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(Stroke. 2003;34:2103.)
© 2003 American Heart Association, Inc.
Original Contributions |
From the Stroke Unit, Department of Neurology, Ramos Mejia Hospital, Buenos Aires University, Argentina (G.S.), and Stroke Unit, Department of Neurological Sciences, Hospital-Clínica Kennedy, Guayaquil, Ecuador (O.H. Del B.).
Correspondence to Gustavo Saposnik, MD, Charcas 4431 4 "10," Buenos Aires 1425, Argentina. E-mail gsaposnik{at}intramed.net.ar
| Abstract |
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Methods We performed a systematic review of articles on stroke in South America, with emphasis on those providing information on the incidence and prevalence of stroke (community-based studies) and the pattern of stroke subtypes (hospital-based studies).
Results Seven papers provided information on stroke epidemiology; 11 gave data on the pattern of stroke subtypes. Community-based studies showed crude stroke prevalence rates ranging from 1.74 to 6.51 per 1000 and annual incidence rates from 0.35 to 1.83 per 1000. Hospital-based stroke registries consistently reported a high frequency of intracranial hemorrhages, which accounted for 26% to 46% of all strokes. Among patients with cerebral infarctions, intracranial atherosclerotic lesions and small-vessel disease have been common pathogenic mechanisms underlying the stroke. In most studies, hypertensive arteriolopathy was the most common cause of both infarctions and hemorrhages.
Conclusions Stroke has been poorly studied in South America. Available data suggest that the prevalence and incidence of stroke are lower than in developing countries. The pattern of stroke subtypes seems to be different from that reported in other regions of the world, with a higher frequency of cerebral hemorrhages, small-vessel disease, and intracranial atherosclerotic lesions. Such differences may be related to genetic, environmental, or sociocultural factors and to differences in the control of stroke risk factors.
Key Words: epidemiology ethnicity incidence intracerebral hemorrhage prevalence primary prevention South America stroke stroke classification
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| Methods |
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See Editorial Comment, page 2107
included if the design of the study was adequately described in the methods section and if stroke was diagnosed on the basis of neuroimaging findings.
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Studies on Stroke Epidemiology
Of the 7 community-based studies meeting inclusion criteria, 3 were designed primarily to assess the prevalence or incidence of stroke13; the other 4 were conducted to determine the prevalence or incidence of major neurological diseases47 (Table 1).
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The first study designed to assess stroke epidemiology was performed in Cuzco, a Peruvian city of 210 000 inhabitants located 3380 m above sea level.1 Twenty-one cases of first-ever stroke were found among 3246 screened individuals >15 years old. This gave a crude prevalence rate of 6.2 per 1000 population. Six of these 21 stroke cases occurred in the year before the study, giving a crude annual incidence rate of 1.83 per 1000. Age, alcohol consumption, polycythemia, and high income levels were positively associated with stroke prevalence. The authors noted the importance of environmental factors and lifestyle as contributors to stroke occurrence.
In a Colombian study conducted in the city of Sabaneta, 76 of 13 588 screened people (from 17 659 inhabitants) had a stroke.8 This gave a crude stroke prevalence rate of 5.6 per 1000. The annual incidence rate of stroke was 0.89 per 1000. This low incidence rate could be related to the implementation of campaigns directed at teaching the community about the hazards of stroke risk factors. Another prevalence study was conducted in rural areas of Santa Cruz (Bolivia).3 Of 9955 screened inhabitants, 16 had a stroke. This gave a crude prevalence of stroke of 1.74 per 1000. The prevalence was 2-fold higher in men than in women. It was suggested that this low prevalence rate could be related to a high number of stroke fatalities.
In a study designed to assess the epidemiology of neurological diseases in the Andean village of Quiroga (Ecuador), 4 of 1113 screened people had a stroke, yielding a crude prevalence rate of 3.6 per 1000.4 In a Colombian study screening 16 032 people from 7 different rural and urban communities, the crude stroke prevalence rate was 6.5 per 1000, which was higher in people living in urban areas (9.6 per 1000) compared with that found in those living in rural areas (4.1 per 1000).5 In another Colombian study conducted in the rural area of Aratoca, 10 of 544 screened people (from 6664 inhabitants) had a stroke; this gave a crude prevalence rate of 4.7 per 1000.6 In a Bolivian study on the incidence of neurological diseases among a small Amazonian tribe, 2 of 1514 individuals followed up over 1 year had a stroke, yielding an annual incidence rate of 0.35 per 1000.7
Studies on Stroke Subtypes
Of the 11 hospital-based stroke registries meeting inclusion criteria, 6 evaluated patients with both ischemic and hemorrhagic strokes,813 4 included patients with ischemic stroke,1417 and 1 evaluated patients with intracranial hemorrhages.18 Eight of the 11 studies included adult patients of all ages,812,14,15,17 and the other 3 were restricted to young adults.13,16,18
In Guayaquil, 500 Ecuadorian mestizos with stroke were evaluated.8 The authors found 37.4% of strokes were intracranial hemorrhages and 62.6% were cerebral infarctions. Hypertensive arteriolopathy was the cause of 64% of the hemorrhages and 43% of the infarctions. Lacunar infarctions were seen in 39% of patients with ischemic stroke. This was the first study to suggest that stroke patterns in South America are different from those seen in developed countries. Subsequent studies confirmed that intracranial hemorrhages are more prevalent (Table 2) and that the pattern of ischemic strokes is different in South America than in developed countries (Table 3).
