doi: 10.1161/hs0901.095680
(Stroke. 2001;32:2021.)
© 2001 American Heart Association, Inc.
Original Contributions |
Utility of Perfusion-Weighted CT Imaging in Acute Middle Cerebral Artery Stroke Treated With Intra-Arterial Thrombolysis:
Prediction of Final Infarct Volume and Clinical Outcome
From the Departments of Radiology M.H.L., J.F., S.T.H., C.P., G.J.H., R.B., G.J.H., R.G.G.), Neurology (A.Z.S., F.S.B., W.J.K., L.S.), and Medicine (Y.C.), Massachusetts General Hospital, Harvard Medical School, Boston, and National Institute of Neurological Disorders and Stroke (M.A.E.), National Institutes of Health, Bethesda, Md.
Correspondence to Michael H. Lev, MD, Massachusetts General Hospital, Department of Radiology-GRB285, PO Box 9657, Boston, MA 02114-9657. E-mail mlev{at}partners.org
 |
Abstract |
|---|
 Top Abstract IntroductionSubjects and MethodsResultsDiscussionReferencesPerfusion-Weighted CT in Acute...References |
|---|
Background and Purpose—— The goal of this study was to evaluate the utility of perfusion-weighted CT (PWCT) in predicting final infarct volume and clinical outcome in patients with acute middle cerebral artery (MCA) stroke.
Methods—— Twenty-two consecutive patients with MCA stem occlusion who underwent intra-arterial thrombolysis within 6 hours of stroke onset had noncontrast CT and CT angiography with whole-brain PWCT imaging before treatment. Infarct volumes were computed from the initial PWCT and follow-up scans; clinical outcome was measured with the modified Rankin scale.
Results—— Initial PWCT lesion volumes correlated significantly with final infarct volume (P=0.0002) and clinical outcome (P=0.01). For the 10 patients with complete recanalization, the relationship between initial and final lesion volume was especially strong (R2=0.94, P<0.0001, slope of regression line=0.92). For those without complete recanalization, there was progression of lesion volume on follow-up imaging (R2=0.50, P=0.01, slope of regression line=1.61). All patients with either initial PWCT lesion volumes >100 mL or no recanalization had poor outcomes (Rankin scores, 4 to 6). Mean admission NIH Stroke Scale scores and mean lesion volumes in the poor outcome group were significantly different compared with the good or fair outcome (Rankin scores, 0 to 3) group (21±4 versus 17±5, P=0.05, and 106±79 versus 29±37 mL, P=0.01). Patients with initial volumes <100 mL and partial or complete recanalization all had good (Rankin scores, 0 to 2) or fair (Rankin score, 3) outcomes.
Conclusions—— Lesion volumes on admission PWCT images approximate final infarct volume for patients with early complete recanalization of MCA stem occlusion. For those without complete recanalization, there is subsequent enlargement of lesion volume on follow-up. Initial PWCT lesion volumes also have predictive value; volumes >100 mL are associated with a poor clinical outcome. In these highly selected patients, initial PWCT lesion volume was a stronger predictor of clinical outcome than was initial NIH Stroke Scale score.
Key Words: cerebral ischemia • stroke • thrombolysis • tomography, perfusion-weighted
|
Introduction |
|---|
|
TopAbstractIntroductionSubjects and MethodsResultsDiscussionReferencesPerfusion-Weighted CT in Acute...References |
|---|
Patient selection for intravenous or intra-arterial thrombolytic therapy involves weighing the risk of intracranial hemorrhage against the potential benefits of treatment. Decisions on acute stroke treatment could be facilitated by the use of imaging techniques that better predict clinical outcome and final infarct volume in response to successful revascularization.1 Increasingly, measures of cerebral perfusion have been advocated for predicting prognosis and guiding therapy.2–6
See Editorial Comment, page 2027
Dynamic contrast-enhanced CT imaging techniques, compared with more established MR techniques, are relatively newer methods of evaluating perfusion parameters such as cerebral blood volume (CBV) and cerebral blood flow (CBF).7–12 Because noncontrast CT (NCCT) imaging is routinely the first radiological test performed in the emergency assessment of acute stroke patients, the additional data supplied by CT angiographic (CTA) and perfusion-weighted CT (PWCT) imaging can be obtained rapidly and at relatively low cost. This additional contrast imaging is associated with minimal delays in treatment.7,12,13 We have used an imaging protocol for the evaluation of potential thrombolysis candidates with 3 components: a noncontrast head CT followed immediately by CTA with multislice whole-brain perfused blood volume (PWCT) acquisition. In this protocol, only a single helical CT scan acquisition, obtained during the dynamic administration of a single bolus of nonionic contrast, is required to simultaneously acquire both the CTA and the PWCT portions of the study, as described previously by Hunter et al.7
The clinical value of CTA imaging of circle of Willis occlusions or stenoses in acute stroke patients has been described previously.7,13–16 In this study, we report that simultaneously acquired PWCT images help to predict final infarct volume and clinical outcome in patients presenting with angiographically proven acute middle cerebral artery (MCA) embolic stroke.
|
Subjects and Methods |
|---|
|
TopAbstractIntroductionSubjects and MethodsResultsDiscussionReferencesPerfusion-Weighted CT in Acute...References |
|---|
We reviewed the clinical and imaging findings of 22 consecutive patients (10 women, 12 men; mean age, 73±11 years) who presented within 6 hours of onset of signs and symptoms suggesting proximal MCA occlusion (10 patients presented at <3 hours, 12 patients presented at 3 to 6 hours). NIH Stroke Scale (NIHSS) scores were recorded at the time of admission to the emergency department.17 All patients were referred by the neurology stroke service for noncontrast head CT scanning (NCCT), followed immediately by CTA of the circle of Willis and skull base vessels with concurrent CT CBV imaging (PWCT) performed according to the method of Hunter et al.7 All eligible patients underwent intra-arterial thrombolytic treatment per clinical protocol. Only patients with angiographically proven MCA occlusions were included in this analysis.
Scanning protocol was as follows. Standard NCCT scanning was performed in a headholder with a High Speed Advantage helical CT scanner (GE Medical Systems) in the emergency room. The nonhelical NCCT scanning technique was as follows: 120 kV, 170 mA, 2-second scan time, and 5-mm slice thickness. Coverage was from skull base to vertex of contiguous axial slices parallel to the planum sphenoidale.
NCCT scanning was followed immediately by helical scanning that used the following parameters: 3-mm helical beam collimation with a 3-mm/s table speed (pitch of 1), 220-mm scan field of view, coverage from skull base to vertex, 120 kV, maximal mA (usually mA=220), 90 to 120 cm3 nonionic contrast (Omnipaque 300, Nycomed Inc/Nycomed AS) at 3-mL/s injection rate via an 18-gauge intravenous line by power injector (Medrad), and a 25-second preparation delay between the onset of contrast infusion and the start of scanning. Helical scans were obtained with the same coverage and orientation as the noncontrast scans. This protocol was designed to provide simultaneous high-resolution vascular images of the intracranial circulation and, without additional scanning sequences or contrast administration, whole-brain 3-mm-thick axial perfused blood volume-weighted (PWCT) images.
