on April 17, 2003
Published online before print April 17, 2003, doi: 10.1161/01.STR.0000069018.90456.C9
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on December 15, 2002
From the Department of Clinical Neurosciences, Western General Hospital, Edinburgh (R.A-S., R.J.S., C.P.W.); Institute of Neurological Sciences, Southern General Hospital, Glasgow (J.J.B., V.P.); Department of Neurosurgery, Aberdeen Royal Infirmary, Aberdeen (D.G.C.); Fauldhouse Health Centre, Fauldhouse (V.R.); and Department of Neurology, Ninewells Hospital and Medical School, Dundee (R.C.R.), Scotland. * To whom correspondence should be addressed. E-mail: Rustam.Al-Shahi{at}ed.ac.uk.
Background and Purpose--Intracranial vascular malformations (IVMs) are an important cause of intracranial hemorrhage, epilepsy, and long-term disability in adults. There are no published prospective, population-based studies dedicated to the detection of any type of IVM (cavernous malformations, venous malformations, and arteriovenous malformations [AVMs] of the brain or dura). Therefore, we established the Scottish Intracranial Vascular Malformation Study (SIVMS) to monitor detection and long-term prognosis of people with IVMs. Methods--We used multiple overlapping sources of case ascertainment to identify adults (aged Results--Of 418 notifications to SIVMS, 190 adults (45%) were included, 181 (95%) of whom were deemed to harbor a definite IVM after review of diagnostic brain imaging and/or reports of autopsy/surgical excision pathology. The crude detection rate (per 100 000 adults per year) was 2.27 (95% CI, 1.96 to 2.62) for all IVMs, 1.12 (95% CI, 0.90 to 1.37) for brain AVMs, 0.56 (95% CI, 0.41 to 0.75) for cavernous malformations, 0.43 (95% CI, 0.31 to 0.61) for venous malformations, and 0.16 (95% CI, 0.08 to 0.27) for dural AVMs. Conclusions--In addition to providing data on the public health importance and comparative epidemiology of IVMs, continuing recruitment and follow-up of this prospective, population-based cohort will provide estimates of IVM prognosis.
Accepted on December 18, 2002
Prospective, Population-Based Detection of Intracranial Vascular Malformations in Adults. The Scottish Intracranial Vascular Malformation Study (SIVMS)
Rustam Al-Shahi MA, MRCP(UK)*;
16 years) with a first-ever-in-a-lifetime diagnosis of any type of IVM made between January 1, 1999, and December 31, 2000, while resident in Scotland (mid-1999 adult population estimate 4 110 956).
Key words: central nervous system • cerebral arteriovenous malformations • incidence • prognosis • registries • vascular malformations
This article has been cited by other articles:
 |
|
 |
|
  C. Stapf and J.P. Mohr Unruptured Brain Arteriovenous Malformations Should Be Treated Conservatively: Yes Stroke, December 1, 2007; 38(12): 3308 - 3309. [Full Text] [PDF]
|
|
|
|
 |
|
 J van Beijnum, H B van der Worp, H M Schippers, O van Nieuwenhuizen, L J Kappelle, G J E Rinkel, J W B. van der Sprenkel, and C J M Klijn Familial occurrence of brain arteriovenous malformations: a systematic review J. Neurol. Neurosurg. Psychiatry, November 1, 2007; 78(11): 1213 - 1217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Khaw When Race/Ethnicity Matters More Than Size Stroke, September 1, 2007; 38(9): 2405 - 2406. [Full Text] [PDF]
|
|
|
|
 |
|
 B. E. Pollock and R. D. Brown Jr Use of the Modified Rankin Scale to assess outcome after arteriovenous malformation radiosurgery. Neurology, November 14, 2006; 67(9): 1630 - 1634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Choi, H. Mast, R. R. Sciacca, A. Hartmann, A. V. Khaw, J. P. Mohr, R. L. Sacco, and C. Stapf Clinical Outcome After First and Recurrent Hemorrhage in Patients With Untreated Brain Arteriovenous Malformation Stroke, May 1, 2006; 37(5): 1243 - 1247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Al-Shahi and C Warlow Arteriovenous malformations of the brain: ready to randomise? J. Neurol. Neurosurg. Psychiatry, October 1, 2005; 76(10): 1327 - 1329. [Full Text] [PDF]
|
|
|
|
|
|
J.P. Mohr Brain Arteriovenous Malformations: Children and Adults Stroke, October 1, 2005; 36(10): 2060 - 2061. [Full Text] [PDF]
|
|
|
|
|
|
A. X. Halim, S. C. Johnston, V. Singh, C. E. McCulloch, J. P. Bennett, A. S. Achrol, S. Sidney, and W. L. Young Longitudinal Risk of Intracranial Hemorrhage in Patients With Arteriovenous Malformation of the Brain Within a Defined Population Stroke, July 1, 2004; 35(7): 1697 - 1702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.V. Khaw, J.P. Mohr, R.R. Sciacca, H.C. Schumacher, A. Hartmann, J. Pile-Spellman, H. Mast, and C. Stapf Association of Infratentorial Brain Arteriovenous Malformations With Hemorrhage at Initial Presentation Stroke, March 1, 2004; 35(3): 660 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Stapf, A.V. Khaw, R.R. Sciacca, C. Hofmeister, H.C. Schumacher, J. Pile-Spellman, H. Mast, J.P. Mohr, and A. Hartmann Effect of Age on Clinical and Morphological Characteristics in Patients With Brain Arteriovenous Malformation Stroke, November 1, 2003; 34(11): 2664 - 2669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Al-Shahi, J. J. Bhattacharya, D. G. Currie, V. Papanastassiou, V. Ritchie, R. C. Roberts, R. J. Sellar, and C. P. Warlow Scottish Intracranial Vascular Malformation Study (SIVMS): Evaluation of Methods, ICD-10 Coding, and Potential Sources of Bias in a Prospective, Population-Based Cohort Stroke, May 1, 2003; 34(5): 1156 - 1162. [Abstract] [Full Text] [PDF]
|
|