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In Joinville (Brazil), 73.4% of 429 stroke patients had a cerebral infarction, 25.9% had an intracranial hemorrhage, and 0.7% had unclassified stroke.9 Arterial hypertension was the most common risk factor for ischemic and hemorrhagic strokes. Similar figures were observed in a stroke registry from Santiago (Chile) that included 450 patients.10 Of them, 51% had ischemic strokes, 34% had cerebral hemorrhages, 12% had subarachnoid hemorrhages, and 3% had transient ischemic attacks. Arterial hypertension was observed in 64% of these patients and was the most common cause of both infarctions and hemorrhages.
Another study conducted in Buenos Aires (Argentina) identified differences in risk factors and stroke subtypes between Argentinian natives and whites.11 The authors found a high frequency of hemorrhagic strokes and small-vessel disease in both ethnic groups. Hemorrhages were significantly higher in Argentinian natives than in whites (34% versus 27%), and whites had a nonsignificantly higher tendency of penetrating artery disease than natives (35% versus 24%). The same authors compared the frequency of stroke subtypes among whites living in Buenos Aires and Boston and found that the former had a higher frequency of hemorrhagic strokes (27% versus 15%) and small-vessel disease (35% versus 21%).12
Among 119 patients with cerebral infarction studied in Bogota (Colombia), only 19% had large-vessel atherosclerosis as the cause of stroke.14 In Santiago, 2 study of 110 patients with ischemic stroke suggested that the prevalence of extracranial carotid artery atherosclerosis is low among Chilean patients with cerebral infarctions,15 and other study from Guayaquil showed that 60% of Ecuadorian mestizos with cerebral infarctions related to large-artery atherosclerosis had intracranial lesions, located mostly in the middle cerebral artery stem.17
Stroke subtypes in young adults have also been evaluated in some studies. In a series from Sao Paolo (Brazil) that included 106 patients 15 to 40 years of age with cerebral infarction, cardioembolism was the most common pathogenetic mechanism of stroke in the subgroup of patients 30 to 40 years of age, whereas other determined causes of stroke were most often seen among patients <29 years of age. Lacunar infarctions were more common in patients >30 years of age.16 There was a predominance of women among patients <29 years of age and of men in patients 30 to 40 years of age. The authors concluded that the pathogenesis of ischemic stroke in young adults varies according to age and sex. In a series of 151 young adults (15 to 44 years of age) with intracranial hemorrhage from Guayaquil, hypertensive arteriolopathy was the leading cause of bleeding (39.7% of cases).18 In Curitiba (Brazil), another series of 164 young adults with stroke (86% ischemic) also showed that arterial hypertension was the most common risk factor for the occurrence of both ischemic and hemorrhagic strokes.13
| Discussion |
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Stroke incidence is more difficult to assess than prevalence when resources that allow prospective follow-up of a community are limited. The 3 studies on stroke incidence in South America yielded rates ranging from 0.35 to 1.83 per 1000 population,1,2,5 which are lower than that of developed countries. However, those geographically restricted studies may not reflect the situation of the entire continent.
Another conclusion that can be drawn from South American studies is the consistently reported high percentage of patients with intracranial hemorrhages among stroke sufferers, which is 2 to 3 times higher than that seen in people living in developed countries.812 Several factors may explain such differences, including a higher prevalence of uncontrolled arterial hypertension, dietary habits, widespread abuse of over-the-counter medications that predispose to bleeding, and alcohol abuse. Among patients with ischemic strokes, stroke registries suggest that intracranial atherosclerotic lesions and penetrating small-vessel disease are more common in South America than in developed countries.8,1012,1416
An unsolved puzzle is the contribution of racial-ethnic factors to the particular expression of stroke patterns. The South American population is heterogeneous and includes native Indians, immigrants of all races, and a number of racial admixtures. Therefore, it is difficult to group the patients according to race or ethnic group even after considering skin color or last names. Likewise, lifestyles, dietary habits, and environmental conditions are not uniform in South America, and results from a given study may not extrapolate to the entire region. It is important to describe ethnic subgroups to better understand stroke differences among different populations. The term "Hispanic," used in US stroke studies to refer to people coming from Latin America, should be banned from South American studies attempting to evaluate the role of race-ethnicity in the pattern of disease expression. A more specific classification using terms such as whites, blacks, mestizos, mulattos, and natives may be of more value in this setting.
In summary, much has to be learned about stroke in South America. Large-scale, multicentric community- and hospital-based studies with standarized designs that make them comparable to each other are urgently needed to increase our knowledge of the epidemiology and patterns of stroke subtypes in South America.
| Acknowledgments |
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Received May 7, 2003; revision received May 28, 2003; accepted May 30, 2003.
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