After the completion of scanning, a neuroradiologist reconstructed the source images into standardized axial "collapsed" maximum intensity projection (MIP) views of the circle of Willis in real time during the patient encounter. Before the initiation of thrombolytic therapy, the NCCT and PWCT source images and reconstructions were interpreted by the treating neuroradiologist(s), acute stroke neurologist(s), and neurointerventionalist(s). NCCT images were evaluated for evidence of dense vessel sign, focal parenchymal low attenuation, hemorrhage, and sulcal effacement. CTA axial source images and circle of Willis MIP reconstructions were evaluated for the presence of a primary or secondary circle of Willis or skull base vessel occlusion. The 3-mm-thick postcontrast PWCT axial source images, obtained through the entire brain, were also evaluated for the presence of regions of relatively diminished contrast enhancement (ie, parenchymal blood pool deficits).
Intra-arterial urokinase infusion and mechanical clot manipulation were performed by a team of experienced interventional neuroradiologists using established techniques.18 Pretreatment and posttreatment arteriographic images of the involved MCA branches were obtained, and the elapsed time between stroke onset and recanalization or procedure termination was recorded. The arteriographic images and clinical records were retrospectively reviewed by a neuroradiologist and neurologist, who classified the success of recanalization as complete recanalization (M1 and M2 branches widely patent post thrombolysis, n=10), partial recanalization (M1 and 
1 but not all M2 branches patent, n=8), or no recanalization (persistent proximal MCA occlusion, n=4).
Follow-up NCCT imaging was available for 21 patients; T2-weighted MR imaging was used as an end point in 1 patient for whom follow-up NCCT was unavailable. Clinical outcome was measured by use of the modified Rankin score trichotomized into good (0 to 2), fair (3), and poor (4 to 6) outcomes.17,19 Follow-up Rankin scores were obtained by direct patient interviews as part of an Institutional Review Board-approved data collection process. In no case did a secondary clinical ischemic event occur between the time of thrombolysis and follow-up imaging or Rankin score determination.
Image analysis was performed by 3 readers experienced in the interpretation of stroke CT (1 stroke neuroradiologist and 2 stroke neurologists) who were blinded to patient identifiers, precise clinical histories, lateralization of symptoms, and clinical outcome scores but were aware of the suspicion for acute MCA stroke. All imaging studies were rated independently in a random order during multiple readout sessions spaced over 3 months; disagreements in ratings were resolved by consensus.
The initial NCCT and PWCT axial source images for each patient, along with the follow-up NCCT and, in 1 case, T2-weighted MR images, were transferred to an independent PC-based workstation with a 21-in-high resolution monitor (Nokia) for analysis. Care was taken to use optimal window width and center level settings during CT image review to maximize the contrast produced by the small attenuation difference between normal and ischemic, hypodense brain parenchyma.20
Computation of the initial PWCT hypodensity volumes and follow-up infarct volumes in the MCA territory was performed with a semi-automated image segmentation software package (Alice, Parexel Corp). For each CT, hypodense ischemic brain parenchyma was visually segmented by the reviewing neuroradiologist; the resulting volumes were independently confirmed at separate readout sessions by each of the remaining 2 reviewers. All regions chosen had at least a 4-Hounsfield unit attenuation difference between hypodense, ischemic brain and the surrounding normal brain parenchyma. Areas of hemorrhage and contrast blush, representing evolving infarction, were included in the follow-up NCCT lesion volumes. Areas of chronic infarction, identified as cavitary regions with sharp geographic borders in an appropriate vascular territory, were not included (n= 4). Only MCA territory ischemic volumes were segmented.
Volume segmentation of the initial NCCT images was not performed because the precise boundaries of the ischemic hypodense regions were much less conspicuous and difficult to define on the initial NCCT images than on the initial PWCT images. Instead, the degree of mismatch between the hypodense ischemic regions observed on the initial NCCT versus PWCT images was graded visually according to the following 3-point scale: 0=no mismatch (Figures 1 and 2), 1=small mismatch (PWCT hypodensity volume 10% to 30% larger than the NCCT), and 2=large mismatch (PWCT hypodensity volume >30% larger than the NCCT hypodensity volume, Figure 3). In rating mismatch, pairwise comparison of the images was done only after independent review of the NCCT images followed by the PWCT images.
|
|
|
ANOVA was used to examine the relationship between degree of recanalization and different parameters. Pairwise comparisons using Scheffé’s multiple comparison procedure were conducted only among those with overall significant probability value. Regression analysis of the initial PWCT hypodensity volumes with (1) final infarct volumes and (2) final clinical outcomes as measured by Rankin score was performed for all cases and again separately for each degree of recanalization. Pearson correlation coefficients were used to summarize the relationship between initial PWCT hypodensity and final stroke volumes. Linear regression models were used to examine the effects of initial PWCT hypodensity volume, degree of mismatch, timing between stroke onset and successful recanalization, NIHSS score, and degree of success of recanalization on both final infarct volume and clinical outcome. Mean NIHSS scores and lesion volumes for the good and fair versus poor outcome groups were compared by use of 1-tailed Student’s t test after an F test for variance.
|
Results |
|---|
|
TopAbstractIntroductionSubjects and MethodsResultsDiscussionReferencesPerfusion-Weighted CT in Acute...References |
|---|
Demographic Data and Clinical Outcome
The Table gives the demographic, clinical, and imaging data of all patients stratified by recanalization group (complete, partial, or no recanalization) for patient age and sex, initial NIHSS score, initial PWCT hypodensity volume, final infarct volume, initial PWCT>NCCT hypodensity volume mismatch score, final Rankin outcome score, and time from stroke onset to successful recanalization. Mean time to PWCT imaging was 2.2±0.4 hours after stroke (range, 1.0 to 4.9 hours). Mean time to successful recanalization was 4.7±1.8 hours (range, 2.9 to 6.7 hours). Of the 22 patients studied, 8 had no mismatch (mismatch score, 0), 7 had a small mismatch (mismatch score, 1), and 7 had a large mismatch (mismatch score, 2). Mean time to follow-up imaging was 5.0±5.9 days (range, 24 hours to 28 days). Mean time to clinical follow-up for living patients (Rankin score) was 7.1±5.2 months (range, 1 to 15 months); a Rankin score of 6 was recorded for 5 patients who died after stroke.
|
A statistically significant difference in final Rankin score was present between the 3 recanalization groups (P=0.007, ANOVA); the difference in final infarct volume between the 3 groups nearly reached significance (P=0.06). After adjustment for multiple comparisons, the only difference that remained significant at the P=0.05 level was the mean Rankin score for patients with complete versus no recanalization. There was no statistically significant relationship between the success of recanalization and size of the initial PWCT hypodensity, patient age, initial NIHSS score, or degree of PWCT>NCCT mismatch.
Final Infarct Volume Versus Initial PWCT Hypodensity Volume
Overall initial PWCT hypodensity volume correlated significantly with follow-up infarct volume by linear regression (Pearson’s R=0.72, P<0.002). The correlation between initial PWCT hypodensity and final infarct volume was strongest for the patient subgroups with complete recanalization (R2=0.94, P<0.0001) and partial recanalization (R2=0.80, P=0.003) and was less robust for the combined partial or no recanalization groups (R2=0.50, P=0.01). PWCT hypodensity volume did not predict final infarct volume in the subgroup with no recanalization (R2=0.14, P=0.62).
