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(Stroke. 2007;38:e31.)
© 2007 American Heart Association, Inc.

Letters to the Editor

Cardiac Surgery for Infective Endocarditis, Complicated by Septic Cardioembolic Stroke

Department of Intensive Care University College of London Hospital London, UK

Alexander Bindels, MD, PhD

Department of Intensive Care, Catharina Hospital, Eindhoven, The Netherlands

Peter Pickkers, MD, PhD Hans G. van der Hoeven, MD, PhD

Department of Intensive Care, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

To the Editor:

We would like to comment on the recent article written by Dr Ruttmann et al on neurological outcome of cardiac surgery for infective endocarditis complicated by septic cardioembolic stroke.¹ We congratulate the authors on their extensive and thorough research, which demonstrates that early surgical intervention appears to be safer than was previously thought. There is, nonetheless, an important question that remains unanswered, and we hope the authors will be able to respond.

In our view, the results of the study of Ruttmann do not answer the question whether surgery is always indicated in patients with infective endocarditis complicated by cerebral embolism. Performing cardiac surgery in every patient with infective endocarditis with an episode of cerebral embolism but without cardiac failure is—in many countries—not the first choice of therapy and is certainly not supported by a lot of evidence.² Moreover, in their introduction, Dr Ruttmann et al state that the risk of septic cerebral embolism affecting the course of infective endocarditis is 40% and the recurrence rate is >50% and even up to 80% in patients with a short duration of clinical symptoms.¹ In the referenced study³ performed in 288 patients, in 17.4% of the patients the clinical course was complicated by one and in 20.2% by recurrent embolism of which 71% was cerebral. To our knowledge, this study in 288 patients is the only one that retrospectively compares surgical (n=22) and nonsurgical (n=27) treatment in patients with recurrent cerebral embolism during infective endocarditis. Because less than half of the patients was operated on in this study, it appears plausible that also in the hospital of Dr Ruttmann not every patient with cerebral embolism during infective endocarditis was operated on during the study period 1985 to 2004. The clinical course of this nonsurgical patient group is not reported. It is of evident clinical importance to compare outcomes between patients who were operated purely on the indication of cerebral embolism (rather than cardiac failure) and those who were treated conservatively with antibiotic and supportive therapy. We wonder whether the authors could provide us with data about this nonsurgical group and possibly compare the outcome of these patients with the operated study group.

Thus, with the study of Ruttmann, it has become more clear that when a decision is made to operate, early surgery is safe. However, additional data of nonoperated patients could help to answer the essential question of whether the patient should be operated on or not.

Acknowledgments

Disclosures

None.

References

1. Ruttmann E, Willeit J, Ulmer H, Chevtchik O, Hofer D, Poewe W, Laufer G, Muller LC. Neurological outcome of septic cardioembolic stroke after infective endocarditis. Stroke. 2006; 37: 2094–2099.[Abstract/Free Full Text]

2. Bonow RO, Carabello BA, Kanu C, de Leon AC Jr, Faxon DP, Freed MD, Gaasch WH, Lytle BW, Nishimura RA, O’Gara PT, O’Rourke RA, Otto CM, Shah PM, Shanewise JS, Smith SC Jr, Jacobs AK, Adams CD, Anderson JL, Antman EM, Faxon DP, Fuster V, Halperin JL, Hiratzka LF, Hunt SA, Lytle BW, Nishimura R, Page RL, Riegel B. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. Circulation. 2006; 114: e84–231.[Free Full Text]

3. Horstkotte D, Piper C, Wiemer M, Arendt G, Steinmetz H, Bergemann R, Schulte HD, Schultheiss HP. [Emergency heart valve replacement after acute cerebral embolism during florid endocarditis]. Med Klin (Munich). 1998; 93: 284–293.[Medline] [Order article via Infotrieve]

This Article Extract Full Text (PDF) All Versions of this Article: 38/6/e31    most recent STROKEAHA.106.475848v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Schouten, J. Articles by van der Hoeven, H. G. Search for Related Content PubMed PubMed Citation Articles by Schouten, J. Articles by van der Hoeven, H. G.