Published Online
on March 20, 2003

A more recent version of this article appeared on April 1, 2003

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Submitted on October 24, 2002
Accepted on October 24, 2002

Feasibility of Radioactive Embolization of Intracranial Aneurysms Using ³²P-Implanted Coils

Jean Raymond MD^*; Philippe Leblanc PhD; Anick Lambert MSc; Stavros A. Georganos MD; François Guilbert MD; Christian Janicki PhD; and Sjoerd Roorda PhD

From the Department of Radiology (J.R., S.A.G., F.G.) and Research Centre (J.R., P.L., A.L.) of Centre Hospitalier de l'Université de Montréal; Department of Medical Physics (C. J.), McGill University Health Centre; and Physics Department (S.R.), Université de Montréal, Québec, Canada.

^* To whom correspondence should be addressed. E-mail: dr_jean_raymond{at}hotmail.com.

Background and Purpose--Beta radiation can prevent recanalization after embolization. Our goal was to assess the feasibility of endovascular treatment of intracranial aneurysms using coils of a predetermined activity of ³²P per centimeter.

Methods--We studied the total length of coils deployed into 357 intracranial aneurysms. Aneurysmal volumes were estimated using 3 mathematical models. We simulated that coils were implanted with 0.26 µCi/cm of ³²P, calculated resulting volumetric activities, and compared them with "effective" levels derived from experimental data and "safe" levels prescribed for the clinical use of ³²P in cystic craniopharyngiomas.

Results--Effective activities would have been reached in 92% to 98% of lesions had the coils been radioactive at the time of treatment.

Conclusion--Radioactive coil embolization of aneurysms is feasible in most patients.

Key words: aneurysm • endovascular therapy • radiation

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