Initial perfusion-weighted lesion volume was slightly larger than final infarct volume in the complete recanalization group (slope of regression line, 0.92), whereas it was less than final infarct volume in the partial or no recanalization group (slope of regression line, 1.61; P=0.09 versus the complete recanalization group). For the no recanalization group, final infarct volume tended to be large (>100 mL), regardless of the size of the admission lesion. A scatterplot of these values, stratified according to the success of recanalization, along with linear regression lines for the complete versus pooled other patient subgroups, is shown in Figure 4.
|
The degree of PWCT>NCCT mismatch was next stratified as a dichotomous variable (absent versus present) and controlled for the outcome of recanalization. For the 8 cases without PWCT>NCCT mismatch, there was a stronger linear correlation between initial PWCT lesion volume and final infarct volume (R2=0.71, P=0.008) than for those cases with mismatch (R2=0.48, P=0.006). A scatterplot of initial versus final lesion volumes, with linear regression lines for the mismatch (slope, 1.6) and no mismatch (slope, 1.1) groups, is shown in Figure 5.
|
Clinical Outcome Versus Initial PWCT Hypodensity Volume
Clinical outcome (Rankin score) also correlated significantly by linear regression with initial PWCT lesion volume (Pearson’s R=0.53, P=0.01) but not with initial NIHSS score (Pearson’s R=0.33, P=0.13). A scatterplot of clinical outcome versus initial PWCT lesion volume, stratified by degree of recanalization, is shown in Figure 6. All patients with either initial PWCT lesion volumes >100 mL or no recanalization had poor outcomes (Rankin scores, 4 to 6). Mean admission NIHSS scores and mean lesion volumes in the poor outcome group were significantly different compared with the good or fair outcome (Rankin scores, 0 to 3) group (21±4 versus17±5, P=0.05, and 106±79 versus 29±37 mL, P=0.01). Patients with initial volumes <100 mL and partial or complete recanalization all had good (Rankin scores, 0 to 2) or fair (Rankin score, 3) outcomes.
|
Thus, an initial PWCT lesion volume >100 mL had 100% predictive value for a poor clinical outcome, and a value <100 mL (with complete or partial recanalization) had 77% positive predictive value for a good clinical outcome.
A significant linear relationship between outcome and initial lesion volume was present in the complete (R2=0.45, P=0.03) and partial (R2=0.49, P=0.05) recanalization groups but not in the no recanalization group (R2=0.08, P=0.71). Mean final Rankin score (the Table) was significantly lower (ie, better outcome) for patients with complete recanalization than for those with no recanalization (P<0.05 after multiple comparison adjustment). There was also a trend toward a significant difference in mean final Rankin score between the partial and no recanalization groups.
In cases without PWCT>NCCT mismatch, there was a significant relationship between clinical outcome and PWCT lesion volume (R2=0.74, P=0.006). However, in cases with mismatch, there was not a statistically significant relationship between outcome and PWCT (R2=0.06, P=0.39). Two patients with complete recanalization and mismatch scores of 2 had excellent clinical outcomes (Rankin scores 1; Figure 6) despite initial PWCT lesion volumes of just <100 mL.
|
Discussion |
|---|
|
TopAbstractIntroductionSubjects and MethodsResultsDiscussionReferencesPerfusion-Weighted CT in Acute...References |
|---|
We have shown that for patients with early complete revascularization after proximal MCA embolic occlusion, final infarct volume is approximated by the size of the initial ischemic lesion volume visualized on PWCT imaging. In patients with MCA occlusion, a small PWCT abnormality is considered an indicator of better leptomeningeal collateral blood flow, which promotes survival of ischemic brain tissue until reperfusion occurs.13,21 We also report that in this homogeneous, highly selected patient group, initial PWCT lesion volume is a stronger overall predictor of clinical outcome than is admission NIHSS score, especially for those with successful recanalization. In comparison, patients with partial recanalization demonstrate enlargement of their initial PWCT lesion volume on follow-up imaging, and clinical outcome is more likely to be worse. Post hoc analysis suggests that a cutoff volume of >100 mL may identify "poor" outcome patients. Those patients with no recanalization have large infarcts and poor clinical outcomes at follow-up, regardless of their initial PWCT lesion volumes. However, for the subset of patients whose initial PWCT lesion volumes are much larger than their corresponding NCCT lesion volumes (ie, large PWCT>NCCT mismatch), both final infarct volume and long-term clinical outcome after intra-arterial thrombolysis are more variable.
It is not surprising that perfused CBV, as imaged by PWCT imaging, should reflect approximate minimum final infarct size in this clinical setting.22,23 As cerebral perfusion pressure falls, precapillary resistance vessels dilate (ie, increased CBV) to maintain CBF. Once maximum vasodilatation has been reached, autoregulation fails and CBF begins to fall. Progressive increases in cerebral oxygen extraction can temporarily maintain cerebral oxygen metabolism. As perfusion pressure continues to fall, there is disruption of cellular metabolism, vascular collapse, and development of irreversible ischemia.22 In acute ischemic stroke, collapse of vessels at low CBV is likely to occur only after prolonged, severe reductions in CBF, and continued collapse would be associated with a high probability of producing infarction.2,24,25
Our data support the idea that visually conspicuous reductions in CBV, at a mean of 2
hours from onset of MCA occlusion, represent regions of oligemic brain tissue with high risk of infarction. Only 1 of our 22 cases demonstrated any significant sparing of brain tissue in a territory with initially depressed perfused blood volume. This was a case of very early PWCT imaging (1 hour after onset) and very early complete recanalization (<3 hours) of the occluded inferior MCA division (Figure 3). Studies of perfusion MRI and 99mTc-HMPAO single-photon emission CT in acute stroke patients have shown that the degree of CBV reduction in penumbral regions with borderline abnormal CBF might be useful in predicting tissue outcome.25 Lesion volume on admission CBV imaging has been shown to be a strong predictor of final infarct size.2,26,27 In our study, the slope of the linear regression line for the complete recanalization group is nearly unity (slope, 0.92; Figure 4). This suggests that at a mean time to recanalization of 4.7 hours, only a small margin of the PWCT lesion volume is typically salvageable.
Loss of the mismatch between initial NCCT and PWCT lesion volumes over time (ie, expansion of the initial NCCT lesion volume) may reflect "early" penumbral deterioration. Except in cases of very early revascularization, normal NCCT brain regions with abnormal PWCT will typically progress to infarction (Figures 2 and 3). The CBF lesion volume is generally larger than the CBV lesion volume, and enlargement of final infarct volume beyond the volume defined by the initial PWCT lesion volume may reflect "late" penumbral loss. Our data suggest that cases with a significant PWCT>NCCT lesion volume mismatch at admission are likely to have more variable final infarct volumes (Figure 5) and clinical outcomes than cases without mismatch. The NCCT lesion volumes, once visually evident, are strongly associated with irreversible infarction.28
Although we obtained quantitative PWCT lesion volumes using image segmentation software, we were forced to estimate the degree of mismatch by direct visual comparison between the abnormal NCCT and PWCT regions. Quantitative NCCT lesion volumes could not be reliably measured because of the indistinct margins and limited visual conspicuity typical of acute ischemic NCCT hypodensity. The attenuation differences between normal and edematous tissue on the initial NCCT images are typically only in the 1- to 3-Hounsfield unit range. Despite our careful use of optimal window width and center level display settings during NCCT image interpretation,20 our preliminary attempts to segment hypodense NCCT regions were characterized by marked intraobserver and interobserver variability. Indeed, many portions of the abnormal, hypodense brain tissue present on the admission NCCT images were detected only retrospectively during careful review of the NCCT scans alongside coregistered PWCT images. A potentially important role of PWCT imaging in acute stroke may be to improve detection of subtle NCCT findings of ischemia, a frequent problem in stroke clinical trials.
