Published online before print April 17, 2008, doi: 10.1161/STROKEAHA.107.508507
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(Stroke. 2008;39:1661.)
© 2008 American Heart Association, Inc.
Editorials |
Symptomatic Intracranial Atherosclerotic Disease
What Is the Best Treatment Option?
From the Department of Neurology, Michigan State University, East Lansing, Mich.
Correspondence to Rishi Gupta, MD, Michigan State University, 138 Service Rd, A-217, East Lansing, MI 48824. E-mail Rishi.gupta{at}ht.msu.edu
Key Words: intracranial stenosis • stenting
See related article, pages 1766–1769.
Symptomatic intracranial atherosclerotic disease carries a significant risk for future ipsilateral ischemic events regardless of the use of warfarin or aspirin.1 Patients presenting with a lesion that is >70% appear to be most vulnerable with a 1-year risk of 23% for a subsequent ipsilateral event.2 Moreover, poor control of blood pressure and cholesterol appear to be associated with a higher risk of a subsequent stroke. At 1-year follow-up in the WASID study, 58% of patients were still found to have a LDL cholesterol of >100 mg/dL despite 91% of patients being on lipid-lowering therapy, and 50% of patients were found to have a systolic blood pressure >140 mm Hg.3 Recent guidelines suggest that patients at high risk for vascular disease may benefit from LDL cholesterol levels below 70 mg/dL,4 which was achieved in only 12% of patients in the WASID study at 1-year follow-up.3 This has highlighted the importance of vascular neurologists being more aggressive with risk factor modification as stroke victims are at a high risk for future vascular events.5
Endovascular therapy with balloon angioplasty for symptomatic intracranial atherosclerosis was first reported over 2 decades ago.6 Since this report, there have been several single institution reports along with multicenter registries showing the feasibility of performing angioplasty and/or stenting for symptomatic intracranial atherosclerotic lesions. No consensus has been reached as to the best endovascular modality (ie, balloon mounted stents, self-expanding stents or balloon angioplasty) to treat this disease. Due to the cerebrovascular tortuosity, there has been concern over the delivery of stiffer balloon mounted stents into the intracranial vasculature. With improving technology, the rates of successful delivery appear to be increasing with reports of success as high as 92% to 96%.7,8 The Wingspan stent system (Boston Scientific Corp) is a self-expanding stent that has been shown to also have a high success rate of delivery to the intracranial vasculature.9,10 There have been concerns over the high rate of restenosis (30%)11 associated with the Wingspan Stent, and some have argued that it may not be beneficial to place the stent after the angioplasty12 as there is not a substantial luminal gain (44% residual stenosis postangioplasty to 27% post–stent placement).9 Moreover, many of these studies do not address the medical compliance of patients in regards to blood pressure and cholesterol at follow-up. Patients with intracranial atherosclerosis appear to be in a high risk category, and thus medical control of risk factors may play a critical role in the success of preventing future vascular events or restenosis in patients treated with stents.
In this issue of Stroke, Mazighi et al13 report their experience with the use of balloon mounted stents or angioplasty alone for symptomatic intracranial lesions >70% that have failed maximal medical therapy. Importantly, only patients who presented with atheroembolic strokes were considered for stent placement and not patients with local perforator disease. In this cohort of patients, a wide array of coronary balloon mounted stents was used, but the failure rate to deliver a stent occurred in 8.7% of patients. This is similar to the rates of success described in other studies using balloon mounted stents.7,8 The authors show that periprocedural complication rate was 10.1%, but only an additional 2.9% of patients developed stroke or death at 24-month follow-up. This is similar to the findings of the SSYLVIA study where there was a 7.2% periprocedural rate of stroke, and at 1 year an additional 3.7% of patients were found to develop an ipsilateral stroke.14 In the Wingspan registry, 5 of 78 (6.4%) of patients had a periprocedural complication,9 whereas an additional 8 of 78 (10.3%) developed a symptomatic restenosis in follow-up.11 These reports suggest that patients treated with self-expanding stents may have a risk of delayed events, whereas treatment with balloon mounted stents may have a higher risk in the periprocedural period.
The authors of the current study also show that the rate of restenosis was 7.5% in patients treated with stents and 50% in patients treated with angioplasty alone with an overall rate of 15.9% for the cohort. One factor found to be associated with restenosis was a smaller vessel diameter. The importance of restenosis is still debatable, as only 2 patients (2.9%) developed symptoms referable to the restenosis. The causes of late lumen loss are not fully understood, but percent residual stenosis after stent deployment appears to be a significant predictor of restenosis in coronary vessels.15 In the current study as well as other reports, the poststent stenosis was under 10%.7,13 This may be an important parameter in prediction of restenosis during intracranial stent placement in the future, and stent type may play a role in this.
Given the high morbidity associated with symptomatic intracranial atherosclerosis, there has been interest in developing a randomized controlled study comparing stenting and angioplasty to medical therapy alone for symptomatic lesions 
70%.16 As these studies are designed, it will be important to recognize the differences in stent technology as well as the importance of medical compliance to achieve reduction of patient risk factor profiles as defined by current practice guidelines for these high risk patients.
Acknowledgments
Disclosures
None.
Footnotes
The opinions in this editorial are not necessarily those of the editors or of the American Heart Association.
