Published Online
on March 20, 2003

A more recent version of this article appeared on April 1, 2003

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Submitted on October 16, 2002
Accepted on October 28, 2002

Thrombin-Activable Fibrinolysis Inhibitor Levels in the Acute Phase of Ischemic Stroke

Joan Montaner MD, PhD^*; Marc Ribó MD; Jasone Monasterio MD, PhD; Carlos A. Molina MD, PhD; and José Alvarez-Sabín MD, PhD

From the Cerebrovascular Unit (J. Montaner, M.R, C.A.M, J.A.S) and the Vascular Biology and Hemostasia Unit (J. Montaner, J. Monasterio), Vall d'Hebron Hospital, Barcelona, Spain.

^* To whom correspondence should be addressed. E-mail: 31862jmv{at}comb.es.

Background and Purpose--Thrombin-activable fibrinolysis inhibitor (TAFI) is a recently identified fibrinolysis inhibitor in plasma. The purpose of this work was to study TAFI levels in the acute phase of ischemic stroke and their relationship with stroke evolution.

Methods--In 30 consecutive ischemic stroke patients, TAFI plasma levels were measured by means of enzyme-linked immunosorbent assay (percentage of the pooled reference kit expressed as mean±SD) and compared with the values obtained in 30 healthy control subjects. All samples were drawn within the first 24 hours after symptom onset (mean, 4.6 hours) and before any treatment was started.

Results--TAFI plasma concentration was significantly higher (P<0.001) in stroke patients (158.4±53.2%) than in healthy control subjects (105.6±30.2%). The highest TAFI levels were found in cases of neurological deterioration (worsening, 198.1±63.0%; stability, 130.5±39.3%; improvement, 173.9±52.0%; P=0.057).

Conclusions--High levels of TAFI are found in the acute phase of ischemic stroke.

Key words: carboxypeptidase U • cerebral ischemia • stroke • TAFI • thrombolysis

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