Our finding of a better clinical outcome for patients with complete recanalization than for those without recanalization is consistent with the report of a benefit of intra-arterial thrombolysis in the treatment of proximal MCA embolic stroke from the Prourokinase in Acute Cerebral Thromboembolism (PROACT) trial.29 It is noteworthy that in our study a PWCT lesion volume of 100 mL identified patients with a "poor" clinical outcome, because 100 mL is approximately equal to one third the brain volume supplied by an MCA.30 This result is consistent with the European data indicating that intravenous thrombolytic therapy within 6 hours of stroke onset results in poor outcome in patients with initial NCCT lesion volumes greater than one third that of the MCA territory.31,32
A limitation of our analysis is that it did not control for confounding medical conditions or final infarct location. Final infarct location sparing language and motor centers may help to explain the excellent clinical outcome in the 2 patients with initial mismatch scores of 2, despite initial PWCT lesion volumes of 
100 mL. Of the 3 of 13 patients with fair clinical outcomes who had initial lesion volumes <100 mL and partial or complete recanalization, 1 carried a diagnosis of Alzheimer’s disease, another had multiple severe concurrent medical illnesses, and the third had a small left basal ganglia hemorrhage at an anatomically critical location.
Helical CT scanners are typically more available and less expensive than MRI scanners and are frequently located in the emergency department setting. CTA with PWCT can be performed rapidly and conveniently immediately after the head NCCT examination routinely obtained to exclude hemorrhage before the consideration of thrombolytic therapy. The addition of a CTA/PWCT study is well tolerated by almost all stroke patients and seldom adds >15 minutes of scanning, postprocessing, and interpretation time to the time required for the clinically necessary NCCT examination. CTA reliably demonstrates large vessel occlusions amenable to intra-arterial thrombolysis.13–16 Despite differences in technique and the tissue characteristics they measure, both diffusion-weighted MR and PWCT imaging delineate ischemic regions likely to be irreversibly infarcted. Simultaneous review of both the NCCT and PWCT images allows a determination of mismatch between unequivocally infarcted tissue (ie, NCCT) and more conspicuous ischemic tissue with a high probability of infarction (ie, PWCT). More importantly, a small PWCT lesion (<100 mL) distal to an MCA occlusion identifies patients who will have a small final infarct and good outcome after successful thrombolysis. In contrast, stroke size will exceed the PWCT lesion volume if recanalization does not occur. By its ability to predict those patients more—rather than less—likely to benefit from MCA recanalization, PWCT can play an important role in guiding acute stroke treatment.
|
Acknowledgments |
|---|
This work was supported in part by NIH grants NS-34626 and RR-13213 (Dr Gonzalez) and by an educational grant from GE Medical Systems. Dr Lev is the recipient of a Radiological Society of North America Seed Grant Award.
Received November 15, 2000; revision received April 27, 2001; accepted June 25, 2001.
|
References |
|---|
|
TopAbstractIntroductionSubjects and MethodsResultsDiscussionReferencesPerfusion-Weighted CT in Acute...References |
|---|
1. Grotta JC, Chiu D, Lu M, Patel S, Levine SR, Tilley BC, Brott TG, Haley EC Jr, Lyden PD, Kothari R, Frankel M, Lewandowski CA, Libman R, Kwiatkowski T, Broderick JP, Marler JR, Corrigan J, Huff S, Mitsias P, Talati S, Tanne D. Agreement and variability in the interpretation of early CT changes in stroke patients qualifying for intravenous rtPA therapy. Stroke. 1999; 30: 1528–1533.
2.
Sorensen A, Copen W, Ostergaard L, Buonnano F, Gonzalez R, Rordof G, Rosen B, Schwamm L, Weiskoff R, Koroshetz W. Hyperacute stroke: simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow and mean tissue transit time. Radiology. 1999; 210: 519–527.
3.
Sunshine JL, Tarr RW, Lanzieri CF, Landis DMD, Selman WR, Lewin JS. Hyperacute stroke: ultrafast MR imaging to triage patients prior to therapy. Radiology. 1999; 212: 325–332.
4. Ueda T, Sakaki S, Yuh W, Nochide I, Ohta S. Outcome in acute stroke with successful intra-arterial thrombolysis procedure and predictive value of initial single-photon emission-computed tomography. J Cereb Blood Flow Metab. 1999; 19: 99–108.[Medline] [Order article via Infotrieve]
5.
Kaufmann AM, Firlik AD, Fukui MB, Wechsler LR, Jungries CA, Yonas H. Ischemic core and penumbra in human stroke. Stroke. 1999; 30: 93–99.
6.
Lee KH, Lee SJ, Cho SJ, Na DG, Byun HS, Kim YB, Song HJ, Jin IS, Chung CS. Usefulness of triphasic perfusion computed tomography for intravenous thrombolysis with tissue-type plasminogen activator in acute ischemic stroke. Arch Neurol. 2000; 57: 1000–1008.
7. Hunter GJ, Hamberg LM, Ponzo JA, Huang HF, Morris PP, Rabinov J, Farkas J, Lev MH, Schaefer PW, Ogilvy CS, Schwamm L, Buonanno FS, Koroshetz WJ, Wolf GL, Gonzalez RG. Assessment of cerebral perfusion and arterial anatomy in hyperacute stroke with three-dimensional functional CT: early clinical results. AJNR Am J Neuroradiol. 1998; 19: 29–37.[Abstract]
8. Hamberg LM, Hunter GJ, Halpern EF, Hoop B, Gazelle GS, Wolf GL. Quantitative high resolution measurement of cerebrovascular physiology with slip-ring CT. AJNR Am J Neuroradiol. 1996; 17: 639–650.[Abstract]
9.
Nabavi D, Cenic A, Craen R, Gelb A, Bennet J, Kozak R, Lee T. CT assessment of cerebral perfusion: experimental validation and initial clinical experience. Radiology. 1999; 213: 141–149.
10.
Cenic A, Nabavi D, Craen R, Gelb A, Lee T. Dynamic CT measurement of cerebral blood flow: a validation study. AJNR Am J Neuroradiol. 1999; 20: 63–73.
11.
Koenig M, Klotz E, Luka B, Venderink DJ, Spittler JF, Heuser L. Perfusion CT of the brain: diagnostic approach for early detection of ischemic stroke. Radiology. 1998; 209: 85–93.
12. Koroshetz W, Gonzales R. Imaging stroke in progress: magnetic resonance advances but computed tomography is poised for counterattack. Ann Neurol. 1999; 46: 556–558.[Medline] [Order article via Infotrieve]
13.
Wildermuth S, Knauth M, Brandt T, Winter R, Sartor K, Hacke W. Role of CT angiography in patient selection for thrombolytic therapy in acute hemispheric stroke. Stroke. 1998; 29: 935–938.
