on December 12, 2002
Published online before print December 12, 2002, doi: 10.1161/01.STR.0000046455.51363.E2
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Submitted on July 30, 2002
From the Departments of Neurology (J.E., M.R., S.M., H.P., T.P.), Electrical Engineering (W.W., H.E.), and Radiology (G.S.), Ruhr University Bochum, Bochum, Germany. * To whom correspondence should be addressed. E-mail: jeyding{at}web.de.
Background and Purpose—Established methods of ultrasonic perfusion imaging using a bolus application of echo contrast agent provide only qualitative data because of various physical phenomena. This study was intended to investigate whether a new ultrasound perfusion imaging method termed contrast burst depletion imaging (CODIM) may provide semiquantitative measures of parenchymal perfusion independent of examination depth and acoustic energy distribution. Methods—In a system with a constant concentration of contrast agent, analyzing the decrease in image intensity that occurs with microbubble-destructive imaging modes yields parameters that are considered to correlate with tissue perfusion. This method was first evaluated with a perfusion model that showed that the main resulting parameter "perfusion coefficient" (PC) is a monotonic nonlinear function of flow velocity. Seventeen human volunteers were then scanned according to this method with the use of 2 different contrast agents. Results were correlated with those from perfusion-weighted MRI examinations. Results—The PC did not show significant differences in gray matter areas (ranging from 1.466x10-2 s-1 to 1.641x10-2 s-1) of the brain despite different insonation depths (eg, ipsilateral and contralateral thalamus). In contrast, white matter exhibited significantly lower perfusion values in both imaging modes (PC: 0.604x10-2 s-1 to 0.745x10-2 s-1; P<0.05). Conclusions—CODIM is a promising new tool of imaging parenchymal (brain) perfusion in healthy persons. The method provides semiquantitative and depth-independent perfusion parameters and in this way overcomes the limitations of the perfusion methods using a bolus kinetic. Further investigations must be done to evaluate the potential of the method in patients with perfusion deficits.
Accepted on August 8, 2002
Contrast Burst Depletion Imaging (CODIM). A New Imaging Procedure and Analysis Method for Semiquantitative Ultrasonic Perfusion Imaging
Jens Eyding MD*;
Key words: cerebrovascular circulation • magnetic resonance imaging • perfusion • ultrasonography
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