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(Stroke. 2007;38:e111.)
© 2007 American Heart Association, Inc.

Letters to the Editor

Two Common Gene Variants on Chromosome 9 and Risk of Atherothrombosis

The Center for Cardiovascular Disease Prevention, The Donald W. Reynolds Center for Cardiovascular Research, The Leducq Center for Molecular and Genetic Epidemiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass

To the Editor:

McPherson et al recently reported (in the journal Science) the association of 2 single nucleotide polymorphisms (rs10757274 and rs2383206) with coronary heart disease (CHD).¹ After their report, we examined the possible association of these 2 gene variants with atherothrombotic events using a prospective, nested, matched case-control design among initially healthy US white men participating in the Physicians’ Health Study. The baseline characteristics of the sample participants used have been described elsewhere.^2,3 Genotypes were determined on 335 myocardial infarction (MI) case-control pairs, and 254 ischemic stroke (IsST) case-control pairs; all matched on age ±2 years, smoking status, and time of follow-up. Our observed allele frequencies were similar to those reported by McPherson et al: the rs10757274 G-allele frequencies were 0.467, 0.430, 0.508, and 0.506 for MI-controls, MI-cases, IsST-controls, and IsST-cases, respectively; and the rs2383206 G-allele frequencies were 0.565, 0.599, 0.537, and 0.534 for MI-controls, MI-cases, IsST-controls, and IsST-cases, respectively. Overall, we found little evidence of association between the rs10757274 variant and incident MI or IsST (Table). By contrast, although statistically nonsignificant, the magnitude and direction of the effect estimate for rs2383206 with risk of MI were similar to the CHD risk estimates reported by McPherson et al. These data highlight the complexity of genetic association studies designed to dissect heritable patterns in common human disorders.

Acknowledgments

Sources of Funding

Supported by grants from the National Heart Lung and Blood Institute (HL-58755, and HL-63293), the Doris Duke Charitable Foundation, the American Heart Association, the Donald W. Reynolds Foundation, Las Vegas, Nevada, and the Leducq Foundation, Paris, France.

Disclosures

None.

References

1. McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, Hinds DA, Pennacchio LA, Tybjaerg-Hansen A, Folsom AR, Boerwinkle E, Hobbs HH, Cohen JC. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007; 316: 1488–1491.[Abstract/Free Full Text]

2. Zee RY, Cheng S, Hegener HH, Erlich HA, Ridker PM. Genetic variants of arachidonate 5-lipoxygenase-activating protein, and risk of incident myocardial infarction and ischemic stroke: a nested case-control approach. Stroke. 2006; 37: 2007–2011.[Abstract/Free Full Text]

3. Hegener HH, Lee IM, Cook NR, Ridker PM, Zee RY. Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study. Clin Chem. 2006; 52: 2021–2027.[Abstract/Free Full Text]

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This Article Extract Full Text (PDF) All Versions of this Article: 38/10/e111    most recent STROKEAHA.107.497669v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zee, R. Y.L. Articles by Ridker, P. M Search for Related Content PubMed PubMed Citation Articles by Zee, R. Y.L. Articles by Ridker, P. M