14. Shrier D, Tanaka H, Numaguchi Y, Konno S, Patel U, Shibata D. CT angiography in the evaluation of acute stroke. AJNR Am J Neuroradiol. 1997; 18: 1011–1020.[Abstract]
15. Knauth M, van Kummer R, Jansen O, Hahnel S, Dorfler A, Sartor K. Potential of CT angiography in acute ischemic stroke. AJNR Am J Neuroradiol. 1997; 18: 1001–1010.[Abstract]
16. Lev MH, Farkas J, Rodriguez VR, Schwamm LH, Hunter GJ, Putman CM, Rordorf GA, Buonanno F, Budzik R, Koroshetz WJ, Gonzalez RG. CT angiography in the rapid triage of patients with hyperacute stroke: accuracy in the detection of large vessel thrombus. J Comput Assist Tomogr. 2001; 25: 520–528.[Medline] [Order article via Infotrieve]
17.
Buchan AM, Barber PA, Newcommon N, Karbalai HG, Demchuk AM, Hoyte KM, Klein GM, Feasby TE. Effectiveness of t-PA in acute ischemic stroke: outcome relates to appropriateness. Neurology. 2000; 54: 679–684.
18. Budzik R, Pergolizzi R, Putman C. Intraarterial thrombolysis for acute ischemic stroke. Semin Neurosurg. 2000; 11: 107–132.
19. Wade D. Measurement in Neurological Rehabilitation. Oxford, UK: Oxford Medical Publications; 1994.
20.
Lev M, Farkas J, Gemmete J, Hossain S, Hunter G, Koroshetz W, Gonzalez R. Acute stroke: improved nonenhanced CT detection: benefits of soft-copy interpretation by using variable window width and center level settings. Radiology. 1999; 213: 150–155.
21.
Lee KH, Cho SJ, Byun HS, Na DG, Choi NC, Lee SJ, Jin IS, Lee TG, Chung CS. Triphasic perfusion computed tomography in acute middle cerebral artery stroke: a correlation with angiographic findings. Arch Neurol. 2000; 57: 990–999.
22. Powers W. Cerebral hemodynamics in ischemic cerebrovascular disease. Ann Neurol. 1991; 29: 231–240.[Medline] [Order article via Infotrieve]
23. Powers W, Grubb R, Darriet D, Raichle M. Cerebral blood flow and cerebral metabolic rate of oxygen requirements for cerebral function and viability in humans. J Cereb Blood Flow Metab. 1985; 5: 600–608.[Medline] [Order article via Infotrieve]
24. Jones T, Morawetz R, Crowell R, Marcoux F, Fitzgibbons S, DeGirolami U, Ojemann R. Thresholds of focal cerebral ischemia in awake monkeys. J Neurosurg. 1981; 54: 773–782.[Medline] [Order article via Infotrieve]
25.
Hatazawa J, Shimosegawa E, Toyoshima H, Ardekani BA, Suzuki A, Okudera T, Miura Y. Cerebral blood volume in acute brain infarction: a combined study with dynamic susceptibility contrast MRI and 99mTc-HMPAO-SPECT. Stroke. 1999; 30: 800–806.
26.
Ueda T, Yuh W, Maley J, Quets J, Hahn P, Magnotta V. Outcome of acute ischemic lesion evaluated by diffusion and perfusion MR imaging. AJNR Am J Neuroradiol. 1999; 20: 983–989.
27.
Karonen JO, Vanninen RL, Liu Y, Ostergaard L, Kuikka JT, Nuutinen J, Vanninen EJ, Partanen PL, Vainio PA, Korhonen K, Perkio J, Roivainen R, Sivenius J, Aronen HJ. Combined diffusion and perfusion MRI with correlation to single-photon emission CT in acute ischemic stroke: ischemic penumbra predicts infarct growth. Stroke. 1999; 30: 1583–1590.
28.
Grond M, von Kummer R, Sobesky J, Schmulling S, Rudolf J, Terstegge K, Heiss W. Early x-ray hypoattenuation of brain parenchyma indicates extended critical hypoperfusion in acute stroke. Stroke. 2000; 31: 133–139.
29.
Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, Callahan F, Clark W, Silver F, Rivera F. Intra-arterial prourokinase for acute ischemic stroke. JAMA. 1999; 282: 2003–2011.
30.
van der Zwan A, Hillen B, Tulleken CA, Dujovny M. A quantitative investigation of the variability of the major cerebral arterial territories. Stroke. 1993; 24: 1951–1959.
31.
von Kummer R, Allen KL, Holle R, Bozzao L, Bastianello S, Manelfe C, Bluhmki E, Ringleb P, Meier DH, Hacke W. Acute stroke: usefulness of early CT findings before thrombolytic therapy. Radiology. 1997; 205: 327–333.
32.
Kalafut MA, Schriger DL, Saver JL, Starkman S. Detection of early CT signs of >1/3 middle cerebral artery infarctions: interrater reliability and sensitivity of CT interpretation by physicians involved in acute stroke care. Stroke. 2000; 31: 1667–1671.
Editorial Comment
Prediction of Final Infarct Volume and Clinical Outcome
|
Perfusion-Weighted CT in Acute MCA Stroke: Teaching Old Dogs New Tricks |
|---|
|
TopAbstractIntroductionSubjects and MethodsResultsDiscussionReferencesPerfusion-Weighted CT in Acute...References |
|---|
Introduced in 1973, CT revolutionized the approach to stroke diagnosis. The standard role of noncontrast CT in acute stroke diagnosis quickly became the detection of brain hemorrhage. For the first time, clinicians could visually distinguish a brain hemorrhage from an infarction; it turned out that traditional clinical rules had often been wrong. Many papers appeared on infarction syndromes produced by hemorrhages; large infarctions with edema and mass effect were no longer misdiagnosed as hemorrhages. More accurate stroke diagnosis had an immediate impact on stroke epidemiology and therapy; clinicians could avoid blindly anticoagulating patients with brain hemorrhages.
For "acute" brain infarction (then defined as 48 hours), the standard teaching became that the CT was "normal" for the first 24 hours after stroke onset. Not until the era of thrombolysis did we realize that, in point of fact, the noncontrast CT was abnormal in the majority of patients with large-vessel infarction of <6 hours’ duration. The information had been there on CT for 20 years—we simply did not know what to look for because we were looking thru the wrong window (or a dirty window). First came the hyperdense middle cerebral artery (MCA) sign signifying MCA thrombosis. But the big change in early CT stroke diagnosis occurred in 1996 when the European Cooperative Acute Stroke Study (ECASS) linked early signs of infarction on CT in >1/3 of the MCA territory with hemorrhage risk and patient outcomes. Importantly, the ECASS investigators suggested that intravenous tissue plasminogen activator should not be given to such patients.1–6 Thus, noncontrast CT became a tool for therapeutic decision making rather than a purely anatomic imaging modality.
Recently acute stroke neuroimaging has focused on developing an "ECG" for acute stroke—a "stroke-o-gram"—that would define not only the type of stroke, but also the site of vessel occlusion, tissue at risk, and salvageable brain. MR with diffusion- and perfusion-weighted imaging combined with MR angiography has shown tremendous promise and received the most publicity in this regard, but there are huge logistical and technical barriers to obtaining emergency stroke MR in most hospitals. Noncontrast CT remains the standard acute stroke imaging modality. Taking advantage of this practicality and perhaps stimulated by the explosion of work in stroke MR, Lev et al now show that more acute stroke information can be unlocked from CT through perfusion-weighted imaging. The necessary ultrafast helical CT is potentially widely available in the emergency department setting and is less expensive than MR. A CT angiogram and perfusion-weighted CT images can be obtained simultaneously with a single injection of 100 cc of non-ionic contrast. However, it is not clear whether there are significant postprocessing delays and how quickly perfusion-weighted CT data can be made available to the clinician.