References
- Chimowitz MI, Lynn MJ, Howlett-Smith H, Stern BJ, Hertzberg VS, Frankel MR, Levine SR, Chaturvedi S, Kasner SE, Benesch CG, Sila CA, Jovin TG, Romano JG; Warfarin-Aspirin Symptomatic Intracranial Disease Trial Investigators. Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis. N Engl J Med. 2005; 31: 1305–1316.
- Kasner SE, Chimowitz MI, Lynn MJ, Howlett-Smith H, Stern BJ, Hertzberg VS, Frankel MR, Levine SR, Chaturvedi S, Benesch CG, Sila CA, Jovin TG, Romano JG, Cloft HJ; Warfarin Aspirin Symptomatic Intracranial Disease Trial Investigators. Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis. Circulation. 2006; 113: 555–563.
[Abstract/Free Full Text] - Chaturvedi S, Turan TN, Lynn MJ, Kasner SE, Romano J, Cotsonis G, Frankel M, Chimowitz MI; for the WASID Study Group. Risk factor status and vascular events in patients with symptomatic intracranial stenosis. Neurology. 2007; 69: 2063–2068.
[Abstract/Free Full Text] - Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, Pasternak RC, Smith SC Jr, Stone NJ; National Heart, Lung, and Blood Institute: American College of Cardiology Foundation: American Heart Association. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation. 2004; 110: 227–239.
[Abstract/Free Full Text] - Elkind MSV, Curtis B. Lowering cholesterol in patients with stroke: raising the standard. Neurology. 2006; 66: 1140–1141.
[Free Full Text] - Sundt TM Jr, Smith HC, Campbell JK, Vliestra RE, Cucchiara RF, Stanson AW. Transluminal angioplasty for basilar artery stenosis. Mayo Clin Proc. 1980; 55: 673–680.[Medline] [Order article via Infotrieve]
- Freitas JMM, Zenteno M, Aburto-Murrieta Y, Koppe G, Abath C, Nunes JA, Raupp E, Hidalgo R, Pieruccetti MA, Lee A. Intracranial arterial stenting for symptomatic stenoses: a Latin American experience. Surg Neurol. 2007; 68: 378–386.[CrossRef][Medline] [Order article via Infotrieve]
- Jiang WJ, Xu XT, Du B, Dong KH, Jin M, Wang QH, Ma N. Comparison of elective stenting of severe vs moderate intracranial atherosclerotic stenosis. Neurology. 2007; 68: 420–426.
[Abstract/Free Full Text] - Fiorella D, Levy EI, Turk AS, Albuquerque FC, Niemann DB, Aagaard-Kienitz B, Hanel RA, Woo H, Rasmussen PA, Hopkins LN, Masaryk TJ, McDougall CG. US multicenter experience with the wingspan stent system for the treatment of intracranial atheromatous disease: periprocedural results. Stroke. 2007; 38: 881–887.
[Abstract/Free Full Text] - Bose A, Hartmann M, Henkes H, Liu HM, Teng MM, Szikora I, Berlis A, Reul J, Yu SC, Forsting M, Lui M, Lim W, Sit SP. A novel, self-expanding, nitinol stent in medically refractory intracranial atherosclerotic stenoses: the Wingspan study. Stroke. 2007; 38: 1531–1537.
[Abstract/Free Full Text] - Levy EI, Turk AS, Albuquerque FC, Niemann DB, Aagaard-Kienitz B, Pride L, Purdy P, Welch B, Woo H, Rasmussen PA, Hopkins LN, Masaryk TJ, McDougall CG, Fiorella DJ. Wingspan in-stent restenosis and thrombosis: incidence, clinical presentation and management. Neurosurgery. 2007; 61: 644–650.[Medline] [Order article via Infotrieve]
- Kallmes DF, Do HM. Wherefore Wingspan? AJNR Am J Neuroradiol. 2007; 28: 997–998.
[Free Full Text] - Mazighi M, Yadav J, Abou-Chebl A. Durability of endovascular therapy for symptomatic intracranial atherosclerosis. Stroke. 2008; 39: 1766–1769.
- SSYLVIA Study Investigators. Stenting of Symptomatic Atherosclerotic Lesions in the Vertebral or Intracranial Arteries (SSYLVIA): study results. Stroke. 2004; 35: 1388–1392.
[Abstract/Free Full Text] - Mercado N, Boersma E, Wijns W, Gersh BJ, Morillo CA, de Valk V, van Es GA, Grobbeee DE, Serruys PW. Clinical and quantitative coronary angiographic predictors of coronary restenosis: a comparative analysis from the balloon-to-stent era. J Am Coll Cardiol. 2001; 38: 645–652.
[Abstract/Free Full Text] - Derdeyn CP, Chimowitz MI. Angioplasty and stenting for atherosclerotic intracranial stenosis: rationale for a randomized clinical trial. Neuroimaging Clin N AM. 2007; 17: 355–333.[CrossRef][Medline] [Order article via Infotrieve]
Related Article:
- Durability of Endovascular Therapy for Symptomatic Intracranial Atherosclerosis
- Mikael Mazighi, Jay S. Yadav, and Alex Abou-Chebl
Stroke 2008 39: 1766-1769.[Abstract] [Full Text] [PDF]
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