. Science. 1997;277:376–380.
28. Markowitsch HJ, Weber-Luxemburger G, Ewald K, Kessler J, Heiss W-D. Patients with heart attacks are not valid models for medial temporal lobe amnesia: a neuropsychological and FDG-PET study with consequences for memory research. Eur J Neurol. 1997;4:178–184.
29. Wilson BA. Management and remediation of memory problems in brain-injured adults. In: Baddeley AD, Wilson BA, Watts FN, eds. Handbook of Memory Disorders. Chichester, UK: John Wiley & Sons Ltd; 1995.
30. Baddeley A, Wilson BA. When implicit learning fails: amnesia and the problem of error elimination. Neuropsychologia. 1994;32:53–68.[Medline] [Order article via Infotrieve]
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