Perfusion-weighted CT employs concepts derived from acute stroke MR, although the technologies and terms are not strictly analogous. Indeed, correlations between noncontrast CT, perfusion-weighted CT, diffusion/perfusion-weighted MR, and clinical outcomes are lacking and require further investigation. Perfusion-weighted CT should not be confused with perfusion-weighted MR. Although measuring different tissue characteristics, the predictive features of perfusion-weighted CT are in many ways more analogous to diffusion-weighted MR than to perfusion-weighted MR. Perfusion-weighted CT reflects low cerebral blood volume within a collapsed vascular bed and thereby delineates the area of brain tissue doomed to infarction better than noncontrast CT. Perfusion-weighted CT is not a direct measure of tissue viability or function. Perfusion MR measures perturbed blood flow in normal or ischemic tissue and may better define brain tissue at risk or salvageable brain. As such, perfusion-weighted MR seems to correlate better with initial stroke severity (National Institutes of Health Stroke Scale score) than either diffusion-weighted MR or perfusion-weighted CT. The reversibility of perfusion-weighted CT changes is also unclear. Initially thought to represent irreversible infarction, it is now known that diffusion-weighted MR changes are reversible in some patients. The perfusion-weighted CT/noncontrast CT mismatch is therefore not analogous to the perfusion-weighted MR/diffusion-weighted MR mismatch. The apparent inability of perfusion-weighted CT to completely define brain tissue at risk ("penumbra") and the lack of quantification may distinguish perfusion-weighted CT from other emerging acute perfusion techniques such as MR and xenon CT.
Should we perform perfusion-weighted CT, perfusion/diffusion-weighted MR, both, or, as some have suggested, neither, to better understand and treat our patients with acute ischemic stroke? These new technologies all require further rigorous validation and correlation with clinical outcomes. Although it is too early to incorporate any of these technologies into routine clinical decision making, new technologies such as perfusion-weighted CT are obviously telling us things about acute stroke that we did not know before. Just as CT moved us from pure clinical description to anatomic depiction, it is only a matter of time before our imaging approach to acute ischemic stroke shifts to pathophysiological delineation. It is reassuring and exciting for this stroke neurologist to see that not only can an old dog learn new tricks, but that there are new dogs to attack the old trickster called stroke.
Section of Stroke and Neurological Critical Care
Department of Neurology
Cleveland Clinic
Cleveland, Ohio
|
References |
|---|
|
TopAbstractIntroductionSubjects and MethodsResultsDiscussionReferencesPerfusion-Weighted CT in Acute...References |
|---|
1. von Kummer R, Allen KL, Holle R, Bozzao L, Bastianello S, Manelfe C, Bluhmki E, Ringleb P, Meier DH, Hacke W. Acute stroke: usefulness of early CT findings before thrombolytic therapy. Radiology. 1997; 205: 327–333.
2. Warach S, Boska M, Welch K. Pitfalls and potential of clinical diffusion-weighted MR imaging in acute stroke. Stroke. 1997; 28: 481–482.
3. Zivin J. Diffusion-weighted MRI for diagnosis and treatment of ischemic stroke. Ann Neurol. 1997; 41: 567–568.[Medline] [Order article via Infotrieve]
4. Koroshetz W, Gonzalez G. Diffusion-weighted MRI and ECG for "brain attack?" Ann Neurol. 1997; 41: 565–566.[Medline] [Order article via Infotrieve]
5. Koroshetz W, Gonzalez R. Imaging stroke in progress: magnetic resonance advances but computed tomography is poised for counterattack. Ann Neurol. 1999; 46: 556–558.
6.
Albers GW. Expanding the window for thrombolytic therapy in acute stroke: the potential role of acute MRI for patient selection. Stroke. 1999; 30: 2230–2237.
This article has been cited by other articles:
 |
|
 |
|
  V. Puetz, P.N. Sylaja, M.D. Hill, S.B. Coutts, I. Dzialowski, U. Becker, G. Gahn, R. von Kummer, and A.M. Demchuk CT Angiography Source Images Predict Final Infarct Extent in Patients with Basilar Artery Occlusion AJNR Am. J. Neuroradiol., November 1, 2009; 30(10): 1877 - 1883. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Latchaw, M. J. Alberts, M. H. Lev, J. J. Connors, R. E. Harbaugh, R. T. Higashida, R. Hobson, C. S. Kidwell, W. J. Koroshetz, V. Mathews, et al. Recommendations for Imaging of Acute Ischemic Stroke: A Scientific Statement From the American Heart Association Stroke, November 1, 2009; 40(11): 3646 - 3678. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wintermark, H. A. Rowley, and M. H. Lev Acute Stroke Triage to Intravenous Thrombolysis and Other Therapies with Advanced CT or MR Imaging: Pro CT Radiology, June 1, 2009; 251(3): 619 - 626. [Full Text] [PDF]
|
|
|
|
|
|
R. Gasparotti, M. Grassi, D. Mardighian, M. Frigerio, M. Pavia, R. Liserre, M. Magoni, L. Mascaro, A. Padovani, and A. Pezzini Perfusion CT in Patients with Acute Ischemic Stroke Treated with Intra-Arterial Thrombolysis: Predictive Value of Infarct Core Size on Clinical Outcome AJNR Am. J. Neuroradiol., April 1, 2009; 30(4): 722 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kudo, M. Sasaki, K. Ogasawara, S. Terae, S. Ehara, and H. Shirato Difference in Tracer Delay-induced Effect among Deconvolution Algorithms in CT Perfusion Analysis: Quantitative Evaluation with Digital Phantoms Radiology, April 1, 2009; 251(1): 241 - 249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sasaki, K. Kudo, K. Ogasawara, and S. Fujiwara Tracer Delay-Insensitive Algorithm Can Improve Reliability of CT Perfusion Imaging for Cerebrovascular Steno-Occlusive Disease: Comparison with Quantitative Single-Photon Emission CT AJNR Am. J. Neuroradiol., January 1, 2009; 30(1): 188 - 193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Schaefer, A. J. Yoo, D. Bell, E. R. Barak, J. M. Romero, R. G. Nogueira, M. H. Lev, L. H. Schwamm, R. G. Gonzalez, and J. A. Hirsch CT Angiography-Source Image Hypoattenuation Predicts Clinical Outcome in Posterior Circulation Strokes Treated With Intra-Arterial Therapy Stroke, November 1, 2008; 39(11): 3107 - 3109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. de Lucas, E. Sanchez, A. Gutierrez, A. G. Mandly, E. Ruiz, A. F. Florez, J. Izquierdo, J. Arnaiz, T. Piedra, N. Valle, et al. CT Protocol for Acute Stroke: Tips and Tricks for General Radiologists1 RadioGraphics, October 1, 2008; 28(6): 1673 - 1687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.M. Provenzale, K. Shah, U. Patel, and