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(Stroke. 2008;39:e137.)
© 2008 American Heart Association, Inc.

Letters to the Editor

Response to Letter by Nguyen and Raymond

Lucas Elijovich, MD S. Claiborne Johnston, MD, PhD

University of California San Francisco, Neurovascular Service, San Francisco, Calif

Response:

We appreciate Nguyen and Raymond’s comments on our work regarding intraprocedural rupture (IPR) of intracranial aneurysms and are glad they have given us the opportunity to underline the exploratory nature of our analysis. As we detailed previously, this work is limited by the retrospective nature of the data and post hoc analysis, and certainly not meant to guide clinical decision-making. The main purpose of CARAT was to evaluate long-term rehemorrhage rates in patients with treated ruptured aneurysms.¹ Having the data in hand, however, is it not more appropriate to publish tertiary analyses rather than force future investigators to trudge a new track in the deep snow, particularly in near virgin territory like intraprocedural rupture? We hope that the exploratory analysis of predictors of IPR will be of interest to investigators who may want to consider some of these variables, such as COPD, in prospective studies of aneurysm treatment and IPR, along with the more relevant variables that can only be assessed prospectively, as the authors have demonstrated.^2,3

Acknowledgments

Disclosures

None.

References

1. CARAT Investigators. Rates of delayed rebleeding from intracranial aneurysms are low after surgical and endovascular treatment. Stroke. 2006; 37: 1437–1442.[Abstract/Free Full Text]

2. Nguyen TN, Raymond J, Guilbert F, Roy D, Berube M, Mahmoud M, Weill A. Association of endovascular therapy of very small ruptured aneurysms with higher rates of procedure-related rupture. J Neurosurg. 2008; 108: 1088–1092.[CrossRef][Medline] [Order article via Infotrieve]

3. Sluzewski M, Bosch JA, van Rooij WJ, Nijssen PC, Wijnalda D. Rupture of intracranial aneurysms during treatment with Guglielmi detachable coils: incidence, outcome, and risk factors. J Neurosurg. 2001; 94: 238–240.[Medline] [Order article via Infotrieve]

This Article Extract Full Text (PDF) All Versions of this Article: 39/8/e137    most recent STROKEAHA.107.525568v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Elijovich, L. Articles by Johnston, S. C. Search for Related Content PubMed Articles by Elijovich, L. Articles by Johnston, S. C.