Published Online
on October 16, 2003

A more recent version of this article appeared on November 1, 2003

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Submitted on July 2, 2003
Accepted on July 8, 2003

Role of Monitoring in Management of Acute Ischemic Stroke Patients

Anna Cavallini MD^*; Giuseppe Micieli MD; Simona Marcheselli MD; and Silvana Quaglini PhD

From the Cerebrovascular Department/Stroke Unit, C. Mondino Foundation (A.C, G.M., S.M.), and Department of Computer Science and Systems, University of Pavia (S.Q.), Pavia, Italy.

^* To whom correspondence should be addressed. E-mail: anna.cavallini{at}mondino.it.

Background and Purpose--Although several studies have demonstrated the effectiveness of specialist Stroke Unit (SU) care of stroke patients, there is still disagreement over how these units are best organized. We sought to clarify the role of continuous monitoring of physiological parameters in acute ischemic stroke.

Methods--We conducted a prospective study of 268 first-ever ischemic stroke patients admitted to our Cerebrovascular Department and allocated, according to the availability of beds, to the SU or Cerebrovascular Unit (CU). Statistical analysis compared mortality and outcome at discharge, medical and neurological complications, and length of hospitalization in the 2 care settings.

Results--Two hundred sixty-eight patients were enrolled. A good outcome at discharge, observed in 114 SU patients (85%) and 78 CU patients (58%) (odds ratio, 2.63; 95% CI, 1.4 to 4.8; P<0.02), was found, on multivariate analysis, to be significantly related to type of care (SU versus CU). A significantly greater proportion of SU patients showed adverse changes in monitored parameters, which required acute medical treatment (SU: 64%; CU: 19%; P<0.0001). The mean duration of these complications was significantly shorter in the SU patients (SU: 1.0 day; CU: 2.4 days; P<0.02), and the outcome in patients experiencing complications covered by the monitoring protocol was significantly better in the SU (66%) than in the CU (35%) group (P<0.0001).

Conclusions--Admission of acute stroke patients to a monitoring SU may positively influence their outcome at discharge. Confirmation of our findings in larger trials will indicate the need for a revision of the minimum requirements of SUs, with the addition of monitoring as a new requirement.

Key words: monitoring • stroke, ischemic • stroke management • stroke units

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