D.C. McCrory Systematic Review of CT and MR Perfusion Imaging for Assessment of Acute Cerebrovascular Disease AJNR Am. J. Neuroradiol., September 1, 2008; 29(8): 1476 - 1482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.S. Rosenthal, L.H. Schwamm, L. Roccatagliata, S.B. Coutts, A.M. Demchuk, P.W. Schaefer, R.G. Gonzalez, M.D. Hill, E.F. Halpern, and M.H. Lev Role of Recanalization in Acute Stroke Outcome: Rationale for a CT Angiogram-Based "Benefit of Recanalization" Model AJNR Am. J. Neuroradiol., September 1, 2008; 29(8): 1471 - 1475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Puetz, P.N. Sylaja, S. B. Coutts, M. D. Hill, I. Dzialowski, P. Mueller, U. Becker, G. Urban, C. O'Reilly, P. A. Barber, et al. Extent of Hypoattenuation on CT Angiography Source Images Predicts Functional Outcome in Patients With Basilar Artery Occlusion Stroke, September 1, 2008; 39(9): 2485 - 2490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.M. Silvennoinen, L.M. Hamberg, P.J. Lindsberg, L. Valanne, and G.J. Hunter CT Perfusion Identifies Increased Salvage of Tissue in Patients Receiving Intravenous Recombinant Tissue Plasminogen Activator within 3 Hours of Stroke Onset AJNR Am. J. Neuroradiol., June 1, 2008; 29(6): 1118 - 1123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. B. Goldstein Acute Ischemic Stroke Treatment in 2007 Circulation, September 25, 2007; 116(13): 1504 - 1514. [Full Text] [PDF]
|
|
|
|
|
|
E. C. S. Camargo, K. L. Furie, A. B. Singhal, L. Roccatagliata, M. E. Cunnane, E. F. Halpern, G. J. Harris, W. S. Smith, R. G. Gonzalez, W. J. Koroshetz, et al. Acute Brain Infarct: Detection and Delineation with CT Angiographic Source Images versus Nonenhanced CT Scans Radiology, August 1, 2007; 244(2): 541 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Banks and C. A. Marotta Outcomes Validity and Reliability of the Modified Rankin Scale: Implications for Stroke Clinical Trials: A Literature Review and Synthesis Stroke, March 1, 2007; 38(3): 1091 - 1096. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Meschia, L. D. Case, B. B. Worrall, R. D. Brown Jr, T. G. Brott, M. Frankel, S. Silliman, S. S. Rich, and for the Ischemic Stroke Genetics Study Group Family history of stroke and severity of neurologic deficit after stroke Neurology, October 24, 2006; 67(8): 1396 - 1402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.D. Murphy, A.J. Fox, D.H. Lee, D.J. Sahlas, S.E. Black, M.J. Hogan, S.B. Coutts, A.M. Demchuk, M. Goyal, R.I. Aviv, et al. Identification of Penumbra and Infarct in Acute Ischemic Stroke Using Computed Tomography Perfusion-Derived Blood Flow and Blood Volume Measurements Stroke, July 1, 2006; 37(7): 1771 - 1777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Thomas, L. H. Schwamm, and M. H. Lev Case records of the Massachusetts General Hospital. Case 16-2006. A 72-year-old woman admitted to the emergency department because of a sudden change in mental status. N. Engl. J. Med., May 25, 2006; 354(21): 2263 - 2271. [Full Text] [PDF]
|
|
|
|
|
|
A. Srinivasan, M. Goyal, P. Stys, M. Sharma, and C. Lum Microcatheter navigation and thrombolysis in acute symptomatic cervical internal carotid occlusion. AJNR Am. J. Neuroradiol., April 1, 2006; 27(4): 774 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.W. Schaefer, L. Roccatagliata, C. Ledezma, B. Hoh, L.H. Schwamm, W. Koroshetz, R.G. Gonzalez, and M.H. Lev First-Pass Quantitative CT Perfusion Identifies Thresholds for Salvageable Penumbra in Acute Stroke Patients Treated with Intra-arterial Therapy AJNR Am. J. Neuroradiol., January 1, 2006; 27(1): 20 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. Schwamm, E. S. Rosenthal, C. J. Swap, J. Rosand, G. Rordorf, F. S. Buonanno, M. G. Vangel, W. J. Koroshetz, and M. H. Lev Hypoattenuation on CT Angiographic Source Images Predicts Risk of Intracerebral Hemorrhage and Outcome after Intra-Arterial Reperfusion Therapy AJNR Am. J. Neuroradiol., August 1, 2005; 26(7): 1798 - 1803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Sims, G. Rordorf, E. E. Smith, W. J. Koroshetz, M. H. Lev, F. Buonanno, and L. H. Schwamm Arterial Occlusion Revealed by CT Angiography Predicts NIH Stroke Score and Acute Outcomes after IV tPA Treatment AJNR Am. J. Neuroradiol., February 1, 2005; 26(2): 246 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Hjort, K. Butcher, S.M. Davis, C.S. Kidwell, on behalf of the UCLA Thrombolysis Investigators, W.J. Koroshetz, J. Rother, P.D. Schellinger, S. Warach, and L. Ostergaard Magnetic Resonance Imaging Criteria for Thrombolysis in Acute Cerebral Infarct Stroke, February 1, 2005; 36(2): 388 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wintermark, N. J. Fischbein, W. S. Smith, N. U. Ko, M. Quist, and W. P. Dillon Accuracy of Dynamic Perfusion CT with Deconvolution in Detecting Acute Hemispheric Stroke AJNR Am. J. Neuroradiol., January 1, 2005; 26(1): 104 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Coutts, M. H. Lev, M. Eliasziw, L. Roccatagliata, M. D. Hill, L. H. Schwamm, J.H. W. Pexman, W. J. Koroshetz, M. E. Hudon, A. M. Buchan, et al. ASPECTS on CTA Source Images Versus Unenhanced CT: Added Value in Predicting Final Infarct Extent and Clinical Outcome Stroke, November 1, 2004; 35(11): 2472 - 2476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Kloska, D. G. Nabavi, C. Gaus, E.-M. Nam, E. Klotz, E. B. Ringelstein, and W. Heindel Acute Stroke Assessment with CT: Do We Need Multimodal Evaluation? Radiology, October 1, 2004; 233(1): 79 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wintermark, G. van Melle, P. Schnyder, J.-P. Revelly, F. Porchet, L. Regli, R. Meuli, P. Maeder, and R. Chiolero Admission Perfusion CT: Prognostic Value in Patients with Severe Head Trauma Radiology, July 1, 2004; 232(1): 211 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Schramm, P. D. Schellinger, E. Klotz, K. Kallenberg, J. B. Fiebach, S. Kulkens, S. Heiland, M. Knauth, and K. Sartor Comparison of Perfusion Computed Tomography and Computed Tomography Angiography Source Images With Perfusion-Weighted Imaging and Diffusion-Weighted Imaging in Patients With Acute Stroke of Less Than 6 Hours' Duration Stroke, July 1, 2004; 35(7): 1652 - 1658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Husain Clinical and radiological predictors of recanalisation: time to define a rapid scoring system J. Neurol. Neurosurg. Psychiatry, June 1, 2004; 75(6): 811 - 812. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wintermark, D. Lepori, J. Cotting, E. Roulet, G. van Melle, R. Meuli, P. Maeder, L. Regli, F. R. Verdun, T. Deonna, et al. Brain Perfusion in Children: Evolution With Age Assessed by Quantitative Perfusion Computed Tomography Pediatrics, June 1, 2004; 113(6): 1642 - 1652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wintermark, W. S. Smith, N. U. Ko, M. Quist, P. Schnyder, and W. P. Dillon Dynamic Perfusion CT: Optimizing the Temporal Resolution and Contrast Volume for Calculation of Perfusion CT Parameters in Stroke Patients AJNR Am. J. Neuroradiol., May 1, 2004; 25(5): 720 - 729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H S Markus Cerebral perfusion and stroke J. Neurol. Neurosurg. Psychiatry, March 1, 2004; 75(3): 353 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. S. Carter, J. D. Rabinov, R. Pfannl, and L. H. Schwamm Case 5-2004 - A 57-Year-Old Man with Slurred Speech and Left Hemiparesis N. Engl. J. Med., February 12, 2004; 350(7): 707 - 716. [Full Text] [PDF]
