on June 26, 2003
Published online before print June 26, 2003, doi: 10.1161/01.STR.0000080535.61188.A6
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Submitted on March 11, 2003
From the Departments of Neurology, Heinrich-Heine University Düsseldorf, Düsseldorf (R.J.S., M.H., U.J., M.S.), and Karl-Rupprecht Universität Heidelberg, Heidelberg (P.A.R., C.S.), Germany. * To whom correspondence should be addressed. E-mail: seitz{at}neurologie.uni-duesseldorf.de.
Background and Purpose--We sought to investigate the feasibility of the combined use of low-dose recombinant tissue plasminogen activator (rtPA) and tirofiban, a glycoprotein IIb/IIIa (GPIIb/IIIa) receptor antagonist, for systemic thrombolysis in acute stroke. Methods--Consecutive patients who were treated with systemic application of low-dose rtPA and body weight-adjusted tirofiban (rtPA+T group; n=37) were evaluated retrospectively during 1999-2001. Patients in the rtPA+T group were compared with a group of patients treated with a dose of 0.9 mg/kg body weight in a different center (rtPA group; n=119). The 41 patients with infarctions of the middle cerebral artery territory who were not eligible for thrombolytic treatment because of medical contraindications or arrival in the hospital >3 hours after stroke onset served as controls. For matched comparisons, the National Institutes of Health Stroke Scale on admission and the Rankin Scale on discharge 5 days after stroke were used. Results--The patients treated with rtPA+T or rtPA improved (P<0.05) compared with the controls at discharge; patients in the rtPA+T and rtPA groups reached a Rankin Scale score of 0 to 2 in 63% and 55%, respectively, while only 16% of the controls achieved this score. Death rates (8% in rtPA+T group and 5% in rtPA group) were similar among the 2 treatment groups. They included 1 fatal hemorrhage in the rtPA+T group and 4 fatal hemorrhages in the rtPA group. Five percent of the untreated patients developed symptomatic, nonfatal cerebral hemorrhage. Conclusions--Systemic combined thrombolysis with rtPA+T seems to be a feasible treatment in acute stroke.
Accepted on March 20, 2003
Thrombolysis With Recombinant Tissue Plasminogen Activator and Tirofiban in Stroke. Preliminary Observations
Rüdiger J. Seitz MD*;
Key words: platelet glycoprotein GPIIb-IIIa complex • platelets • stroke • thrombolysis
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