|
|
|
|
|
|
M. Kaste Reborn Workhorse, CT, Pulls the Wagon Toward Thrombolysis Beyond 3 Hours Stroke, February 1, 2004; 35(2): 357 - 359. [Full Text] [PDF]
|
|
|
|
 |
|
 L. B. Goldstein Blood Pressure Management in Patients With Acute Ischemic Stroke Hypertension, February 1, 2004; 43(2): 137 - 141. [Full Text] [PDF]
|
|
|
|
|
|
J. H. Burdette Is CT Perfusion Ready for Prime Time? AJNR Am. J. Neuroradiol., January 1, 2004; 25(1): 3 - 4. [Full Text] [PDF]
|
|
|
|
|
|
J. M. Provenzale, R. Jahan, T. P. Naidich, and A. J. Fox Assessment of the Patient with Hyperacute Stroke: Imaging and Therapy Radiology, November 1, 2003; 229(2): 347 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Eastwood, M. H. Lev, M. Wintermark, C. Fitzek, D. P. Barboriak, D. M. Delong, T.-Y. Lee, T. Azhari, M. Herzau, V. R. Chilukuri, et al. Correlation of Early Dynamic CT Perfusion Imaging with Whole-Brain MR Diffusion and Perfusion Imaging in Acute Hemispheric Stroke AJNR Am. J. Neuroradiol., October 1, 2003; 24(9): 1869 - 1875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Hill, H. A. Rowley, F. Adler, M. Eliasziw, A. Furlan, R. T. Higashida, L. R. Wechsler, H. C. Roberts, W. P. Dillon, N. J. Fischbein, et al. Selection of Acute Ischemic Stroke Patients for Intra-Arterial Thrombolysis With Pro-Urokinase by Using ASPECTS Stroke, August 1, 2003; 34(8): 1925 - 1931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. F. Tomandl, E. Klotz, R. Handschu, B. Stemper, F. Reinhardt, W. J. Huk, K.E. Eberhardt, and S. Fateh-Moghadam Comprehensive Imaging of Ischemic Stroke with Multisection CT RadioGraphics, May 1, 2003; 23(3): 565 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. P. Adams Jr, R. J. Adams, T. Brott, G. J. del Zoppo, A. Furlan, L. B. Goldstein, R. L. Grubb, R. Higashida, C. Kidwell, T. G. Kwiatkowski, et al. Guidelines for the Early Management of Patients With Ischemic Stroke: A Scientific Statement From the Stroke Council of the American Stroke Association Stroke, April 1, 2003; 34(4): 1056 - 1083. [Full Text] [PDF]
|
|
|
|
|
|
R. E. Latchaw, H. Yonas, G. J. Hunter, W. T.C. Yuh, T. Ueda, A. G. Sorensen, J. L. Sunshine, J. Biller, L. Wechsler, R. Higashida, et al. Guidelines and Recommendations for Perfusion Imaging in Cerebral Ischemia: A Scientific Statement for Healthcare Professionals by the Writing Group on Perfusion Imaging, From the Council on Cardiovascular Radiology of the American Heart Association Stroke, April 1, 2003; 34(4): 1084 - 1104. [Full Text] [PDF]
|
|
|
|
|
|
K. Kudo, S. Terae, C. Katoh, M. Oka, T. Shiga, N. Tamaki, and K. Miyasaka Quantitative Cerebral Blood Flow Measurement with Dynamic Perfusion CT Using the Vascular-Pixel Elimination Method: Comparison with H215O Positron Emission Tomography AJNR Am. J. Neuroradiol., March 1, 2003; 24(3): 419 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Schellinger, J. B. Fiebach, W. Hacke, and J. Rother Imaging-Based Decision Making in Thrombolytic Therapy for Ischemic Stroke: Present Status Stroke, February 1, 2003; 34(2): 575 - 583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Eastwood, M. H. Lev, and J. M. Provenzale Perfusion CT with Iodinated Contrast Material Am. J. Roentgenol., January 1, 2003; 180(1): 3 - 12. [Full Text] [PDF]
|
|
|
|
|
|
M. H. Lev, W. J. Koroshetz, L. H. Schwamm, R. G. Gonzalez, and T. Tatlisumak CT or MRI for Imaging Patients with Acute Stroke: Visualization of "Tissue at Risk"? Stroke, December 1, 2002; 33(12): 2736 - 2737. [Full Text] [PDF]
|
|
|
|
|
|
D. G. Nabavi, S. P. Kloska, E.-M. Nam, M. Freund, C. G. Gaus, E. Klotz, W. Heindel, and E. B. Ringelstein MOSAIC: Multimodal Stroke Assessment Using Computed Tomography: Novel Diagnostic Approach for the Prediction of Infarction Size and Clinical Outcome Stroke, December 1, 2002; 33(12): 2819 - 2826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. S. Caviness, N. Makris, E. Montinaro, N. T. Sahin, J. F. Bates, L. Schwamm, D. Caplan, and D. N. Kennedy Anatomy of Stroke, Part I: An MRI-Based Topographic and Volumetric System of Analysis Stroke, November 1, 2002; 33(11): 2549 - 2556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Schramm, P. D. Schellinger, J. B. Fiebach, S. Heiland, O. Jansen, M. Knauth, W. Hacke, and K. Sartor Comparison of CT and CT Angiography Source Images With Diffusion-Weighted Imaging in Patients With Acute Stroke Within 6 Hours After Onset Stroke, October 1, 2002; 33(10): 2426 - 2432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. O. Zaidat, J. I. Suarez, C. Santillan, J. L. Sunshine, R. W. Tarr, V. H. Paras, W. R. Selman, D. M.D. Landis, and D. D. Tong Response to Intra-Arterial and Combined Intravenous and Intra-Arterial Thrombolytic Therapy in Patients With Distal Internal Carotid Artery Occlusion * Editorial Comment Stroke, July 1, 2002; 33(7): 1821 - 1827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Lev CT/MR Perfusion Imaging and Alphabet Soup: An Appeal for Standardized Nomenclature AJNR Am. J. Neuroradiol., May 1, 2002; 23(5): 746 - 747. [Full Text] [PDF]
|
|
|
|
|
|
M. A. Ezzeddine, M. H. Lev, C. T. McDonald, G. Rordorf, J. Oliveira-Filho, F. G. Aksoy, J. Farkas, A. Z. Segal, L. H. Schwamm, R. G. Gonzalez, et al. CT Angiography With Whole Brain Perfused Blood Volume Imaging: Added Clinical Value in the Assessment of Acute Stroke Stroke, April 1, 2002; 33(4): 959 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Can PWCT in Acute Stroke Predict Outcome After Thrombolytic Therapy? Journal Watch Neurology, November 21, 2001; 2001(1121): 3 - 3. [Full Text]
|
|
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||